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Case 51 - Nothing Can Be Done

from Part 10 - Management Misadventures

Published online by Cambridge University Press:  03 November 2020

Keith Josephs
Affiliation:
Mayo Clinic Alzheimer’s Disease Research Center
Federico Rodriguez-Porcel
Affiliation:
Medical University of South Carolina
Rhonna Shatz
Affiliation:
University of Cincinnati
Daniel Weintraub
Affiliation:
University of Pennsylvania
Alberto Espay
Affiliation:
University of Cincinnati
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Summary

This 70-year-old right-handed man presented with a 4-year history of worsening forgetfulness. Since his retirement as a lawyer he noticed increasing difficulties recalling recent conversations and finding words. His family reported he was unintentionally repeating questions and stories. In addition, he was not as active as before and spent more time watching TV. One year earlier, he discussed his concerns with his primary care physician whose evaluation revealed a Mini-Mental State Examination score (MMSE) of 24/30, unremarkable screening labs, and a brain MRI which showed mild generalized atrophy. He was told he had mild cognitive impairment (MCI) which is considered a predementia stage. He was on donepezil 10 mg daily and memantine 10 mg twice daily, with no meaningful changes in his cognition or function.

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