Plasmacytoid Dendritic Cells

doi:10.1017/9781009397797.038

Chapter 38 - Plasmacytoid Dendritic Cells

From Normal Maturation to Neoplastic Proliferations

from Section 6 - Neoplastic Plasmacytoid Dendritic Cell Proliferation

Published online by Cambridge University Press: 20 May 2026

Wei Wang

Edited by

Wei Wang and

Sa A. Wang

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Wei Wang: Affiliation:
The University of Texas MD Anderson Cancer Center
Sa A. Wang: Affiliation:
The University of Texas MD Anderson Cancer Center

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Summary

This chapter describes the normal maturation pattern of plasmacytoid dendritic cells (pDCs), as well as the dynamic antigenic changes during pDC differentiation. Common markers used to define the pDC lineage are included, with their advantages and limitations discussed. Key immunophenotypic features associated with neoplastic pDC proliferations (blastic plasmacytoid dendritic cell neoplasm, myeloid neoplasms with plasmacytoid dendritic cell differentiation, and mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm) are covered. Minimal residual disease evaluation of pDC neoplasms is also discussed. Finally, the differential diagnosis associated with pDC proliferations is addressed.

Keywords

plasmacytoid dendritic cells pDCs maturation immunophenotype blastic plasmacytoid dendritic cell neoplasm BPDCN myeloid neoplasms with plasmacytoid dendritic cell differentiation pDC-AML mature plasmacytoid dendritic cell proliferation MPDCP differential diagnosis

Information

Type: Chapter
Information: Flow Cytometry in Hematolymphoid Neoplasms
A Comprehensive and Practical Guide to Diagnosis
, pp. 333 - 344
DOI: https://doi.org/10.1017/9781009397797.038 [Opens in a new window]
Publisher: Cambridge University Press
Print publication year: 2026

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