Modern experimental techniques in exploring and understanding our brain and mind have shown that brain processes are intimately connected with the generation of states of consciousness. Against this background, near-death experiences (NDEs), including out-of-body experiences (OBEs), can be validated as phenomena generated in altered states of consciousness of the mind. In the history of research on NDE phenomena, paranormal or metaphysical explanations often included personal views and belief in a “life after life” or purely speculative quantum physical approaches to consciousness. The assurance that extraordinary experiences such as NDEs have their origin in physiology-dependent psychological processes of the brain of the experiencer, and not in an unknown, paranormal, or mystical entity, points to therapies usable by medical and psychological professionals to help all those who may suffer from confusion, disorientation, or fear as aftereffects of their experiences.