Cognitive Impairment in Major Depressive Disorder: Clinical Relevance, Biological Substrates, and Treatment Opportunities

Danielle S. Cha

doi:10.1017/CBO9781139860567

Major depressive disorder (MDD) is the leading cause of disability globally in both developed and developing nations. The staggering economic costs attributable to MDD are largely a consequence of impairment in role function. Evidence indicates that disturbance in the domain of cognitive function in individuals with MDD is the principal determinant of health outcome. This is the first book to comprehensively explore the domain of cognition in MDD. The literature describing cognitive dysfunction is reviewed with particular focus on clinical determinants, pathophysiology and causative factors. The patient subpopulations most susceptible are defined. A summary of contemporary assessment tools for research and clinical purposes is provided. Multimodality treatments and prevention strategies are described. This book is an invaluable resource for psychiatrists, neuropsychologists and other members of the mental health team, as well as for policy makers, vocation rehabilitation experts, disability providers and other stakeholders interested in improving health outcomes in MDD.

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Contents

Cognitive Impairment in Major Depressive DisorderClinical Relevance, Biological Substrates, and Treatment Opportunities
pp i-ii
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Cognitive Impairment in Major Depressive Disorder - Title page
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Copyright page
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Contents
pp v-vi
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Figures
pp vii-viii
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Tables
pp ix-x
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Contributors
pp xi-xiv
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Preface
pp xv-xvi
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Abbreviations
pp xvii-xxiv
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Part I - Clinical relevance of cognitive dysfunction in major depressive disorder
pp 1-144
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1 - Does cognitive dysfunction predate the onset of incident depression?
pp 1-14
- By Julia Buthmann, Danielle S. Cha, Roger S. McIntyre
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2 - Understanding the importance of cognitive dysfunction and cognitive change in major depressive disorder
pp 15-29
- By Paul Maruff, Judith Jaeger
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3 - Cognition in MDD: implications for primary care
pp 30-46
- By Larry Culpepper
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4 - Neurocognition in pediatric depression
pp 47-59
- By Dwight F. Newton, Melanie R. Naiberg, Benjamin I. Goldstein
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5 - Neuroanatomy of cognition in major depressive disorder
pp 60-68
- By Guy M. Goodwin
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6 - Hot and cold cognition in major depressive disorder
pp 69-80
- By Oliver J. Robinson, Jonathan P. Roiser, Barbara J. Sahakian
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7 - Social cognition and emotional processing in major depressive disorder
pp 81-91
- By Philippe Fossati, Sophie Hinfray
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8 - The role of social cognition in major depressive disorder
pp 92-109
- By Bernhard T. Baune, Michael Weightman
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9 - Are cognitive deficits in major depressive disorder progressive?
pp 110-124
- By Marie Laure Cléry-Melin, Philip Gorwood
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10 - Implications of cognitive impairments on functional outcomes in major depressive disorder
pp 125-144
- By Tracy L. Greer, Cassandra R. Hatt
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Part II - Underlying biological substrates associated with cognitive dysfunction in major depressive disorder
pp 145-228
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11 - Cognition and biomarkers in major depressive disorder: endophenotype or epiphenomenon?
pp 145-159
- By Shane J. McInerney, Philip Gorwood, Sidney H. Kennedy
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12 - Inflammation and cognition in major depressive disorder
pp 160-178
- By Bernhard T. Baune
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13 - HPA axis and cognitive dysfunction in mood disorders
pp 179-193
- By Rebecca Strawbridge, Allan H. Young
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14 - White matter neurobiology and cognitive dysfunction in major depressive disorder
pp 194-208
- By Geoffrey Chern-Yee Tan, Kang Sim
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15 - Insulin resistance and implications for hippocampal volume/function and the default mode network
pp 209-228
- By Heather A. Kenna, Tonita E. Wroolie, Danielle R. Balzafiore, Natalie L. Rasgon
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Part III - Evaluating cognitive dysfunction in major depressive disorder
pp 229-256
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16 - Measuring the mind: detecting cognitive deficits and measuring cognitive change in patients with depression
pp 229-241
- By John E. Harrison
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17 - Subjective measures of cognitive dysfunction in major depressive disorder
pp 242-250
- By Raymond W. Lam
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Appendix 17.1 - British Columbia Cognitive Complaints Inventory (BC-CCI). Also available at http://goo.gl/zdhVyg (accessed September 25, 2015)
pp 251-250
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Cognitive Impairment in Major Depressive Disorder

Clinical Relevance, Biological Substrates, and Treatment Opportunities

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