Gene Therapy in the Treatment of Cancer: Progress and Prospects

doi:10.1017/CBO9780511663352

The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the last few decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks forward to future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the work of the contributors themselves. Topical and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

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Contents

Frontmatter
pp i-vi
- By Brian E. Huber
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Contents
pp vii-viii
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Contributors
pp ix-x
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Preface
pp xi-xii
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1 - Introduction: gene therapy approaches to cancer
pp 1-8
- By Brian E. Huber
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2 - Principles of transformation-directed cancer therapy
pp 9-40
- By Ian Magrath, Kishor Bhatia
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3 - Vectors for cancer gene therapy
pp 41-77
- By Prem Seth
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4 - Genetically engineering drug sensitivity and drug resistance for the treatment of cancer
pp 78-96
- By Brian E. Huber
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5 - Oncogene inactivation and replacement strategies for cancer
pp 97-107
- By Jack A. Roth
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6 - Genetically modified tumor cells as tumor vaccines
pp 108-136
- By John C. Krauss, Suyu Shu, Alfred E. Chang
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7 - Genetically modified lymphocytes and hematopoietic stem cells as therapeutic vehicles
pp 137-148
- By Patrick J. Geraghty, James J. Mulé
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8 - Pharmacologic effects of oligonucleotides and some clinical applications
pp 149-165
- By Leonard M. Neckers, Kanak Iyer
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9 - Current status of gene marking and gene therapy in oncology clinical trials
pp 166-199
- By Cynthia A. Richards
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10 - Safety testing for gene therapy products
pp 200-208
- By J. Patrick Condreay
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Index
pp 209-216
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Gene Therapy in the Treatment of Cancer

Progress and Prospects

Book description

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

Contributors
pp ix-x

Preface
pp xi-xii

1 - Introduction: gene therapy approaches to cancer
pp 1-8

2 - Principles of transformation-directed cancer therapy
pp 9-40

3 - Vectors for cancer gene therapy
pp 41-77

4 - Genetically engineering drug sensitivity and drug resistance for the treatment of cancer
pp 78-96

5 - Oncogene inactivation and replacement strategies for cancer
pp 97-107

6 - Genetically modified tumor cells as tumor vaccines
pp 108-136

7 - Genetically modified lymphocytes and hematopoietic stem cells as therapeutic vehicles
pp 137-148

8 - Pharmacologic effects of oligonucleotides and some clinical applications
pp 149-165

9 - Current status of gene marking and gene therapy in oncology clinical trials
pp 166-199

10 - Safety testing for gene therapy products
pp 200-208

Index
pp 209-216

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Gene Therapy in the Treatment of Cancer

Progress and Prospects

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Contents

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