Immunological Aspects of the Vascular Endothelium

doi:10.1017/CBO9780511752629

Originally published in 1995, this volume looks at the functioning of the vascular endothelium, and the diseases and tissue injury that arise as a result of inflammation and immunological responses. The vascular endothelium is a metabolically highly active layer of cells lining all blood vessel walls. Through its interactions with leucocytes and other mediators, it is central to the development of inflammatory foci and to lymphocyte trafficking around the body. Tissue injury may arise here as a result of abnormal inflammatory or immune responses. The potential for such injury to contribute to autoimmune disease is discussed in this book, particularly in relation to autoimmune vascular disease of the renal, rheumatological and neurological systems, as well as in organ transplantation.

"This is a stimulating monograph...recommended for readers interested in the endothelium and its rapid ascendance to the status of an immunologic organ." John A. Robinson, Doody's Health Sciences Book Review Journal

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of contributors
pp ix-x
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Preface
pp xi-xii
- By Caroline Savage, Jeremy Pearson
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1 - New concepts of mechanisms in autoimmunity
pp 1-19
- By Daniel M. Altmann
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2 - Regulation of endothelial cell function by cytokines
pp 20-42
- By Jeremy D. Pearson, Michael J. May
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3 - Interactions between granulocytes and endothelium
pp 43-63
- By Sussan Nourshargh
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4 - The regulation of lymphocyte migration by vascular endothelium and its role in the immune response
pp 64-95
- By Ann Ager
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5 - Role of the vascular endothelium in immunologically mediated neurological diseases
pp 96-123
- By Virginia Calder, John Greenwood
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6 - The role of the endothelium in systemic lupus erythematosus and Sjögren's syndrome
pp 124-152
- By Huw L. C. Beynon, P. Athanassiou, Kevin A. Davies
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7 - The role of the endothelium in rheumatoid arthritis and scleroderma
pp 153-172
- By Robert J. Moots, Paul Emery
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8 - The role of the endothelium in systemic vasculitis
pp 173-199
- By Abeed A. Pall, Caroline O. S. Savage
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9 - Endothelial involvement in childhood Kawasaki disease
pp 200-212
- By Michael J. Dillon
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10 - The role of the endothelium in thrombotic thrombocytopaenic purpura and haemolytic uraemic syndrome
pp 213-232
- By Carla Zoja, Giuseppe Remuzzi
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11 - The immunological role of the endothelium in organ transplantation
pp 233-252
- By John R. Bradley
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Index
pp 253-261
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Immunological Aspects of the Vascular Endothelium

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of contributors
pp ix-x

Preface
pp xi-xii

1 - New concepts of mechanisms in autoimmunity
pp 1-19

2 - Regulation of endothelial cell function by cytokines
pp 20-42

3 - Interactions between granulocytes and endothelium
pp 43-63

4 - The regulation of lymphocyte migration by vascular endothelium and its role in the immune response
pp 64-95

5 - Role of the vascular endothelium in immunologically mediated neurological diseases
pp 96-123

6 - The role of the endothelium in systemic lupus erythematosus and Sjögren's syndrome
pp 124-152

7 - The role of the endothelium in rheumatoid arthritis and scleroderma
pp 153-172

8 - The role of the endothelium in systemic vasculitis
pp 173-199

9 - Endothelial involvement in childhood Kawasaki disease
pp 200-212

10 - The role of the endothelium in thrombotic thrombocytopaenic purpura and haemolytic uraemic syndrome
pp 213-232

11 - The immunological role of the endothelium in organ transplantation
pp 233-252

Index
pp 253-261

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Immunological Aspects of the Vascular Endothelium

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