Contents

pp vii-viii

Contributors

pp ix-xii

Preface

pp xiii-xiv

Part I - Types of Imaging Reporter Genes

pp 1-2

1 - Fluorescent Reporter Proteins

pp 3-40

2 - Revealing Biomolecular Mechanisms Through In Vivo Bioluminescence Imaging

pp 41-69

3 - Reporter Gene Imaging with PET/SPECT

pp 70-87

4 - Noninvasive Imaging of Gene Expression with Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy

pp 88-110

Part II - Enhancing Reporter Gene Imaging Techniques

pp 111-112

5 - Multimodality Imaging of Reporter Genes

pp 113-126

6 - Cell-Specific Imaging of Reporter Gene Expression Using a Two-Step Transcriptional Amplification Strategy

pp 127-148

Part III - Imaging Instrumentations

pp 149-150

7 - Physics, Instrumentation, and Methods for Imaging Reporter Gene Expression in Living Subjects

pp 151-192

Part IV - Current Applications of Imaging Reporter Genes

pp 193-194

8 - Reporter Gene Imaging of Cell Signal Transduction

pp 195-226

9 - Gene Therapy and Imaging of Transgene Expression in Living Subjects

pp 227-238

10 - Imaging Regulation of Endogenous Gene Expression in Living Subjects

pp 239-257

11 - Imaging Cell Trafficking and Immune Cell Activation Using PET Reporter Genes

pp 258-274

12 - Imaging of Reporter Genes and Stem Cells

pp 275-296

13 - Clinical Applications of Reporter Gene Technology

pp 297-314

Index

pp 315-321