Susceptibility to Infectious Diseases: The Importance of Host Genetics

doi:10.1017/CBO9780511546235

In the last fifteen years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book summarises advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and the book is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology.

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Contents

Frontmatter
pp i-v
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Contents
pp vi-vii
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Contributors
pp viii-xv
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1 - Introduction
pp 1-6
- By Richard Bellamy, Kintampo Health Research Centre, Ghana
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2 - Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections
pp 7-44
- By Alexandre Alcaïs, Human Genetics of Infectious Diseases, Necker Medical School, University René Descartes, Laurent Abel, Human Genetics of Infectious Diseases, Necker Medical School, University René Descartes
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3 - The diverse genetic basis of immunodeficiencies
pp 45-76
- By Mauno Vihinen, Institute of Medical Technology, Finland and Tampere University Hospital
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4 - Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases
pp 77-116
- By Leland J. Yee, Imperial College, Faculty of Medicine at St. Mary's Hospital, London, United Kingdom; London School of Hygiene and Tropical Medicine, London, United Kingdom, Mark R. Thursz, Imperial College, Faculty of Medicine at St. Mary's Hospital, London, United Kingdom
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5 - The cystic fibrosis transmembrane conductance regulator
pp 117-138
- By Alan W. Cuthbert, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
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6 - The influence of inherited traits on malaria infection
pp 139-184
- By David J. Roberts, Nuffield Department of Clinical Laboratory Sciences and National Blood Service-Oxford Centre, John Radcliffe Hospital, United Kingdom, Tyler Harris, Nuffield Department of Clinical Laboratory Sciences and National Blood Service-Oxford Centre, John Radcliffe Hospital, United Kingdom, Thomas Williams, Wellcome Trust-KEMRI Centre for Geographic Medicine, Kenya; Department of Paediatrics, Faculty of Medicine, Imperial College of Science Technology and Medicine, Exhibition Road United Kingdom
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7 - Polymorphic chemokine receptor and ligand genes in HIV infection
pp 185-220
- By Jianming (James) Tang, Division of Geographic Medicine, Department of Medicine, School of Medicine, Richard A. Kaslow, Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham
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8 - NRAMP 1 and resistance to intracellular pathogens
pp 221-258
- By Philippe Gros, Department of Biochemistry; Centre for the Study of Host Resistance; McGill Cancer Centre, Erwin Schurr, Centre for the Study of Host Resistance; Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec Canada
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9 - The interleukin-12/interferon-γ loop is required for protective immunity to experimental and natural infections by Mycobacterium
pp 259-278
- By Marion Bonnet, Laboratory of Human Genetics of Infectious Diseases, Université René Descartes, Necker Medical School, Paris, Claire Soudais, Laboratory of Human Genetics of Infectious Diseases, Université René Descartes, Necker Medical School, Paris, Jean-laurent Casanova, Laboratory of Human Genetics of Infectious Diseases, Université René Descartes, Necker Medical School, Paris
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10 - Mannose-binding lectin deficiency and susceptibility to infectious disease
pp 279-308
- By Dominic L. Jack, Institute of Child Health, University College London, United Kingdom; Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom, Nigel J. Klein, Institute of Child Health, University College London, United Kingdom, Malcolm W. Turner, Institute of Child Health, University College London, United Kingdom
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11 - Blood group phenotypes and infectious diseases
pp 309-336
- By C. Caroline Blackwell, Discipline of Immunology and Microbiology and Hunter Immunology Unit, University of Newcastle, Newcastle, Australia; Institute for Scientific Evaluation of Naturopathy, University of Cologne, Cologne, Germany, Donald M. Weir, Department of Medical Microbiology, The Medical School, University of Edinburgh, Abdulhamid M. Alkout, Department of Medical Microbiology, The Medical School, University of Edinburgh, Omar R. Elahmer, Department of Medical Microbiology, The Medical School, University of Edinburgh, Doris A. C. MacKenzie, Department of Medical Microbiology, The Medical School, University of Edinburgh, Valerie S. James, Department of Medical Microbiology, The Medical School, University of Edinburgh, J. Matthias Braun, Department of Medical Microbiology, The Medical School, University of Edinburgh; Institute for Scientific Evaluation of Naturopathy, University of Cologne, Cologne, Germany, Osama M. Almadani, Department of Medical Microbiology, The Medical School University of Edinburgh; Forensic Medicine Unit, Edinburgh, Scotland, United Kingdom, Anthony Busuttil, Forensic Medicine Unit, The Medical School University of Edinburgh, Edinburgh, Scotland, United Kingdom
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12 - Genetics of human susceptibility to infection and hepatic disease caused by schistosomes
pp 337-360
- By Alain J. Dessein, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Sandrine Marquet, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Carole Eboumbou Moukoko, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Hèlia Dessein, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Laurent Argiro, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Sandrine Henri, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Dominique Hillaire, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Christophe Chevillard, Immunologie et Génétique des Maladies Parasitaires, Institut National de la Santé et de la Recherche Médicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Marseille, France, Nasureldin El Wali, Institute of Nuclear Medicine and Molecular Biology, University of Gezira, Wad Medani, Sudan, Mubarak Magzoub, Institute of Nuclear Medicine and Molecular Biology, University of Gezira, Wad Medani, Sudan, Laurent Abel, Génétique Humaine des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Necker, Paris, Virmondes Rodrigues, Jr, Faculty of Medicine do Triangulo Mineiro, Ubéraba, Brazil, Aluizio Prata, Faculty of Medicine do Triangulo Mineiro, Ubéraba, Brazil, Gachuhi Kimani, Kenya Medical Research Institute, Biomedical Sciences Research Centre, Nairobi, Kenya
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13 - Genetic susceptibility to prion diseases
pp 361-392
- By Matthew Bishop, Departments of Pathology and Clinical Neurosciences, CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, J. W. Ironside, Departments of Pathology and Clinical Neurosciences, CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
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Index
pp 393-398
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Plate section
pp 399-406
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Susceptibility to Infectious Diseases

The Importance of Host Genetics

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Contents

Frontmatter
pp i-v

Contents
pp vi-vii

Contributors
pp viii-xv

1 - Introduction
pp 1-6

2 - Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections
pp 7-44

3 - The diverse genetic basis of immunodeficiencies
pp 45-76

4 - Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases
pp 77-116

5 - The cystic fibrosis transmembrane conductance regulator
pp 117-138

6 - The influence of inherited traits on malaria infection
pp 139-184

7 - Polymorphic chemokine receptor and ligand genes in HIV infection
pp 185-220

8 - NRAMP 1 and resistance to intracellular pathogens
pp 221-258

9 - The interleukin-12/interferon-γ loop is required for protective immunity to experimental and natural infections by Mycobacterium
pp 259-278

10 - Mannose-binding lectin deficiency and susceptibility to infectious disease
pp 279-308

11 - Blood group phenotypes and infectious diseases
pp 309-336

12 - Genetics of human susceptibility to infection and hepatic disease caused by schistosomes
pp 337-360

13 - Genetic susceptibility to prion diseases
pp 361-392

Index
pp 393-398

Plate section
pp 399-406

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Susceptibility to Infectious Diseases

The Importance of Host Genetics

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