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Attention profiles in autistic children with and without comorbid hyperactivity and attention problems

Published online by Cambridge University Press:  24 June 2014

Judith Sinzig,
Nicole Bruning,
Dagmar Morsch and
Gerd Lehmkuhl
Judith Sinzig*
Affiliation:
Department of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany
Nicole Bruning
Affiliation:
Department of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany
Dagmar Morsch
Affiliation:
Department of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany
Gerd Lehmkuhl
Affiliation:
Department of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany
*
Dr Judith Sinzig, Department of Child and Adolescent Psychiatry, University of Cologne, Robert-Koch-Str. 10, D-50931 Cologne, Germany. Tel: +49 221 478 4370; Fax: +49 221 478 6104; E-mail: judith.sinzig@uk-koeln.de
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Abstract

Objective:

Psychopathological, neuropsychological and genetic findings indicate an association between ASD Spectrum Disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). The goal of this study was to compare the neuropsychological profiles of attention functions in children with ADHD and with ASD and without comorbid ADHD. The hypothesis was that either ADHD and autistic children with comorbid ADHD symptoms were more impaired in inhibition and sustained attention performance and that all individuals with ASD show more deficits in divided attention.

Method:

Children aged 6 to 18 years old with ADHD (n =30) or ASD with (n =21) and without comorbid ADHD (n =20) and 30 healthy children were included consecutively. Psychopathology was evaluated using the KIDDIE-SADS and symptom checklists for ADHD and ASD according to DSM-IV. Assessed neuropsychological functioning included inhibition, sustained as well as divided attention and alertness tasks.

Results:

Age and IQ-corrected z-scores were used. Statistically significant group effects were found for the variables sustained attention median (F =3.2, = .02), hits (F =3.3, p =.02) and false alarms (F =3.9, p =.01), divided attention hits (F =3.3, p =.02), errors (F =3.1, p =.03) and false alarms (F =3.3, p =.03) and alertness false alarms (F =2.9, p =.04). Pearson Correlations revealed associations between ADHD symptoms and sustained attention in the ADHD group and between ADHD symptoms and inhibition in the ASD+ group.

Conclusion:

Our hypothesis was partly confirmed as ADHD children showed more deficits in sustained attention and ASD children in divided attention tasks. However there was no evidence that children with ASD and comorbid ADHD symptoms have a specific profile in comparison to pure ASD children.

Keywords

ADHDattentionautismneuropsychology

Information

Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 4 , August 2008, pp. 207 - 215
Copyright
Copyright © 2008 Blackwell Munksgaard

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References

Frazier, TW, Biederman, J, Bellorde, CAet al. Should the diagnosis of attention-deficit/hyperactivity disorder be considered in children with pervasive developmental disorder? J Atten Disord 2001;4:203–211. CrossRefGoogle Scholar
Goldstein, S, Schwebach, AJ. The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: results of a retrospective chart review. J Autism Dev Disord 2004;34:329–339. CrossRefGoogle ScholarPubMed
Gadow, K, DeVincent, CJ, Pomeroy, J. ADHD symptom subtypes in children with pervasive developmental disorder. J Autism Dev Disord 2006;36:271–283. CrossRefGoogle ScholarPubMed
Leyfer, OT, Folstein, SE, Bacalman, Set al. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J Autism Dev Disord 2006;36:849–861. CrossRefGoogle ScholarPubMed
Clark, T, Feehan, C, Tinline, C, Vostanis, P. Autistic symptoms in children with attention deficit-hyperactivity disorder. Eur Child Adolesc Psychiatry 1999;8:50–55. CrossRefGoogle ScholarPubMed
Yoshida, Y, Uchiyama, T. The clinical necessity for assessing attention deficit/hyperactivity disorder (AD/HD) symptoms in children with high-functioning pervasive developmental disorder (PDD). Eur Child Adolesc Psychiatry 2004;13:307–314. CrossRefGoogle ScholarPubMed
American Academy of Child & Adolescent Psychiatry. Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders. Washington, DC: AACAP publications department, 1999. Google Scholar
Fisher, SE, Francks, C, McCracken, JTet al. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 2002;70:1183–1196. CrossRefGoogle ScholarPubMed
Smalley, SL, Loo, SK, Yang, MH, Cantor, RM. Toward localizing genes underlying cerebral asymmetry and mental health. Am J Med Genet B: Neuropsychiatr Genet 2005;135:79–84. CrossRefGoogle Scholar
Bakker, SC, Van der Meulen, EM, Buitelaar, JKet al. A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q. Am J Hum Genet 2003;72:1251–1260. CrossRefGoogle ScholarPubMed
Ogdie, MN, Macphie, IL, Minassian, SLet al. A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11. Am J Hum Genet 2003;72:1268–1279. Google Scholar
Eliez, S, Reiss, A. MRI neuroimaging of childhood psychiatric disorders: a selective review. J Child Psychol Psychiatry 2000;41:679–694. Google ScholarPubMed
Faraone, SV, Biedermann, J. Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 1998;44:951–958. CrossRefGoogle ScholarPubMed
Rinehart, NJ, Bradschaw, JI, Moss, SA, Bereton, AV, Tonge, BJ. A deficit in shifting attention present in high functioning autism but not in Asperger’s disorder. Autism 2001;5:67–80. CrossRefGoogle ScholarPubMed
Ozonoff, S, Cook, I, Coon, Het al. Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network. J Autism Dev Disord 2004;34:139–150. CrossRefGoogle Scholar
Johnson, KA, Robertson, IH, Kelly, SPet al. Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia 2007;45:2234–2245. CrossRefGoogle ScholarPubMed
Nigg, JT. Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: the state of the field and salient challenges for the coming decade. Biol Psychiatry 2005;57:1424–1435. CrossRefGoogle ScholarPubMed
Hill, EL. Evaluating the theory of executive dysfunction in autism. Dev Res 2004;24:189–233. Google Scholar
Geurts, HM, Verté, S, Oosterlaan, J, Roeyers, H, Sergeant, JA. How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J Child Psychol Psychiatry 2004;45:836–854. Google ScholarPubMed
Goldberg, MC, Mostofsky, SH, Cutting, LEet al. Subtle executive impairment in children with autism and children with ADHD. J Autism Dev Disord 2005;35:279–293. CrossRefGoogle ScholarPubMed
Happé, F, Booth, R, Charlton, R, Hughes, C. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain Cogn 2006;61:25–39. CrossRefGoogle ScholarPubMed
Ozonoff, S, Jensen, J. Brief report: specific executive function profiles in three neurodevelopmental disorders. J Autism Dev Disord 1999;29:171–177. CrossRefGoogle ScholarPubMed
Nyden, A, Gillberg, C, Hjelmquist, E, Heiman, M. Executive function/attention deficits in boys with Asperger syndrome, attention disorder and reading/writing disorder. Autism 1999;3:213–228. CrossRefGoogle Scholar
Zimmermann, P, Fimm, B. Testbatterie zur Aufmerksamkeitsprüfung (TAP), Version 1.0. Freiburg: Psytest, 1993. Google Scholar
Földényi, M, Tagwerker-Neuenschwander, F, Giovanoli, A, Schallberger, U, Steinhausen, HC. Die Aufmerksamkeitsleistungen von 6-10-jährigen Kindern in der TAP. Zeitschrift für Neuropsychologie 1999;10:87–102. CrossRefGoogle Scholar
Van Zomeren, AH, Brouwer, WH. Clinical neuropsychology of attention. New York: Oxford Press, 1994. Google Scholar
Shanahan, MA, Pennington, BF, Yerys, BEet al. Processing speed deficits in attention deficit/hyperactivity disorder and reading disability. J Abnorm Child Psychol 2006;34:585–602. CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, text revision (DSM-IV-TR), 4th edn. Washington, DC: American Psychiatric Association, 2000. Google Scholar
Greenhill, LL. Childhood attention-deficit/hyperactivity disorder: pharmacological treatments. In: Nathan, PE, Gorman, J, eds. A guide to treatments that work. New York: Oxford University Press, 1998: 42–64. Google Scholar
Boelte, S, Poustka, F. Die Faktorenstruktur des Autismus Diagnostischen Interviews-Revision (ADI-R). Eine Untersuchung zur dimensionalen versus kategorialen Klassifikation autistischer Störungen. Zeitschrift für Kinder Jugendpsychiatrie 2001;29:221–229. CrossRefGoogle Scholar
Ruehl, D, Boelte, S, Feineis-Matthews, S. Poustka. Diagnostische Beobachtungsskala für Autistische Störungen. Bern: Huber, 2004. Google Scholar
Doepfner, M, Lehmkuhl, G. Diagnostik-System für Psychische Störungen im Kindes- und Jugendalter nach ICD-10 und DSM-IV (DISYPS-KJ), 2nd edn. Bern: Huber, 2002. Google Scholar
Herpertz, SC, Dietrich, TM, Wenning, Bet al. Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study. Biol Psychiatry 2001;50:292–298. CrossRefGoogle ScholarPubMed
Konrad, K, Gunther, T, Hanisch, C, Herpertz-Dahlmann, B. Differential effects of methylphenidate on attentional functions in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2004;43:191–198. CrossRefGoogle ScholarPubMed
DuPaul, GJ, Ervin, RA, Hook, CL, McGoey, KE. Peer tutoring for children with attention deficit hyperactivity disorder: effects on classroom behavior and academic performance. J Appl Behav Anal 1998;31:579–592. CrossRefGoogle ScholarPubMed
Kaufman, J, Birmaher, B, Brent, DA, Ryan, ND, Rao, U. K-SADS-PL. J Am Acad Child Adolesc Psychiatry 2000;39:1208. CrossRefGoogle ScholarPubMed
Turner, M. Towards an executive dysfunction account of repetitive behaviour in autism. In: Russel, J, ed. Autism as an executive disorder. New York: Oxford University Press, 1997: 57–100. Google Scholar
Bruehl, B, Doepfner, M, Lehmkuhl, G. Der Fremdbeurteilungsbogen für hyperkinetischeStörungen (FBB-HKS) – Prävalenz hyperkinetischer Störungen im Elternurteil und psychometrische Kriterien. Kindheit und Entwicklung 2000;9:116–126. CrossRefGoogle Scholar
Hanisch, C, Konrad, K, Gunther, T, Herpertz-Dahlmann, B. Age-dependent neuropsychological deficits and effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a comparison of pre- and grade-school children. J Neural Transm 2004;111:865–881. CrossRefGoogle ScholarPubMed
Garretson, HB, Fein, D, Waterhouse, L. Sustained attention in children with autism. J Autism Dev Disord 1990;20:101–114. CrossRefGoogle ScholarPubMed
Noterdaeme, M, Amorosa, H, Mildenberger, K, Sitter, S, Minow, F. Evaluation of attention problems in children with autism and children with a specific language disorder. Eur Child Adolesc Psychiatry 2001;10:58–66. CrossRefGoogle ScholarPubMed
Clark, C, Prior, M, Kinsella, GJ. Do executive functions differentiate between adolescents with ADHD and oppositional defiant/conduct disorder? A neuropsychological study using the 6 Elements Test and Hyaling Sentence Completion Test. J Abnorm Child Psychol 2000;28:403–414. CrossRefGoogle Scholar
Oosterlaan, J, Logan, GD, Sergeant, JA. Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task. J Child Psychol Psychiatry 1998;39:411–425. Google ScholarPubMed
Schaughency, EA, Lahey, BB, Hynd, GW, Stone, PA, Piacentini, JC, Frick, PJ. Neuropsychological test performance and the attention deficit disorders: clinical utility of the Luria-Nebraska Neuropsychological Battery—Children’s Revision. J Consult Clin Psychol 1989;57:112–116. CrossRefGoogle ScholarPubMed
Nyden, A, Hjelmquist, E, Gillberg, C. Autism spectrum and attention-deficit disorders in girls. Some neuropsychological aspects. Eur Child Adolesc Psychiatry 2000;9:180–185. Google ScholarPubMed
Holtmann, M, Boelte, S, Poustka, F. Attention deficit hyperactivity disorder symptoms in pervasive developmental disorders: association with autistic behavior domains and coexisting psychopathology. Psychopathology 2007;40:172–177. CrossRefGoogle ScholarPubMed
Holtmann, M, Boelte, S, Poustka, F. Autism spectrum disorders: sex differences in autistic behaviour domains and coexisting psychopathology. Dev Med Child Neurol 2007;49:361–366. CrossRefGoogle ScholarPubMed