Hostname: page-component-7b7567c8c-fvjsw Total loading time: 0 Render date: 2026-11-15T06:06:38.775Z Has data issue: false hasContentIssue false
  • English
  • Français

Cholesterol and psyche

Published online by Cambridge University Press:  18 September 2015

N. Duits and
W. Van Tilburg
N. Duits*
Affiliation:
Voorheen werkzaam in het Academisch Medisch Centrum, afdeling kinder- en jeugdpsychiatrie, Amsterdam.
W. Van Tilburg
Affiliation:
vakgroep psychiatrie van de Vrije Universiteit. PCA/Valerius Kliniek, Amsterdam.
*
Purmerenderweg 214, 1461 DN Zuidoostbeemster
Get accessRights & Permissions [Opens in a new window]

Summary

This paper reviews the relationship between cholesterol and psychological functioning. Possibly a relationship exists between the lowering of cholesterol, low serum cholesterol concentration and mood and/or impulse control disorders. This might be associated with a disregulated cerebral serotonin metabolism. These hypotheses are based on (meta-analyses of) epidemiologic research investigating the lowering of cholesterol. One of the findings was an increased mortality due to suicide, homicide and accidents. Much is still unknown about the matters mentioned above. However, recommendations for research and clinical psychiatric practice are formulated.

Keywords

Cholesterolserotoninmortalitysuïcidedepressiondepressive symptomsCholesterolserotoninemortaliteitsuicidedepressiedepressieve symptomen

Information

Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 4 , December 1995, pp. 122 - 126
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Literatuur

1.Duits, N, Bos, FM. Psychiatrische stoornissen bij simvastatine gebruik. Ned Tijdschr Geneeskd 1993; 137: 1312–5.Google Scholar
2.Leichleitner, M, Hopplicher, F, Konwalinka, G, Patsch, JR, Braunsteiner, H. Depressive symptoms in hypercholesterolaemic patients treated with pravastatin (Letter). Lancet 1992; 340: 910.CrossRefGoogle Scholar
3.LaRosa, JC. Cholesterol and cardiovascular disease: how strong is the evidence? Clin. Cardiol 1992; 15: Suppl. III: 2–7.CrossRefGoogle ScholarPubMed
4.Verschuren, WMM, Al, M, Blokstra, A, Boerma, GJM, Kromhout, D. Veranderingen in het serumcholesterolgehalte bij de Nederlandse bevolking in de periode 1974-1986. Ned Tijdschr Geneeskd 1992; 136,579-83.Google Scholar
5.Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) The Lancet 1994;344: 1383–9.Google Scholar
6.Muldoon, MF, Manuck, SB, Matthews, KA. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. Br med J 1990; 301: 309–14.CrossRefGoogle ScholarPubMed
7.Hawton, K, Cowen, P, Owens, D, Bond, A, Elliot, M. Low serum cholesterol and suicide. Br J Psychiat 1993; 162: 818–25.CrossRefGoogle Scholar
8.Davey Smith, G, Pekkanen, J. Should there be a moratorium on the use of cholesterol-lowering drugs? Br med J 1992; 304: 431–4.CrossRefGoogle ScholarPubMed
9.Jacobs, D, Blackburn, H, Higgins, Met al.Report of the conference on low blood cholesterol: mortality associations. Circulation 1992; 86: 1046–60.CrossRefGoogle ScholarPubMed
10.Davey Smith, G, Song, F, Sheldon, FA. Cholesterol lowering and mortality: the importance of considering initial level of risk. Br med J 1993; 306: 1367–73.CrossRefGoogle Scholar
11.Davey Smith, G, Shipley, MJ, Marmot, MG, Rose, G. Plasma cholesterol concentration and mortality. The Whitehall study. JAMA 1992; 267: 70–6.CrossRefGoogle Scholar
12.Kronmal, RA, Cain, KC, Zhan, Ye, Omenn, GS. Total serum cholesterol levels and mortality risk as a functioning of age. Arch intern Med 1993; 153: 1065–73.CrossRefGoogle ScholarPubMed
13.Lindberg, G, Rastam, L, Gullberg, B, Eklund, GA. Low serum cholesterol concentration and short term mortality from injuries in men and women. Br med J 1992; 305: 277–9.CrossRefGoogle ScholarPubMed
14.Weidner, G, Connor, SL, Hollis, JF. Improvements in hostility and depression in relation to dietary change and cholesterol lowering. Ann int Med 1992; 117: 820–3.CrossRefGoogle ScholarPubMed
15.Brett, AS. Psychological effects of the diagnosis and treatment of hypercholesterolemia: lessons from case studies. Am J Med 1991; 91: 642–7.CrossRefGoogle ScholarPubMed
16.Virkkunen, M. Serum cholesterol in antisocial personality. Neu-ropsychobiology 1979; 5: 27–30.Google ScholarPubMed
17.Virkkunen, M. Serum cholesterol in homicidal offenders. A low cholesterol level is connected with a habitually violent tendency under the influence of alcohol. Neuropsychobiology 1983; 10: 659.Google ScholarPubMed
18.Virkkunen, M, Pentinnen, H. Serum cholesterol in aggressive conduct disorder: a preliminary study. Biol Psychiat 1984; 19: 435–9.Google ScholarPubMed
19.Morgan, RE, Palinkas, LA, Barret-Connor, EL, Wingard, DL. Plasma cholesterol and depressive symptoms in older men. Lancet 1993; 341: 75–9.CrossRefGoogle ScholarPubMed
20.Dealberto, MJ, Ducimetierre, P, Mainard, F, Alperovitch, A. Serum lipids and depression (Letter). Lancet 1993; 341: 435.Google Scholar
21.Brown, SL, Salive, ME, Harris, TB, Simonsick, EM, Guralnik, JM, Kohout, FJ. Low cholesterol concentrations and severe depressive symptoms in elderly people. Br med J 1994; 308: 1328–32.CrossRefGoogle ScholarPubMed
22.Strandberg, TE, Valvanne, J, Tilvis, RS. Serum lipids and depression (Letter). Lancet 1993; 341: 433–4.CrossRefGoogle Scholar
23.Modai, I, Valevski, A, Dror, S, Weizman, A. Serum cholesterol levels and suicidal tendencies in psychiatric inpatients. J clin Psychiat 1994; 55: 6,252-4.Google ScholarPubMed
24.Sullivan, PF, Joyce, PR, Bulik, CM, Mulder, RT, Oakley-Browne, M. Total cholesterol and suicidality in depression. Biol Psychiat 1994; 36,472-7.Google ScholarPubMed
25.Fowkes, FGR, Leng, GC, Donnan, PT, Dery, IJ, Riemersma, RA, Housley, E. Serum cholesterol, triglycerides and aggression in the general population. Lancet 1992; 340: 995–8.CrossRefGoogle ScholarPubMed
26.Davey Smith, G, Shipley, MJ, Marmot, MG, Patel, C. Lowering cholesterol concentrations and mortality. Br med J 1990; 301:552.Google Scholar
27.Maes, M, Delanghe, J, Meitzer, HY, Scharpé, S, D'Hondt, PD, Cosyns, P. Lower degree of esterification of serum cholesterol in depression: relevance for depression and suicide research. Acta psychiat scand 1994; 90: 252–8.CrossRefGoogle ScholarPubMed
28.Engelberg, H. Low serum cholesterol and suicide. Lancet 1992; 340: 995–8.Google Scholar
29.Mason, RP, Herbette, LG, Silverman, DI. Can altering serum cholesterol affect neurologic function? J mol Cell Cardiol 1991: 23: 1339-42.CrossRefGoogle ScholarPubMed
30.Boyer, WF, Feighner, JP. The serotonin hypothesis: necessary but not sufficient. In: Feighner, JP, Boyer, WF, eds. Selective Serotonin Reuptake Inhibitors. Perspectives in Psychiatry. Vol, I. Chicester: John Wiley, 1991: 71–80.Google Scholar
31.Ringo, DL, Lindley, SE, Faull, KF, Faust, MA. Cholesterol and serotonin: seeking a possible link between blood cholesterol and CSF 5-HIAA. Biol Psychiat 1994; 35: 957–9.CrossRefGoogle ScholarPubMed
32.Kaplan, JR, Manuck, SB, Shively, C. The effects of fat and cholesterol on social behavior in monkeys. Psychosom Med 1991; 53: 634–42.CrossRefGoogle ScholarPubMed
33.Muldoon, MF, Kaplan, JR, Manuck, SB, Mann, JJ. Effects of a low-fat diet on brain serotonergic responsivity in cynomolgus monkeys. Biol Psychiat 1992; 31: 739–42.CrossRefGoogle ScholarPubMed
34.Coccaro, EF, Siever, LJ, Klar, HMet al.Serotonergic studies in patiens with affective and personality disorders. Arch gen Psychiat 1989; 46:587-99.CrossRefGoogle Scholar
35.Bond, AJ. Fowkes et al's ‘serum cholesterol, triglycerides, and aggression in the general population’. Br J Psychiat 1993; 163: 666–8.CrossRefGoogle ScholarPubMed
36.Goldstein, MG, Niaura, R. Psychological factors affecting physical condition. Cardiovascular disease literature review. Psychoso-matics 1992; 33: 134–45.CrossRefGoogle ScholarPubMed
37.Niaura, R, Stoney, CM, Herbert, PN. Lipids in psychological research: The last decade. Biol Psychol 1992; 43: 1–43.CrossRefGoogle Scholar
38.Hayward, C, Barr Taylor, C, Roth, WT. Lipid levels in patients with panic disorder or agorafobia. Am J Psychiat 1989; 146: 917–9.Google ScholarPubMed
39.Baywa, WK, Asnis, GM, Sanderson, WC, Irfan, A, van Praag, HM. High cholesterol levels in patients with panic disorder. Am J Psychiat 1992; 149: 376–8.Google Scholar
40.Smith, DF. Type A personalities tend to have low platelet monoamine oxidase activity. Acta psychiat scand 1994; 89: 88–91.CrossRefGoogle ScholarPubMed