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Genetics of bipolar disorders

Published online by Cambridge University Press:  18 September 2015

D. Souery,
I. Massat and
J. Mendlewicz
D. Souery*
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Brussels, Belgium
I. Massat
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Brussels, Belgium
J. Mendlewicz
Affiliation:
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Brussels, Belgium
*
Department of Psychiatry, University Clinics of Brussels Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium Fax 32-2-5554515E-mail, dsouery@arcadis.be
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Abstract

Advances towards the understanding of the etiological mechanisms involved in mood disorders provide interesting yet diverse hypotheses and promising models. In this context, molecular genetics has now been widely incorporated into genetic epidemiological research in psychiatry. Affective disorders and, in particular, bipolar affective disorder (BPAD) have been examined in many molecular genetic studies which have covered a large part of the genome, specific hypotheses such as mutations have also been studied. Most recent studies indicate that several chromosomal regions may be involved in the aetiology of BPAD. Other studies have reported the presence of anticipation in BPAD. This phenomenon describes the increase in clinical severity and decrease in age of onset observed in successive generations. This mode of transmission correlates with the presence of specific mutations (Trinucleotide Repeat Sequences) and may represent a genetic factor involved in the transmission of the disorder. In parallel to these new developments in molecular genetics, the classical genetic epidemiology, represented by twin, adoption and family studies, provided additional evidence in favour of the genetic hypothesis in mood disorders. Moreover, these methods have been improved through models to test the gene-environment interactions. While significant advances have been made in this major field of research, it appears that integrative models, taking into account the interactions between biological (genetic) factors and social (psychosocial environment) variables offer the most reliable way to approach the complex mechanisms involved in the etiology and outcome of mood disorders.

Keywords

affective disordersmolecular geneticscomplex traits

Information

Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000, pp. 65 - 68
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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