Hostname: page-component-6898cfcb55-cbk24 Total loading time: 0 Render date: 2026-11-11T11:49:47.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Manic episode, thyroid gland function and lithium

Published online by Cambridge University Press:  18 September 2015

K. Foeken and
B.J.M. van de Wetering
K. Foeken*
Affiliation:
destijds verbonden aan de afdeling Psychiatrie van het Academisch Ziekenhuis Rotterdam-Dijkzigt (hoofd: Prof. dr. W.J. Schudel) thans Sophia Kinderziekenhuis
B.J.M. van de Wetering
Affiliation:
verbonden aan de afdeling Psychiatrie van het AZR-Dijkzigt
*
Afdeling Kinderpychiatrie, Academisch Ziekenhuis Rotterdam - Dijkzigt/Sophia Kinderziekenhuis Gordelweg 160 3038 CE Rotterdam
Get accessRights & Permissions [Opens in a new window]

Summary

This paper addresses the issue of (recurrent) mania in relation to an increased T4-value, whether or not influenced by lithium. Lithium has an anti-TSH-effect on the thyroid gland by inhibiting the intracellular enzyme adenylate cyclase. This might cause hypothyroidism. Moreover, lithium is also known to have a direct stabilizing effect on (behavioral manifestations) of dopamine receptor supersensitivity.

The hypothesis regarding the relation between thyroid function and affective disturbances is that the altered thyroid function may cause a change in the availability of the central dopamine receptors. Dopamine is known to be able to cause a manic state. TSH and TRH are also involved in this mechanism. It is, therefore, very likely that an increased thyroid function, whether or not caused by discontinuation of lithium-therapy, could induce a (recurrent) mania.

Keywords

affective disorderthyroid glandlithiumstemmingsstoornisschildklierlithium

Information

Type
Research Article
Information
Acta Neuropsychiatrica , Volume 4 , Issue 3 , September 1992, pp. 52 - 56
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Literatuur

1.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington DC: American Psychiatric Press, 1987.Google Scholar
2.Milner, PM.Theories of reinforcement. In: Iversen, GG, Iversen, SD, Snyder, SH (red). Handbook of Psychopharmacology. New York & London: Plenum Press, 1977: 181–200.CrossRefGoogle Scholar
3.Depue, RA, Iacono, WG.Neurobehavioral aspects of affective disorder. Ann Rev Psychol 1989; 40:457–92.CrossRefGoogle Scholar
4.Goodwin, FK, Murphy, DL, Brodie, HKH, Bunney, WE. JrL-DOPA, catecholamines and behavior. A clinical and biochemical study in depressed patients. Biol Psychiat 1970; 2: 341–66.Google ScholarPubMed
5.Murphy, DL, Brodie, HKH, Goodwin, FK, Bunney, WE. JrRegular induction of hypomania by L-DOPA in bipolar manic depressive patients. Nature 1971; 229:135–6.CrossRefGoogle ScholarPubMed
6.Jacobs, D, Silverstone, T.Dextroamphetamine induced arousal in human subjects as a model for mania. Psychol Med 1986; 16:323–9.CrossRefGoogle Scholar
7.Silverstone, T.Dopamine, mood and manic depressive psychosis. In: Garattini, S (red). Depressive Disorders. Stuttgart: FK Schattanner Verlag, 1978:114–430.Google Scholar
8.Goodwin, FK, Jamison, KR.Manic depressive illness. In: red. New York, Oxford Univ Press: Biochemical and Pharmacological studies, 1990:419–21.Google Scholar
9.Chiodo, LA, Antelman, SM.Tricyclic antidepressants induce sub-sensitivity of presynaptic dopamine autoreceptors. Eur J Pharmacol 1980; 64:203–4.CrossRefGoogle Scholar
10.Flentge, F.Mogelijke werkingsmechanismen van lithium. In: Nolen, WA (red). Lithium, de stand van zaken. Den Haag: Symposiumverslag, 1987:30–6.Google Scholar
11.Bunney, WE, Garland-Bunney, BL.Mechanisms of action of lithium in affective illness: Basic and clinical implications. In: Meitzer, HY, red. Psychopharmacology, the 3rd Generation of Progress. New York: Raven Press, 1987:553–65.Google Scholar
12.Salata, R, Klein, I.Informative review. J Lab clin Med 1987; 110:130–6.Google Scholar
13.Bakker, K.Lithium en de schildklier. In: Nolen, WA (red). Lithium, de stand van zaken. Den Haag: Symposiumverslag, 1987:62–8.Google Scholar
14.Emerson, CH, Dyson, WL, Utiger, RD.Serum thyrotropin and thyroxine concentrations in patients receiving lithium carbonate. J clin Endocrinol Metab 1973; 36:338–46.CrossRefGoogle Scholar
15.Maarbjerg, K, Vestergaard, P, Schou, M.Changes in serum thyroxine and serum thyroid stimulating hormone during prolonged lithium treatment. Acta psychiat scand 1987; 75:217–21.CrossRefGoogle ScholarPubMed
16.Yassa, R, Saunders, A, Nastase, C, Camille, Y.Lithium induced thyroid disorders. A prevalence study. J clin Psychiat 1988; 49:146.Google ScholarPubMed
17.Denicoff, KD, Joffe, RT, Lakshmanan, MC, Robbins, J, Rubinow, DR.Neuropsychiatric manifestations of altered thyroid state. Am J Psychiat 1990; 147:94–9.Google ScholarPubMed
18.Gold, MS, Pottash, AC, Mueller, EA III, Extens, IRL.Grades of thyroid failure in 100 depressed and anergic psychiatric in-patients. Am J Psychiat 1982; 138:253–5.Google Scholar
19.Lishman, WA.Organic Psychiatry. Chpt II: Endocrine diseases and metabolic disorders. 2 ed. Oxford: Blackwell Sci Publ, 1987.Google Scholar
20.Dackis, CA, Goggans, FC, Bloodworth, R, et al.The prevalence of hypothyreoidism in psychiatric populations. Fair Oaks Hosp Psychiat Lett 1986; 4:49–54.Google Scholar
21.Mason, JW, Kennedy, JL, Kosten, TR, Giller, EL.Serum thyroxine levels in schizophrenic and affective disorder diagnostic subgroups. J nerv ment Dis 1989; 177:351–8.CrossRefGoogle ScholarPubMed
22.Müller, B, Bönig, J.Changes in the pituitary thyroid axis accompanying major affective disorders. Acta psychiat scand 1988; 77:143–50.CrossRefGoogle ScholarPubMed
23.Crocker, AD, Overstreet, DH.Modification of the behavioral effects of haloperidol and of dopamine receptor regulation by altered thyroid status. Psychopharmacol 1984; 82:102–6.CrossRefGoogle ScholarPubMed
24.Kirkegaard, C, Bjørum, N, Faber, CJ, Lauridsen, UB, Nerup, J.Studies on the influence of biogenic amines and psychoactive drugs on the prognostic value of the TRH stimulation test in endogenous depression. Psychoneuroendocrin 1977; 2:131–6.CrossRefGoogle ScholarPubMed
25.Beasley, CM Jr, Magnusson, M, Garver, DL.TSH respons to TRH and haloperidol respons latency in psychoses. Biol Psychiat 1988; 24:423–31.CrossRefGoogle Scholar
26.Rens, VI, Gold, P, Post, R.Lithium induced thyrotoxicosis. Am J Psychiat 1979; 136:724–5.Google Scholar
27.Prasad, C.Neurobiology of cyclo(His-Pro). Ann NY Acad Sci 1989; 553:232–51.CrossRefGoogle ScholarPubMed