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Neuropathological studies of bipolar disorder

Published online by Cambridge University Press:  18 September 2015

P.J. Harrison
P.J. Harrison*
Affiliation:
University Department of Psychiatry, Oxford, United Kingdom
*
Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford 0X3 7JX, United Kingdom Fax 00-44-1865 251076, E-mail paul.harrison@psych.ox.ac.uk
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Abstract

The few available neuropathological studies of bipolar disorder are reviewed and placed in the context of structural imaging findings. Candidate pathological processes include cy-toarchitectural abnormalities, particularly in the anterior cingulate cortex and affecting glia, and disruption of white matter connections. The possible neuropathological relationship of bipolar disorder with major depression and with schizophrenia is discussed.

Keywords

astrocytesaffective disordermood disorderneuropathologypost mortem

Information

Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000, pp. 96 - 98
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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References

1.Elkis, H. Friedman, L. Wise, A. Meitzer, HY. Meta-analyses of ventricular enlargement and cortical sulcal prominence in mood disorders: Comparisons with controls or patients with schizophrenia. Arch Gen Psychiatry 1995:52:735–746.CrossRefGoogle ScholarPubMed
2.Hoge, EA. Friedman, L, Schulz, SC. Meta-analysis of brain size in bipolar disorder. Schizophr Res 1999:37:177–746.CrossRefGoogle ScholarPubMed
3.Altshuler, LL. Bartzokis, G. Grieder, T. Curran, J. Mintz, J. Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia. An MRI study demonstrating neuroanatomy specificity. Arch Gen Psychiatry 1998:55:663–664.Google Scholar
4.Strakowski, SM. DeBello, MP. Sax, K.W. Zimmerman, R. Shear, PK. Hawkins, JM. Larson, ER. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 1999:56:254–260.CrossRefGoogle ScholarPubMed
2.Drevets, WC. Price, JL. Simpson, JR. Todd, RD. Reich, T. Vannier, M. Raichle, ME. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997:386:824–827.CrossRefGoogle ScholarPubMed
3.Videbech, P. MRI findings in patients with affective disorder:a metaanalysis. Acta Psychiatr Scand 1997:96:157–168.CrossRefGoogle ScholarPubMed
4.Beckmann, H. Jakob, H. Prenatal disturbances of nerve cell migration in the entorhinal region: a common vulnerability factor in functional psychoses? J Neural Transm 1991:84:155–164.CrossRefGoogle ScholarPubMed
8.Bernstein, H-G. Krell, D. Baumann, B. Danos, P. Falkai, P. Diekmann, S. Henning, H. Bogerts, B. Morphometric studies of the entorhinal cortex in neuropsychiatric patients and controls: clusters of heterotopically displaced lamina II neurons are not indicative of schizophrenia.Schizophr Res 1998:33:125–132.CrossRefGoogle Scholar
9.Harrison, PJ. The neuropathology of schizophrenia - A critical review of the data and their interpretation. Brain 1999:122:593–624.CrossRefGoogle ScholarPubMed
10.Bencs, FM. Kwok, EW. Vincent, SL. Todtenkopf, MS. Reduction of nonpvramidal cells in section CA2 of schizophrenics and manic depressives. Biol Psychiatry 1998:44:88–97.Google Scholar
11.Öngur, D. Drevets, WC. Price, JL. Glial reductions in the subgenual prefrontal cortex in mood didsorders. Proc Natl Acad Sci USA 1998:95:13290–13295.CrossRefGoogle Scholar
12.Cotter, D. Mackay, D. Beasley, C. Kerwin, R. Everall, I. Reduced glial density and neuronal volume in major depressive disorder and schizophrenia in the anterior cingulate cortex. Schizophr Res 2000:41:106.CrossRefGoogle Scholar
13.Torrey, EF. Webster, M. Knable, M. Johnston, N. Yolken, RH. The Stanley Foundation brain collection and neuropathology consortium. Schizophr Res 2000: in pressCrossRefGoogle ScholarPubMed
14.Orlovskaya, DD. Vosrtikov, VM. Rachmanova, VI. Uranova, NA. Decreased numerical density of oligodendroglial cells in postmortem prefrontal cortex in schizophrenia, bipolar affective disorder and major depression. Schizophr Res 2000:41:105–106.CrossRefGoogle Scholar
15.Webster, MJ, Johnston-Wilson, N. Nagata, K, Yolken, RH. Alterations in the expression of phosphorylated glial fibrillary acidic proteins in the frontal cortex of individuals with schizophrenia, bipolar disorder and depression. Schizophr Res 2000:41:106.CrossRefGoogle Scholar
16.Vawter, MP. Hyde, TM. Kleinman, JE. Freed, WJ. Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia. Mol Psychiatry 1999;4:467–475.CrossRefGoogle ScholarPubMed
17.Eastwood, SL. Harrison, PJ. Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs. Mol Psychiatry 2000: in press.CrossRefGoogle ScholarPubMed
18.Harrison, PJ. Eastwood, SL. Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. Lancet 1998:352:1669–1673.CrossRefGoogle ScholarPubMed