Colonial chroniclers marveled at the quality and variety of textiles produced at the Postclassic center of Cholula. As a principal market center, textiles were produced for tribute and exchange, and other woven goods were manufactured for local consumption. This paper examines ethnohistorical and archaeological evidence to interpret the technology, materials, scale, and social relations of textile production. Original spindle-whorl data from the UA-1 domestic compound is contrasted with other whorls from Postclassic Cholula and from other sites in central Mexico. Results of this analysis indicate the complexity of pre-Columbian textile production and the significance of spinning and weaving in economic and social reconstructions of the past.