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Genetically Modified Animals, Welfare and UK Legislation

Published online by Cambridge University Press:  11 January 2023

R Hubrecht
R Hubrecht*
Affiliation:
UFAW, 8 Hamilton Close, South Mimms, Potters Bar, Herts EN6 3QD, UK
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Extract

Introduction

The first experiments in genetic engineering took place in the late sixties and early seventies, but animal transgenics (the insertion of DNA into the genome of an animal) really came of age with the production of mice whose genetic sequences contained a gene for human growth hormone (Palmiter et al 1982). Since then there has been a dramatic increase in the quantity of research into genetic modification, using various techniques. This has been largely driven by the potential medical and financial benefits of being able to modify animal and plant genomes (Carver et al 1993; Smith 1994; Stewart et al 1993).

Information

Type
Invited Essay
Information
Animal Welfare , Volume 4 , Issue 3 , August 1995, pp. 163 - 170
Copyright
© 1995 Universities Federation for Animal Welfare

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References

Advisory Committee on Genetic Modification 1989 Guidelines on work with transgenic animals, Note 9. In: Compendium of Guidance Notes from the Health and Safety Commission’s Advisory Committee on Genetic Modification. Health and Safety Executive. 12ppGoogle Scholar
Berlanga, J, Infante, J, Capo, V, de la Fuente, J and Castro, F O 1993 Characterization of transgenic mice lineages. 1. Overexpression of hGH causes the formation of liver intranuclear pseudoinclusion bodies and renal and hepatic injury. Acta Biotechnologica 13: 361–371Google Scholar
Bird, A R, Croom, W J, Black, B L, Fan Υ, K and Daniel, L R 1994 Somatotropin transgenic mice have reduced jejunal active glucose transport rates. Journal of Nutrition 124: 2189–2196CrossRefGoogle ScholarPubMed
Broom, D M 1993 Assessing the welfare of modified or treated animals. Livestock Production Science 36: 39–54CrossRefGoogle Scholar
Carver, A S, Dalrymple, M A, Wright, G, Cottom, D S, Reeves, D B, Gibson, Y H, Keenan, J L, Barrass, J D, Scott, A R, Colman, A and Garner, I 1993 Transgenic livestock as bioreactors: stable expression of human Alpha-1-Antitrypsin by a flock of sheep. Bio/ Technology 11: 1263–1270Google ScholarPubMed
Ebert, K M and Schindler, JES 1993 Transgenic farm animals - progress report. Theriogenology 39: 121–135CrossRefGoogle Scholar
Evans, J E, Gilmour, D T and Colledge, W H 1994 Transgenic rodents. In: N Maclean (ed) Animals with Novel Genes pp 138–178. Cambridge University Press: Cambridge, UKGoogle Scholar
Eyestone, W H 1994 Challenges and progress in the production of transgenic cattle. Reproduction Fertility and Development 6: 647–652CrossRefGoogle ScholarPubMed
MAFF 1995 MAFF Report of the Committee to Consider the Ethical Implications of Emerging Technologies in the Breeding of Farm Animals. Her Majesty’s Stationery Office: London, UKGoogle Scholar
Müller, M and Brem, G 1994 Transgenic strategies to increase disease resistance in livestock. Reproduction Fertility and Development 6: 605–613CrossRefGoogle ScholarPubMed
Palmiter, R D, Brinster, R L, Hammer, R E, Trumbauer, M E, Rosenfeld, M G, Birnberg, N C and Evans, R M 1982 Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300: 611–615CrossRefGoogle ScholarPubMed
Petters, R M 1994 Transgenic livestock as genetic models of human disease. Reproduction Fertility and Development 6: 643–645CrossRefGoogle ScholarPubMed
Poole, T B 1995 Welfare considerations with regard to transgenic animals. Animal Welfare 4: 81–85CrossRefGoogle Scholar
Powell, B C, Walker, S K, Bawden, C S, Sivaprasad, A V and Rogers, G E 1994 Transgenic sheep and wool growth: Possibilities and current status. Reproduction Fertility and Development 6: 615–623CrossRefGoogle ScholarPubMed
Robinson, J J and McEvoy, T G 1993 Biotechnology - the possibilities. Animal Production 57: 335–352Google Scholar
Romagnolo, D and Diaugustine, R P 1994 Transgenic approaches for modifying the mammary gland to produce therapeutic proteins. Environmental Health Perspectives 102: 846–851CrossRefGoogle ScholarPubMed
Smith, T J 1994 Commercial exploitation of transgenics. Biotechnology Advances 12: 679–686CrossRefGoogle ScholarPubMed
Stewart, T A, Hultgren, B, Huang, X, Pitts-Meek, S, Hully, J and MacLachlan, N J 1993 Induction of Type-I diabetes by interferon-alpha in transgenic mice. Science 260: 1942–1946CrossRefGoogle ScholarPubMed
van Reenen, C G and Blokhuis, H J 1993 Investigating welfare of dairy calves involved in genetic modification: problems and perspectives. Livestock Production Science 36: 81–90CrossRefGoogle Scholar
Wilmut, I and Whitelaw, C B A 1994 Strategies for production of pharmaceutical proteins in milk. Reproduction Fertility and Development 6: 625–630CrossRefGoogle ScholarPubMed
Woychik, R P, Wassom, J S and Kingsbury, D 1993 TBASE: a computerized database for transgenic animals and targeted mutations. Nature 363: 375–376CrossRefGoogle ScholarPubMed