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Relationships between pathology and pain severities: a review

Published online by Cambridge University Press:  01 January 2023

NG Gregory
NG Gregory*
Affiliation:
Royal Veterinary College, Hatfield, Herts AL9 7TA, UK; email: ngregory@rvc.ac.uk
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Abstract

The relationships between pathology severity and pain severity are reviewed using the literature available for humans. The aim is to help veterinary radiologists, physicians and pathologists recognise the disorders in which severity of a lesion is likely to be related to the severity of pain or to incipient pain. Specific features or lesions within the following conditions showed a relationship with pain score, which was usually assessed with a visual analogue scale: inflammation; pancreatitis; ileitis; mucositis; fasciitis; synovitis; arthritis; lower back pain; disc herniation; sciatica; scoliosis; myalgia; cancer; arteriosclerosis; skin ulcers; mastalgia; skin and oral neuropathies; endometriosis; hepatopathy and chronic pulp diseases of the teeth. As experience with magnetic resonance imaging grows, there will be further opportunities to look for quantitative relationships in humans between pathology and pain severities. This information will be useful to veterinarians and other people working with animals in evaluating pain in animals in their care.

Keywords

animal welfarecorrelationdiseasehumanpainpathology

Information

Type
Research Article
Information
Animal Welfare , Volume 19 , Issue 4 , November 2010, pp. 437 - 448
Copyright
© 2010 Universities Federation for Animal Welfare

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References

Akhan, O, Altinok, D, Özmen, MN, Oguzkurt, L and Besim, A 1997 Correlation between the grade of tumoral invasion and pain relief in patients with celiac ganglia block. American Journal of Roentgenology 168: 1565–1567CrossRefGoogle ScholarPubMed
Aota, Y, Onarii, K, An, H and Yoshikawa, K 2001 Dorsal root ganglia morphologic features in patients with herniation of the nucleus pulposus: assessment using magnetic resonance myelography and clinical correlation. Spine 26: 2125–2132CrossRefGoogle ScholarPubMed
Ashina, M, Bendtsen, L, Jensen, R, Sakai, F and Olesen, J 1999 Muscle hardness in patients with chronic tension-type headache: relation to actual headache state. Pain 79: 201–205CrossRefGoogle ScholarPubMed
Athiviraham, A, Yen, D, Scott, C and Soboleski, D 2007 Clinical correlation of radiological spinal stenosis after standardisation for vertebral body size. Clinical Radiology 62: 776–780CrossRefGoogle Scholar
Ay, S, Tur, BS and Küçükdeveci, A 2008 Evaluation of disability in patients with degenerative and inflammatory arthritis. International Journal of Rehabilitation Research 31: 159–163CrossRefGoogle ScholarPubMed
Ayral, X, Pickering, EH, Woodworth, TG, Mackillop, N and Dougados, M 2005 Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis - results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis and Cartilage 13: 361–367CrossRefGoogle ScholarPubMed
Bakke, M, Zak, M, Jensen, BL, Pedersen, FK and Kreiborg, S 2001 Orofacial pain, jaw function, and temperomandibular disorders in women with a history of juvenile chronic arthritis or persistent juvenile chronic arthritis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 92: 406–414CrossRefGoogle ScholarPubMed
Barker, KL, Shamley, DR and Jackson, D 2004 Changes in the cross-sectional area of multifidus and psoas in patients with unilateral back pain: the relationship to pain and disability. Spine 29: E515–E519CrossRefGoogle ScholarPubMed
Bonilla-Martinez, ZL, Allbrecht, J, Troxel, AB, Taylor, L, Okawa, J, Dulay, S and Werth, VP 2008 The cutaneous lupus erythematosus disease area and severity index. Archives of Dermatology 144: 173–180CrossRefGoogle ScholarPubMed
Brenner, SS, Klotz, U, Alscher, DM, Mais, A, Lauer, G, Schweer, H, Seyberth, HW, Fritz, P and Bierbach, U 2004 Osteoarthritis of the knee - clinical assessments and inflammatory markers. Osteoarthritis and Cartilage, 12: 469–475CrossRefGoogle ScholarPubMed
Brisby, H, Olmaker, K, Larsson, K, Nutu, M and Rydevik, B 2002 Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. European Spine Journal 11: 62–66CrossRefGoogle ScholarPubMed
Bruhlmann, Y and Tschopp, H 1998 Breast reduction improves symptoms of macromastia and has a long-lasting effect. Annals of Plastic Surgery 41: 240CrossRefGoogle Scholar
Buttermann, CR and Mullin, WJ 2008 Pain and disability correlated with disc degeneration via magnetic resonance imaging in scoliosis patients. European Spine Journal 17: 240–249CrossRefGoogle ScholarPubMed
Chang, C-W, Chen, Y-R and Chang, KF 2008 Evidence of neuroaxonal degeneration in myofascial pain syndrome: a study of neuromuscular jitter by axonal microstimulation. European Journal of Pain 12: 1026–1030CrossRefGoogle ScholarPubMed
Cisneros-Cabello, R and Segura-Egea, JJ 2005 Relationship of patient complaints and signs to histopathologic diagnosis of pulpal condition. Australian Endodontic Journal 31: 361–367CrossRefGoogle ScholarPubMed
Connelly, ST and Schmidt, BL 2004 Evaluation of pain in patients with oral squamous cell carcinoma. Journal of Pain 5: 505–510CrossRefGoogle ScholarPubMed
Coskun, E, Süzer, T, Topuz, O, Zencir, M, Pakdemirli, E and Tahta, K 2000 Relationship between epidural fibrosis, pain, disability, and psychological factors after lumbar disc surgery. European Spine Journal 9: 218–223CrossRefGoogle Scholar
Damon, L, Buyrik, HM, Güler-Uysal, F, Lotgering, FK, Snijders, CJ and Stam, HJ 2001 Pelvic pain during pregnancy is associated with asymmetric laxity of the sacroiliac joints. Acta Obstetrica et Gynecoligica Scandinavica 80: 1019–1024CrossRefGoogle Scholar
Dangaria, TR and Naesh, O 1998 Changes in cross-sectional area of psoas major muscle in unilateral sciatica caused by disc herniation. Spine 23: 928–931CrossRefGoogle ScholarPubMed
Devigili, G, Tugnoli, V, Penza, P, Camozzi, F, Lombardi, R, Melli, G, Broglio, L, Granieri, E and Lauria, G 2008 The diagnostic criteria for small fibre neuropathy. Brain 131: 1912–1925CrossRefGoogle ScholarPubMed
Di Sebastiano, P, Fink, T, Weihe, E, Friess, H, Innocenti, P, Beger, HG and Büchler, MW 1997 Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis. Gastroenterology 112: 1648–1655CrossRefGoogle ScholarPubMed
Duncan, R, Feat, G, Thomas, E, Hay, E, McCall, I and Croft, P 2007 Symptoms and radiographic osteoarthritis: not as discordant as they are made out to be. Annals of Rheumatic Disease 66: 86–91Google ScholarPubMed
Elias, I, Zoga, AC, Raikin, SM, Peterson, JR, Besser, MP, Morrison, WB and Schweitzer, ME 2008 Bone stress injury of the ankle in professional ballet dancers seen on MRI. BMC Musculoskeletal Disorders 9: 39Google Scholar
Ellingsen, T, Buus, A and Stengaard-Pedersen, K 2001 Plasma monocyte chemoattractant protein-1 is a marker for joint inflammation in rheumatoid arthritis. Journal of Rheumatology 28: 41–46Google ScholarPubMed
Emshoff, R, Innerhofer, K, Rudisch, A and Bertram, S 2002 The biological concept of ‘internal derangement and osteoarthritis’: A diagnostic approach in patients with temperomandibular joint pain? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 93: 39–44CrossRefGoogle Scholar
Erdogan, D, van Delden, OM, Rauws, EAJ, Busch, ORC, Lameris, JS, Gouma, DJ and van Gulik, TM 2007 Results of percutaneous scleropathy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease. World Journal of Gastroenterology 13: 3095–3100CrossRefGoogle Scholar
Evans, GFF, Haller, RG, Wyrick, PS, Parkey, RW and Fleckenstein, JL 1998 Submaximal delayed-onset muscle soreness: correlations between MR imaging findings and clinical measures. Radiology 208: 815–820CrossRefGoogle ScholarPubMed
Grapengiesser, S, Gudmendsson, F, Larkö, O, Ericson, M, Rosén, A and Wennberg, A-M 2002 Pain caused by photodynamic therapy of skin cancer. Clinical and Experimental Dermatology 27: 493–497CrossRefGoogle ScholarPubMed
Gregory, NG 2004 Physiology and Behaviour of Animal Suffering. Blackwell Publishing: Oxford, UKCrossRefGoogle Scholar
Grieco, CA, Simon, CJ, Mayo-Smith, WM, Di Petrillo, TA, Ready, NE and Dupny, DE 2007 Image-guided percutaneous thermal ablation for the palliative treatment of chest wall masses. American Journal of Clinical Oncology 30: 361–367CrossRefGoogle ScholarPubMed
Guarnera, G, Tinelli, G, Abeni, D, Pietro, CD, Sampogna, F and Fabolli, S 2007 Pain and quality of life in patients with vascular leg ulcers: an Italian multicentre study. Journal of Wound Care 16: 347–351CrossRefGoogle ScholarPubMed
Gupta, V, Chandrasekar, T, Ramani, P and Anuja, P 2006 Determining toothache severity in pediatric patients. Journal of Indian Society of Pedodontics and Preventive Dentistry 24: 140–143CrossRefGoogle ScholarPubMed
Gynther, GW, Holmlund, AB, Reinholt, FP and Lindblad, S 1997 Temperomandibular joint involvement in generalised osteoarthritis and rheumatoid arthritis: a clinical arthroscopic, histologic and immunohistochemical study. International Journal of Oral & Maxillofacial Surgery 26: 10–16CrossRefGoogle Scholar
Harris, JN, Robinson, P, Lawrence, J, Carrington, BM, Hopwood, P, Dougal, M and Makin, W 2003 Symptoms of colorectal liver metastases: correlation with CT findings. Clinical Oncology 15: 78–82CrossRefGoogle ScholarPubMed
Healy, PJ, Groves, C, Chandramohan, M and Helliwell, PS 2008 MRI changes in psoriatic dactylitis - extent of pathology, relationship to tenderness and correlation with clinical studies. Rheumatology 47: 92–95CrossRefGoogle Scholar
Helland, CA and Webster, K 2007 Intracystic pressure in patients with temporal arachnoid cysts: a prospective study of preoperative complaints and postoperative outcome. Journal of Neurology Neurosurgery and Psychiatry 78: 620–623CrossRefGoogle ScholarPubMed
Hill, CJ, Hunter, DJ, Niu, J, Clancy, M, Guermazi, A, Genant, H, Gale, D, Grainger, A, Canaghan, P and Felson, DT 2007 Synovitis, detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Annals of Rheumatic Diseases 66: 1599–1603CrossRefGoogle ScholarPubMed
Hirata, H, Tsujii, M, Yoshida, T, Yoshida, KI, Morita, A, Okuyama, N, Nagakura, T, Sugimoto, T, Fujisawa, K and Uchida, A 2005 MMP-2 expression is associated with rapidly proliferative arteriosclerosis in the flexor tenosynovium and pain severity in carpal tunnel syndrome. Journal of Pathology 205: 443–450CrossRefGoogle ScholarPubMed
Howlader, MH and Coleridge Smith, PD 2003 Symptoms of chronic venous disease and association with systemic inflammatory markers. Journal of Vascular Surgery 38: 950–954CrossRefGoogle ScholarPubMed
Hunter, DJ, Lo, GH, Gale, D, Grainger, AJ, Guermazi, A and Conaghan, PG 2008 The reliability of a new scoring system for knee osteoarthritis MRI and validity of bone marrow lesion assessments. Annals of Rheumatic Diseases 67: 206–211CrossRefGoogle Scholar
Hunter, DJ, March, L and Sambrook, PN 2003 The association of cartilage volume with knee pain. Osteoarthritis and Cartilage 11: 725–729CrossRefGoogle ScholarPubMed
Imasato, H, Nagata, K, Hashimoto, S, Komori, H and Inoue, A 1997 Objective evaluation of pain in various spinal diseases: neuropeptide immunoreactivity in the cerebrospinal fluid. Spinal Cord 35: 757–762CrossRefGoogle ScholarPubMed
Jensen, B, Wittrup, IH, Bliddal, H, Danneskiold-Sams⊘e, B and Faber, J 2003 Bone mineral density in fibromyalgia patients - correlations to disease activity. Scandinavian Journal of Rheumatology 32: 146–150CrossRefGoogle Scholar
Kadi, F, Waling, K, Ahlgren, C, Sundelin, G, Holmner, S, Butler-Browne, GS and Thornell, L-E 1998 Pathological mechanisms implicated in localized female trapezius myalgia. Pain 78: 191–196CrossRefGoogle ScholarPubMed
Kapural, L, Mekhail, N, Bena, J, McLain, R, Tetzlaff, J, Kapural, M, Mekhail, M and Polk, S 2007 Value of the magnetic resonance imaging in patients with painful lumbarspinal stenosis (LSS) undergoing lumbar epidural steroid injections. Clinical Journal of Pain 23: 571–575CrossRefGoogle Scholar
Kenny, TJ, Duncavage, J, Bracikowski, J, Yildirim, A, Murray, JJ and Tanner, SB 2001 Prospective analysis of sinus symptoms and correlation with paranasal computed tomography scan. Otolaryngology — Head and Neck Surgery 125: 40–43CrossRefGoogle ScholarPubMed
Kettunen, TA, Visuri, T, Harilainen, A, Sandelin, J and Kujala, UM 2005 Primary cartilage lesions and outcome among subjects with patella femoral pain syndrome. Knee Surgery Sports Traumatology Arthroscopy 13: 131–134CrossRefGoogle Scholar
Kurunlahti, M, Karppinen, J, Haapea, M, Niinmäki, J, Autio, R, Vanharanta, H, Suramo, I and Tervonen, O 2004 Three-year follow up of lumbar artery occlusion with magnetic resonance angiography in patients with sciatica: associations between occlusion and patient-reported symptoms. Spine 29: 1804–1808CrossRefGoogle ScholarPubMed
Lee, CJ, Scheiman, J, Andersen, MA, Hines, OJ, Reber, HA, Farrell, J, Kochman, ML, Foley, PJ, Drebin, J, Oh, YS, Ginsberg, G, Ahmad, N, Merchant, NB, Isbell, J, Parikh, AA, Stokes, JB, Bauer, T, Adams, RB and Simeone, DM 2008 Risk of malignancy in resected cystic tumors of the pancreas ≤ 3 cm in size. Journal of Gastrointestinal Surgery 12: 234–242CrossRefGoogle ScholarPubMed
Lindh, C, Liu, Z, Lyrenäs, S, Ordeberg, G and Nyberg, F 1997 Elevated cerebrospinal fluid substance P-like immunoreactivity in patients with painful osteoarthritis, but not in patients with rhizopatic pain from a herniated lumbar disc. Scandinavian Journal of Rheumatology 26: 468–472CrossRefGoogle Scholar
Link, TM, Steinbach, LS, Ghosh, S, Ries, M, Lu, Y, Lane, N and Majumdar, S 2003 Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226: 373–381CrossRefGoogle ScholarPubMed
Mazzuca, SA, Brandt, KD, Lane, KA and Katz, BP 2002 Knee pain reduces joint space width in conventional standing anteroposterior radiographs of osteoarthritic knees. Arthritis and Rheumatism 46: 1223–1227CrossRefGoogle ScholarPubMed
McBeth, SB and Gratt, BM 1996 Thermographic assessment of temperomandibular disorders symptomatology during orthodontic treatment. American Journal of Orthodontics and Dentofacial Orthopedics 109: 481–488CrossRefGoogle Scholar
Mohammadian, P, Andersen, OK and Arendt-Nielsen, L 1998 Correlation between local vascular and sensory changes following tissue inflammation induced by repetitive application of topical capsaicin. Brain Research 729: 1–9CrossRefGoogle Scholar
Muzii, L, Marana, R, Pedullà, S, Catalano, GF, and Mancuso, S 1997 Correlation between endometriosis-associated dysmenorrhea and the presence of typical or atypical lesions. Fertility and Sterility 68: 19–22CrossRefGoogle ScholarPubMed
Nam, KW, Kim, YL, Yoo, JJ, Koo, K-H, Yoon, KS and Kim, HJ 2008 Fate of untreated asymptomatic osteonecrosis of the femoral head. Journal of Bone and Joint Surgery of America 90: 477–484CrossRefGoogle ScholarPubMed
Ng, Y-L, Glennon, JP, Setchell, DJ and Gulabivala, K 2004 Prevalence of and factors affecting post-obturation pain in patients undergoing root canal treatment. International Endodontic Journal 37: 381–391CrossRefGoogle ScholarPubMed
Nishi, T, Sugano, N, Ohzono, K, Sakai, T, Haraguchi, K and Yoshikawa, H 2002 Progression and cessation of collapse in osteonecrosis of the femoral head. Clinical Orthopaedics and Related Research 400: 149–157CrossRefGoogle Scholar
Oaklander, AL, Romans, K, Horasek, S, Stocks, A, Hauer, P and Meyer, RA 1998 Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage. Annals of Neurology 44: 789–795Google ScholarPubMed
Okusaka, T, Okada, S, Ueno, H, Ikeda, M, Shimada, K, Yamamoto, J, Kosuge, T, Yamasaki, S, Fukushima, N and Sakamoto, M 2001 Abdominal pain in patients with resectable pancreatic cancer with reference to clinicopathologic findings. Pancreas 22: 279–284CrossRefGoogle ScholarPubMed
O’Neill, TW, McCloskey, EV, Kanis, JA, Bhalla, AK, Reeve, J, Reid, DM, Todd, C, Woolf, AD and Silman, AJ 1999 The distribution, determinants, and clinical correlates of vertebral osteophytosis: a population based survey. Journal of Rheumatology 26: 842–848Google ScholarPubMed
Peters, F, Diemer, P, Mecks, O and Behnken, LJ 2003 Severity of mastalgia in relation to milk duct dilatation. Obstetrics and Gynecology 101: 54–60Google ScholarPubMed
Phillips, C, Blakey, G and Jaskolka, M 2008 Recovery after orthognathic surgery: short-term health-related quality of life outcomes. Journal of Oral and Maxillofacial Surgery 66: 2110–2115CrossRefGoogle ScholarPubMed
Polydefkis, M, Yinnoutsos, CT, Cohen, BA, Hollander, H, Schifitto, G, Clifford, DB, Simpson, DM, Katzenstein, D, Shriver, S, Hauer, P, Brown, A, Haidich, AB, Moo, L and McArthur, JC 2002 Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 58: 115–119CrossRefGoogle ScholarPubMed
Prantera, C, Luzi, C, Olivotto, P, Levenstein, S, Cerro, P and Fanucci, A 1984 Relationship between clinical and laboratory parameters and length of lesion in Crohn's Disease of small bowel. Digestive Diseases and Sciences 12: 1093–1097CrossRefGoogle Scholar
Pye, SR, Reid, DM, Smith, R, Adams, JE, Nelson, K, Silman, AJ and O’Neill, TW 2004 Radiographic feature of lumbar disc degeneration and self-reported pain. Journal of Rheumatology 31: 753–758Google Scholar
Raynauld, J-P, Martel-Pelletier, J, Berthiaume, M-J, Beaudoin, G, Choquette, D, Haraoui, B, Tennenbaum, H, Meyer, JM, Beary, JF, Cline, GA and Pelletier, J-P 2006 Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes. Arthritis Research and Therapy 8(R21): 1–12Google ScholarPubMed
Rowbotham, MC, Yosipovitch, G, Connolly, MK, Finlay, D, Forde, G and Fields, HL 1996 Cutaneous innervations density in the allodynic form of postherpetic neuralgia. Neurobiology of Disease 3: 205–214CrossRefGoogle Scholar
Sammour, A, Pirwany, I, Usubutun, A and Arseneau, J 2002 Correlations between extent and spread of adenomyosis and clinical symptoms. Gynecologic and Obstetric Investigation 54: 213–216CrossRefGoogle ScholarPubMed
Sandberg, C, Stenquist, B, Rosdahl, I, Ros, A-M, Synnerstadt, I, Karlsson, M, Gudmundson, F, Ericson, MM, Larkö, O and Wennberg, A-M 2006 Important factors for pain during photodynamic therapy for actinic keratosis. Acta Dermato-Venereologica 86: 404–408CrossRefGoogle ScholarPubMed
Sarikaya S, Özdolap Ş, Gümüştaş Ş and Kroç Ü 2007 Low back pain and lumbar angles in Turkish coal miners. American Journal of Industrial Medicine 50: 92–96CrossRefGoogle Scholar
Sato, J, Segami, N, Kaneyama, K, Yoshimura, H, Fujimura, K and Yoshitake, Y 2004 Relationship of calcitonin gene-related peptide in synovial tissues and temperomandibular joint pain in humans. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 98: 533–540CrossRefGoogle Scholar
Schierz, O, John, MT, Schroeder, E and Lobbezoo, F 2007 Association between anterior tooth wear and temperomandibular disorder pain in a German population. Journal of Prosthetic Dentistry 97: 305–309CrossRefGoogle Scholar
Schlossbauer, T, Mioc, T, Sommerey, S, Kessler, SB, Reiser, MF and Pfeifer, KJ 2008 Magnetic resonance imaging in early charcot arthropathy - correlation of imaging findings and clinical symptoms. European Journal of Medical Research 13: 409–414Google ScholarPubMed
Schmidt-Wilcke, T, Leinisch, E, Gänßbauer, S, Draganski, B, Bogdahn, U, Altmeppen, J and May, A 2006 Affective components and intensity of pain correlate with structural differences in grey matter in chronic back pain patients. Pain 125: 89–97CrossRefGoogle ScholarPubMed
Schwab, F, Smith, VA, Biserni, M, Gamez, L, Farcy, J-P and Pagala, M 2002 Adult scoliosis: a quantitative radiographic and clinical analysis. Spine 27: 387–392CrossRefGoogle ScholarPubMed
Schwimmer, JB, Deutsh, R, Rauch, JB, Behling, C, Newbury, R and Lavine, JE 2003 Obesity, insulin-resistance, and other clinicopathological correlates of pediatric non-alcoholic fatty liver disease. Journal of Pediatrics, 143: 500–505CrossRefGoogle Scholar
Scuderi, GJ, Brusovanik, GV, Golish, SR, DeMeo, R, Hyde, J, Hallab, N and Vaccaro, AR 2008 A critical evaluation of discography in patients with lumbar intervertebral disc disease. Spine Journal 8: 624–629CrossRefGoogle ScholarPubMed
Şenocak, O, DeÐirmenci, B, ÖzdoÐan, Ö, Akalia, E, Arslam, G, Kaner, B, Taşci, C and Peker, Ö 2002 Technetium-99m human immunoglobulin scintigraphy in patients with adhesive capsulitis: a correlative study with bone scintigraphy. Annals of Nuclear Medicine 16: 243–248CrossRefGoogle ScholarPubMed
Sharp, RJ, Wade, CM, Hennessey, MS and Saxby, TS 2003 The role of MRI and ultrasound imaging in Morton's neuroma and the effect of size of lesion on symptoms. Bone and Joint Surgery 85B: 999–1005CrossRefGoogle Scholar
Shimada, Y, Miyahoshi, N, Kasukawa, Y, Hongo, M, Ando, S and Itoi, E 2006 Clinical features of cauda equine tumors requiring surgical treatment. Tohoku Journal of Experimental Medicine 209: 1–6CrossRefGoogle Scholar
Sjöström, M, Ängquist, K-A and Rais, O 1980 Intermittent claudication and muscle fiber fine structure: correlation between clinical and morphological data. Ultrastructural Pathology 1: 309–326CrossRefGoogle ScholarPubMed
Song, IH, Althoff, CE, Hermann, KG, Scheel, AK, Knetsch, T, Schoenharting, M, Werner, C, Burmester, GR and Backhaus, M 2008 Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging. Annals of Rheumatic Diseases 67: 19–25CrossRefGoogle ScholarPubMed
Song, IH, Althoff, CE, Hermann, KG, Scheel, AK, Knetsch, T, Burmester, GR and Backhaus, M 2009 Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI. Annals of Rheumatic Diseases 68: 75–83.CrossRefGoogle ScholarPubMed
Sonis, ST, Eilers, JP, Epstein, JB, Le Veque, FG, Liggett, WH, Mulagha, MT, Peterson, DE, Rose, AH, Schubert, MM, Spijkervet, FK and Wittes, JP 1999 Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Cancer 85: 2103–21133.0.CO;2-0>CrossRefGoogle ScholarPubMed
Suenaga, S, Abeyama, K, Hamasaki, A, Mimura, T and Noikura, T 2001 Temperomandibular disorders: relationship between joint pain and effusion and nitric oxide concentration in the joint fluid. Dentomaxillofacial Radiology 30: 214–218CrossRefGoogle Scholar
Suzuki, T, Segami, N, Kaneyama, K, Nishimura, M and Nojima, T 1999 Specific expression of interleukin-1β in temperomandibular joints with internal derangement. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 88: 413–417CrossRefGoogle Scholar
Taljanovic, M, Graham, AR, Benjamin, JB, Gmitro, AF, Krupinski, EA, Schwartz, SA, Hunter, TB and Resnick, DL 2008 Bone marrow oedema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology. Skeletal Radiology 37: 423–431CrossRefGoogle ScholarPubMed
Tanigawa, N, Komemushi, A, Kariya, H, Shomura, Y, Ikeda, K, Omura, N, Murakami, T and Sawada, S 2006 Percutaneous vertebroplasty: relationship between vertebral body bone marrow oedema pattern on MR images and initial clinical response. Radiology 239: 195–200CrossRefGoogle ScholarPubMed
Terslev, L, Torp-Pedersen, S, Qvistgaard, E and Bliddal, H 2003 Spectral Doppler and resistive index. A promising tool in ultrasonographic evaluation of inflammation in rheumatoid arthritis. Acta Radiologica 44: 645–652Google Scholar
Toffolo, SR, Furtado, RN, Klein, A, Watanabe, S, Andrade, LE and Natour, J 2008 Measurement of upper limb ulcers in patients with systematic sclerosis: reproducibility and correlation with pain, function, and quality of life. Nursing Research 57: 84–92CrossRefGoogle Scholar
van de Sande, MAJ, de Groot, JH and Rozing, PM 2008 Clinical implications of rotator cuff degeneration in the rheumatic shoulder. Arthritis and Rheumatism 59: 317–324CrossRefGoogle ScholarPubMed
van Tulder, MW, Assendelft, WJJ, Koes, BW and Bouter, LM 1997 Spinal radiographic findings and nonspecific low back pain: a systematic review of observational studies. Spine 22: 427–434Google ScholarPubMed
Vassiliou, V, Kalogeropoulou, C, Petsas, T, Leotsinidis, M and Kardamakis, D 2007 Clinical and radiological evaluation of patients with lytic, mixed and sclerotic bone metastases from solid tumors: is there a correlation between clinical status of patients and type of bone metastases? Clinical and Experimental Metastasis 24: 49–56CrossRefGoogle Scholar
Vercellini, P, Fedele, L, Aimi, G, Pietropaolo, G, Consonni, D and Crosignani, PG 2007 Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients. Human Reproduction 22: 266–271CrossRefGoogle ScholarPubMed
Vlčková-Moravcová, E, Bednărík, J, Dušek, L, Toyka, KV and Sommer, C 2008 Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Muscle and Nerve 37: 50–60CrossRefGoogle ScholarPubMed
Wabnitz, DAM, Nair, S and Wormald, PJ 2005 Correlation between preoperative symptom scores, quality-of-life questionnaires, and staging with computed tomography in patients with chronic rhinosinusitis. American Journal of Rhinology 19: 91–96CrossRefGoogle ScholarPubMed
Wall, PD, Melzack, R and Bonica, JJ 1994 Textbook of Pain, Third Edition. Churchill Livingstone: Edinburgh, UKGoogle Scholar
Wallny, T, Lattaye, L, Brackmann, HH, Heß, L, Seuser, A and Kraft, CN 2005 Clinical and radiographic scores in haemophilic arthropathies: how well do these correlate to subjective pain status and daily activities? Haemophilia 8: 802–818CrossRefGoogle Scholar
Walther, M, Radke, S, Kirschner, S, Ettl, V and Gohlke, F 2004 Power Doppler findings in plantar fasciitis. Ultrasound in Medicine and Biology 30: 435–440CrossRefGoogle ScholarPubMed
Watanabe, K, Hasegawa, K, Hirano, T, Uchiyama, S and Endo, N 2005 Use of scoliosis research society outcomes instrument to evaluate patient outcome in untreated idiopathic scoliosis patients in Japan. Spine 30: 1202–1205CrossRefGoogle ScholarPubMed
Yilmaz, Z, Renton, T, Yiangou, Y, Zakrzewska, J, Chessell, IP, Bountra, C and Anand, P 2007 Burning mouth syndrome as trigeminal small fibre neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. Journal of Clinical Neuroscience 14: 64–871CrossRefGoogle ScholarPubMed
Yun, TJ, Lee, HJ, Kim, SH, Lee, SE, Hong, SK, Cho, JY and Seong, CK 2007 Prospective analysis on the relation between pain and prostate volume during transrectal prostate biopsy. Korean Journal of Radiology 8: 231–235Google ScholarPubMed