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Poststroke nutrition - part 1

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SD.Poppitt et al. Effects of moderate-dose omega-3 fish oil on cardiovascular risk factors and mood after ischemic stroke: a randomized, controlled trial. Stroke. 2009 Nov;40(11):3485–92.
F.Garbagnati et al. Is antioxidant and n-3 supplementation able to improve functional status in poststroke patients? Results from the Nutristroke Trial. Cerebrovasc Dis. 2009;27(4):375–83.
R.Aquilani et al. Normalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokes. Nutr Neurosci. 2009 Oct;12(5):219–25.

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

After a stroke, the body may have to deal with ischaemic damage, inflammation, oxidation and hyperglycaemia. Nutrients that can help counter these processes include antioxidant and B vitamins, zinc and magnesium, as well as careful glycaemic control.

There is some RCT evidence to support such treatments, but as yet not enough to provide solid confirmation of their validity.

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Brief Report
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Arbor Clinical Nutrition Updates , Volume 320 , April 2010, pp. 1 - 5
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Copyright © Cambridge University Press 2010

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References

References:

1. Kidd, PM. Integrated brain restoration after ischemic stroke-medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity. Altern Med Rev. 2009 Mar;14(1):14–35.Google ScholarPubMed
2. Cherubini, A. et al. Dietary antioxidants as potential pharmacological agents for ischemic stroke. Curr Med Chem. 2008;15(12):1236–48.CrossRefGoogle ScholarPubMed
3. Paolino, AS. et al. Effects of hyperglycemia on neurologic outcome in stroke patients. J Neurosci Nurs. 2005 Jun;37(3):130–5.CrossRefGoogle ScholarPubMed
4. Gariballa, S. Editorial comment: Protein-energy undernutrition and acute stroke outcome. Stroke. 2003 Jun;34(6):1455–6.CrossRefGoogle ScholarPubMed
5. Kleinig, TJ. et al. Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options. Curr Opin Neurol. 2009 Jun;22(3):294–301.CrossRefGoogle Scholar
6. Carmichael, ST. Themes and strategies for studying the biology of stroke recovery in the poststroke epoch. Stroke. 2008 Apr;39(4):1380–8.CrossRefGoogle ScholarPubMed
7. Gee, JM. et al. Lymphocytes: potential mediators of postischemic injury and neuroprotection. Stroke. 2007 Feb;38(2 Suppl):783–8.CrossRefGoogle ScholarPubMed
8. Endres, M. et al. Targeting eNOS for stroke protection. Trends Neurosci. 2004 May;27(5):283–9.CrossRefGoogle ScholarPubMed
9. Sims, NR. et al. Mitochondrial contributions to tissue damage in stroke. Neurochem Int. 2002 May;40(6):511–26.CrossRefGoogle ScholarPubMed
10. Pan, J. et al. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007 Feb;49(2):93–102.CrossRefGoogle ScholarPubMed
11. Aarts, MM. et al. Novel concepts in excitotoxic neurodegeneration after stroke. Expert Rev Mol Med. 2003 Dec 16;5(30):1–22.CrossRefGoogle ScholarPubMed
12. Endres, M. et al. [Apoptosis and ischemic infarct] Nervenarzt. 1998 Jun;69(6):459–64.CrossRefGoogle Scholar
13. Marín, J. et al. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol Ther. 1997 Aug;75(2):111–34.CrossRefGoogle ScholarPubMed
14. Cramer, SC. et al. Neuroplasticity and brain repair after stroke. Curr Opin Neurol. 2008 Feb;21(1):76–82.CrossRefGoogle ScholarPubMed
15. Macko, RF. et al. Task-oriented aerobic exercise in chronic hemiparetic stroke: training protocols and treatment effects. Top Stroke Rehabil. 2005 Winter;12(1):45–57.CrossRefGoogle ScholarPubMed
16. Carda, S. et al. Osteoporosis after stroke: a review of the causes and potential treatments. Cerebrovasc Dis. 2009;28(2):191–200.CrossRefGoogle ScholarPubMed
17. Chang, CY. et al. Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. Nutrition. 2005 Oct;21(10):987–93.CrossRefGoogle ScholarPubMed
18. Helman, AD. Stroke prevention - other nutrients. Arb Clin Nutr Upd. 2010 Apr;319:1–6.Google Scholar
19. Ullegaddi, R. et al. Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke. Eur J Clin Nutr. 2005 Dec;59(12):1367–73.CrossRefGoogle ScholarPubMed
20. Ullegaddi, R. et al. B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke. Clin Sci (Lond). 2004 Nov;107(5):477–84.CrossRefGoogle ScholarPubMed
21. Helman, AD. Stroke and prevention - B vitamins. Arb Clin Nutr Upd. 2010 Mar;318:1–5.Google Scholar
22. Bayir, A. et al. Acute-phase vitamin B12 and folic acid levels in patients with ischemic and hemorrhagic stroke: is there a relationship with prognosis? Neurol Res. 2010 Mar;32(2):115–8.CrossRefGoogle Scholar
23. Salemi, G. et al. Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B(12) in the acute phase of atherothrombotic stroke. Neurol Sci. 2009 May 30.Google Scholar
24. Newman, GC. et al. Association of diabetes, homocysteine, and HDL with cognition and disability after stroke. Neurology. 2007 Nov 27;69(22):2054–62.CrossRefGoogle ScholarPubMed
25. Alam, MM. et al. Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis. J Cereb Blood Flow Metab. 2009 Jan;29(1):157–65.CrossRefGoogle ScholarPubMed
26. Hwang, IK. et al. Folic acid deficiency increases delayed neuronal death, DNA damage, platelet endothelial cell adhesion molecule-1 immunoreactivity, and glsxiosis in the hippocampus after transient cerebral ischemia. J Neurosci Res. 2008 Jul;86(9):2003–15.CrossRefGoogle ScholarPubMed
27. Huang, GW. et al. [Effects of folic acid, vitamin B(6) and vitamin B(12) on learning and memory function in cerebral ischemia rats] Zhonghua Yu Fang Yi Xue Za Zhi. 2007 May;41(3):212–4.Google Scholar
28. Hoane, MR. et al. Administration of riboflavin improves behavioral outcome and reduces edema formation and glial fibrillary acidic protein expression after traumatic brain injury. J Neurotrauma. 2005 Oct;22(10):1112–22.CrossRefGoogle ScholarPubMed
29. Betz, AL. et al. Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:314–7.Google ScholarPubMed
30. Dusitanond, P. et al. Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy of the VITATOPS trial. Stroke. 2005 Jan;36(1):144–6.CrossRefGoogle ScholarPubMed
31. Sensi, SL. et al. Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci. 2009 Nov;10(11):780–91.CrossRefGoogle ScholarPubMed
32. Bitanihirwe, BK. et al. Zinc: the brain's dark horse. Synapse. 2009 Nov;63(11):1029–49.CrossRefGoogle ScholarPubMed
33. Nakashima, AS. et al. Zinc and cortical plasticity. Brain Res Rev. 2009 Mar;59(2):347–73.CrossRefGoogle ScholarPubMed
34. Paoletti, P. et al. Zinc at glutamatergic synapses. Neuroscience. 2009 Jan 12;158(1):126–36.CrossRefGoogle ScholarPubMed
35. Di Cello, F. et al. Divergent effects of zinc depletion in brain vs non-brain endothelial cells. Biochem Biophys Res Commun. 2005 Sep 23;335(2):373–6.CrossRefGoogle ScholarPubMed
36. Ganea, E. et al. Matrix metalloproteinases: useful and deleterious. Biochem Soc Trans. 2007 Aug;35(Pt 4):689–91.CrossRefGoogle ScholarPubMed
37. Bell, SG. et al. The metallothionein/thionein system: an oxidoreductive metabolic zinc link. Chembiochem. 2009 Jan 5;10(1):55–62.CrossRefGoogle ScholarPubMed
38. Lee, JY. et al. Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection. J Neurosci. 2008 Oct 22;28(43):10919–27.CrossRefGoogle ScholarPubMed
39. Galasso, SL. et al. The role of zinc in cerebral ischemia. Mol Med. 2007 Jul-Aug;13(7-8):380–7.CrossRefGoogle ScholarPubMed
40. Levenson, CW. Zinc supplementation: neuroprotective or neurotoxic? Nutr Rev. 2005 Apr;63(4):122–5.CrossRefGoogle ScholarPubMed
41. Capasso, M. et al. Zinc dyshomeostasis: a key modulator of neuronal injury. J Alzheimers Dis. 2005 Nov;8(2):93–108.CrossRefGoogle ScholarPubMed
42. Frederickson, CJ. et al. Zinc and excitotoxic brain injury: a new model. Neuroscientist. 2004 Feb;10(1):18–25.CrossRefGoogle ScholarPubMed
43. Weiss, JH. et al. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci. 2000 Oct;21(10):395–401.CrossRefGoogle ScholarPubMed
44. Choi, DW. et al. Zinc and brain injury. Annu Rev Neurosci. 1998;21:347–75.CrossRefGoogle ScholarPubMed
45. Diener, HC. et al. DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke. Stroke. 2008 Jun;39(6):1774–8.CrossRefGoogle ScholarPubMed
46. Wood, RJ. Assessment of marginal zinc status in humans. J Nutr. 2000 May;130(5S Suppl):1350S–4S.CrossRefGoogle ScholarPubMed
47. Gibson, RS. et al. Indicators of zinc status at the population level: a review of the evidence. Br J Nutr. 2008 Jun;99 Suppl 3:S14–23.CrossRefGoogle Scholar
48. Nguemeni, C. et al. Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke. Pharmacol Res. 2010 Mar;61(3):226–33.CrossRefGoogle Scholar
49. Ozen, OA. et al. The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex. Neurol Sci. 2008 Jun;29(3):147–52.CrossRefGoogle ScholarPubMed
50. Park, Y. et al. Dietary n-3 polyunsaturated fatty acids increase oxidative stress in rats with intracerebral hemorrhagic stroke. Nutr Res. 2009 Nov;29(11):812–8.CrossRefGoogle ScholarPubMed
51. Barbagallo, M. et al. Magnesium homeostasis and aging. Magnes Res. 2009 Dec;22(4):235–46.Google ScholarPubMed
52. Lampl, Y. et al. Cerebrospinal fluid magnesium level as a prognostic factor in ischaemic stroke. J Neurol. 1998 Sep;245(9):584–8.CrossRefGoogle ScholarPubMed
53. Ovbiagele, B. et al. Are elevated admission calcium levels associated with better outcomes after ischemic stroke? Neurology. 2006 Jul 11;67(1):170–3.CrossRefGoogle ScholarPubMed
54. van den Bergh, WM. et al. Electrocardiographic abnormalities and serum magnesium in patients with subarachnoid hemorrhage. Stroke. 2004 Mar;35(3):644–8.CrossRefGoogle ScholarPubMed
55. Chan, MT. et al. Magnesium sulfate for brain protection during temporary cerebral artery occlusion. Acta Neurochir Suppl. 2005;95:107–11.CrossRefGoogle ScholarPubMed
56. Lampl, Y. et al. Intravenous administration of magnesium sulfate in acute stroke: a randomized double-blind study. Clin Neuropharmacol. 2001 Jan-Feb;24(1):11–5.CrossRefGoogle ScholarPubMed
57. Schmid-Elsaesser, R. et al. Intravenous magnesium versus nimodipine in the treatment of patients with aneurysmal subarachnoid hemorrhage: a randomized study. Neurosurgery. 2006 Jun;58(6):1054–65.CrossRefGoogle ScholarPubMed
58. van den Bergh, WM. et al. Magnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial. Stroke. 2005 May;36(5):1011–5.CrossRefGoogle ScholarPubMed
59. Muir, KW. et al. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet. 2004 Feb 7;363(9407):439–45.Google ScholarPubMed
60. Aslanyan, S. et al. Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial. Stroke. 2007 Apr;38(4):1269–73.CrossRefGoogle ScholarPubMed
61. Saver, JL. et al. Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial. Stroke. 2004 May;35(5):e106–8.CrossRefGoogle ScholarPubMed
62. Meloni, BP. et al. Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies. Magnes Res. 2006 Jun;19(2):123–37.Google ScholarPubMed
63. Meloni, BP. et al. In search of clinical neuroprotection after brain ischemia: the case for mild hypothermia (35 degrees C) and magnesium. Stroke. 2009 Jun;40(6):2236–40.CrossRefGoogle ScholarPubMed
64. Allport, L. et al. Frequency and temporal profile of poststroke hyperglycemia using continuous glucose monitoring. Diabetes Care. 2006 Aug;29(8):1839–44.CrossRefGoogle ScholarPubMed
65. Scott, JF. et al. Glucose and insulin therapy in acute stroke; why delay further? QJM. 1998 Jul;91(7):511–5.CrossRefGoogle Scholar
66. O'Neill, PA. et al. Stress hormone and blood glucose response following acute stroke in the elderly. Stroke. 1991 Jul;22(7):842–7.CrossRefGoogle ScholarPubMed
67. Quinn, TJ. et al. Hyperglycaemia in acute stroke--to treat or not to treat. Cerebrovasc Dis. 2009;27 Suppl 1:148–55.CrossRefGoogle ScholarPubMed
68. McCormick, MT. et al. Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke. 2008 Jul;39(7):2177–85.CrossRefGoogle Scholar
69. Levetan, CS. Effect of hyperglycemia on stroke outcomes. Endocr Pract. 2004 Mar-Apr;10 Suppl 2:34–9.CrossRefGoogle ScholarPubMed
70. Garg, R. et al. Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke. 2006 Jan;37(1):267–73.CrossRefGoogle ScholarPubMed
71. Van den Berghe, G. et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes. 2006 Nov;55(11):3151–9.CrossRefGoogle ScholarPubMed
72. Pittas, AG. et al. Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials. Arch Intern Med. 2004 Oct 11;164(18):2005–11.CrossRefGoogle ScholarPubMed
73. Kreisel, SH. et al. Pragmatic management of hyperglycaemia in acute ischaemic stroke: safety and feasibility of intensive intravenous insulin treatment. Cerebrovasc Dis. 2009;27(2):167–75.CrossRefGoogle ScholarPubMed
74. Bruno, A. et al. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke. 2008 Feb;39(2):384–9.CrossRefGoogle Scholar
75. Vriesendorp, TM. et al. Efficacy and safety of two 5 day insulin dosing regimens to achieve strict glycaemic control in patients with acute ischaemic stroke. J Neurol Neurosurg Psychiatry. 2009 Sep;80(9):1040–3.CrossRefGoogle ScholarPubMed
76. Gray, CS. et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol. 2007 May;6(5):397–406.CrossRefGoogle ScholarPubMed
77. Lee, LT. Glycemic control in the diabetic patient after stroke. Crit Care Nurs Clin North Am. 2009 Dec;21(4):507–15.CrossRefGoogle ScholarPubMed
78. Bruno, A. Management of hyperglycemia during acute stroke. Curr Cardiol Rep. 2009 Jan;11(1):36–41.CrossRefGoogle ScholarPubMed