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Stroke prevention - other nutrients

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PC.Hollman et al. Dietary flavonol intake may lower stroke risk in men and women. J Nutr. 2010 Mar;140(3):600–4.
P.Strazzullo et al. Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ. 2009 Nov 24;339:b4567.
R.De Caterina et al. Cholesterol-lowering interventions and stroke: insights from a meta-analysis of randomized controlled trials. J Am Coll Cardiol. 2010 Jan 19;55(3):198–211.

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Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Observational evidence links many of the nutritional factors associated with atherosclerosis and hypertension to risk of stroke, e.g. calcium/vitamin D, antioxidants, PUFA, salt restriction, Mediterranean diet etc.

Only a minority of RCTs using nutrition to prevent stroke had significant benefit. This may be due to methodological issues.

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Brief Report
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Arbor Clinical Nutrition Updates , Volume 319 , April 2010, pp. 1 - 6
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Copyright © Cambridge University Press 2010

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References

References:

1. Helman, AD. Stroke and prevention - B vitamins. Arb Clin Nutr Upd. 2010 Mar;318:1–5.Google Scholar
2. Myint, PK. et al. Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr. 2008 Jan;87(1):64–9.CrossRefGoogle Scholar
3. Hirvonen, T. et al. Intake of flavonoids, carotenoids, vitamins C and E, and risk of stroke in male smokers. Stroke. 2000 Oct;31(10):2301–6.CrossRefGoogle Scholar
4. Leppälä, JM. et al. Different risk factors for different stroke subtypes: association of blood pressure, cholesterol, and antioxidants. Stroke. 1999 Dec;30(12):2535–40.CrossRefGoogle ScholarPubMed
5. Cherubini, A. et al. Dietary antioxidants as potential pharmacological agents for ischemic stroke. Curr Med Chem. 2008;15(12):1236–48.CrossRefGoogle ScholarPubMed
7. De Keyser, J. et al. Serum concentrations of vitamins A and E and early outcome after ischaemic stroke. Lancet. 1992 Jun 27;339(8809):1562–5.CrossRefGoogle Scholar
8. De Rosa, S. et al. Reactive oxygen species and antioxidants in the pathophysiology of cardiovascular disease: does the actual knowledge justify a clinical approach? Curr Vasc Pharmacol. 2010 Mar;8(2):259–75.CrossRefGoogle ScholarPubMed
9. Cook, NR. et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med. 2007 Aug 13–27;167(15):1610–8.CrossRefGoogle Scholar
10. Leppälä, JM. et al. Vitamin E and beta carotene supplementation in high risk for stroke: a subgroup analysis of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Arch Neurol. 2000 Oct;57(10):1503–9.CrossRefGoogle ScholarPubMed
11. Törnwall, ME. et al. Postintervention effect of alpha tocopherol and beta carotene on different strokes: a 6-year follow-up of the Alpha Tocopherol, Beta Carotene Cancer Prevention Study. Stroke. 2004 Aug;35(8):1908–13.CrossRefGoogle Scholar
12. Steiner, M. et al. Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks. Am J Clin Nutr. 1995 Dec;62(6 Suppl):1381S–1384S.CrossRefGoogle ScholarPubMed
13. Jandak, J. et al. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood. 1989 Jan;73(1):141–9.CrossRefGoogle ScholarPubMed
14. Kappus, H. et al. Tolerance and safety of vitamin E: a toxicological position report. Free Radic Biol Med. 1992;13(1):55–74.CrossRefGoogle ScholarPubMed
15. Wang, JS. et al. Vitamin E suppresses enhancement of factor VIII-dependent thrombin generation by systemic hypoxia. Stroke. 2009 Feb;40(2):656–9.CrossRefGoogle ScholarPubMed
16. Lee, IM. et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA. 2005 Jul 6;294(1):56–65.CrossRefGoogle ScholarPubMed
17. Slemmer, JE. et al. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem. 2008;15(4):404–14.Google ScholarPubMed
18. Li, L. et al. The effects of retinoic acid on the expression of neurogranin after experimental cerebral ischemia. Brain Res. 2008 Aug 21;1226:234–40.Google Scholar
19. Kelly, PJ. et al. Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Stroke. 2008 Jan;39(1):100–4.CrossRefGoogle ScholarPubMed
20. Sánchez-Moreno, C. et al. Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. Stroke. 2004 Jan;35(1):163–8.CrossRefGoogle ScholarPubMed
21. Gariballa, SE. et al. Antioxidant capacity after acute ischaemic stroke. QJM. 2002 Oct;95(10):685–90.CrossRefGoogle ScholarPubMed
22. Ullegaddi, R. et al. Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial. JPEN J Parenter Enteral Nutr. 2006 Mar-Apr;30(2):108–14.CrossRefGoogle ScholarPubMed
23. Polidori, MC. et al. Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study. Biofactors. 2005;24(1–4):265–74.CrossRefGoogle ScholarPubMed
24. Nagata, C. et al. Sodium intake and risk of death from stroke in Japanese men and women. Stroke. 2004 Jul;35(7):1543–7.CrossRefGoogle ScholarPubMed
25. He, J. et al. Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults. JAMA. 1999 Dec 1;282(21):2027–34.CrossRefGoogle ScholarPubMed
26. Green, DM. et al. Serum potassium level and dietary potassium intake as risk factors for stroke. Neurology. 2002 Aug 13;59(3):314–20.CrossRefGoogle ScholarPubMed
27. Bazzano, LA. et al. Dietary potassium intake and risk of stroke in US men and women: National Health and Nutrition Examination Survey I epidemiologic follow-up study. Stroke. 2001 Jul;32(7):1473–80.CrossRefGoogle ScholarPubMed
28. Khaw, KT. et al. Dietary potassium and stroke-associated mortality. A 12-year prospective population study. N Engl J Med. 1987 Jan 29;316(5):235–40.CrossRefGoogle ScholarPubMed
29. Ohira, T. et al. Serum and dietary magnesium and risk of ischemic stroke: the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2009 Jun 15;169(12):1437–44.CrossRefGoogle ScholarPubMed
30. Ascherio, A. et al. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation. 1998 Sep 22;98(12):1198–204.CrossRefGoogle ScholarPubMed
31. Iso, H. et al. Prospective study of calcium, potassium, and magnesium intake and risk of stroke in women. Stroke. 1999 Sep;30(9):1772–9.CrossRefGoogle ScholarPubMed
32. Alderman, MH. Evidence relating dietary sodium to cardiovascular disease. J Am Coll Nutr. 2006 Jun;25(3 Suppl):256S–261S.CrossRefGoogle ScholarPubMed
33. McCarty, MF. Should we restrict chloride rather than sodium? Med Hypotheses. 2004;63(1):138–48.CrossRefGoogle ScholarPubMed
34. Feldstein, CA. Salt intake, hypertension and diabetes mellitus. J Hum Hypertens. 2002 Mar;16 Suppl 1:S48–51.CrossRefGoogle ScholarPubMed
35. Perry, IJ. et al. Salt intake and stroke: a possible direct effect. J Hum Hypertens. 1992 Feb;6(1):23–5.Google ScholarPubMed
36. Cappuccio, FP. et al. Double-blind randomised trial of modest salt restriction in older people. Lancet. 1997 Sep 20;350(9081):850–4.CrossRefGoogle ScholarPubMed
37. MacMahon, S. et al. Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet. 1990 Mar 31;335(8692):765–74.CrossRefGoogle ScholarPubMed
38. Yamori, Y. Experimental evidence for dietary prevention of cardiovascular diseases. Clin Exp Pharmacol Physiol. 1989 Apr;16(4):303–7.CrossRefGoogle ScholarPubMed
39. Heagerty, AM. Salt restriction, a sceptic's viewpoint. Klin Wochenschr. 1991;69 Suppl 25:26–9.Google ScholarPubMed
40. Yamori, Y. et al. Community-based prevention of stroke: nutritional improvement in Japan. Health Rep. 1994;6(1):181–8.Google ScholarPubMed
41. Bray, GA. et al. A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial. Am J Cardiol. 2004 Jul 15;94(2):222–7.CrossRefGoogle ScholarPubMed
42. Fung, TT. et al. Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch Intern Med. 2008 Apr 14;168(7):713–20.CrossRefGoogle ScholarPubMed
43. Umesawa, M. et al. Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: the JPHC Study Cohort I. Stroke. 2008 Sep;39(9):2449–56.CrossRefGoogle ScholarPubMed
44. Abbott, RD. et al. Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men. The Honolulu Heart Program. Stroke. 1996 May;27(5):813–8.CrossRefGoogle ScholarPubMed
45. van der Pols, JC. et al. Childhood dairy and calcium intake and cardiovascular mortality in adulthood: 65-year follow-up of the Boyd Orr cohort. Heart. 2009 Oct;95(19):1600–6.CrossRefGoogle ScholarPubMed
46. Warensjö, E. et al. Stroke and plasma markers of milk fat intake--a prospective nested case-control study. Nutr J. 2009 May 21;8:21.CrossRefGoogle ScholarPubMed
47. Larsson, SC. et al. Dairy foods and risk of stroke. Epidemiology. 2009 May;20(3):355–60.CrossRefGoogle ScholarPubMed
48. Pilz, S. et al. Low vitamin d levels predict stroke in patients referred to coronary angiography. Stroke. 2008 Sep;39(9):2611–3.CrossRefGoogle ScholarPubMed
49. Marniemi, J. et al. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Nutr Metab Cardiovasc Dis. 2005 Jun;15(3):188–97.CrossRefGoogle ScholarPubMed
50. Reis, JP. et al. Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis. Atherosclerosis. 2009 Dec;207(2):585–90.CrossRefGoogle ScholarPubMed
51. Michos, ED. et al. Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7–12.CrossRefGoogle ScholarPubMed
52. Wang, L. et al. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. 2010 Mar 2;152(5):315–23.CrossRefGoogle ScholarPubMed
53. LaCroix, AZ. et al. Calcium plus vitamin D supplementation and mortality in postmenopausal women: the Women's Health Initiative calcium-vitamin D randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2009 May;64(5):559–67.CrossRefGoogle ScholarPubMed
54. He, K. et al. The puzzle of dietary fat intake and risk of ischemic stroke: a brief review of epidemiologic data. J Am Diet Assoc. 2007 Feb;107(2):287–95.CrossRefGoogle ScholarPubMed
55. Boden-Albala, B. et al. Dietary total fat intake and ischemic stroke risk: the Northern Manhattan Study. Neuroepidemiology. 2009;32(4):296–301.CrossRefGoogle ScholarPubMed
56. He, K. et al. Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study. BMJ. 2003 Oct 4;327(7418):777–82.CrossRefGoogle ScholarPubMed
57. Paciaroni, M. et al. Statins and stroke prevention. Expert Rev Cardiovasc Ther. 2009 Oct;7(10):1231–43.CrossRefGoogle ScholarPubMed
58. Spence, JD. Nutrition and stroke prevention. Stroke. 2006 Sep;37(9):2430–5.Google ScholarPubMed
59. Castilla Guerra, L. et al. Statins in stroke prevention: what an internist should know. Eur J Intern Med. 2008 Jan;19(1):8–14.CrossRefGoogle ScholarPubMed
60. Park, Y. et al. Low level of n-3 polyunsaturated fatty acids in erythrocytes is a risk factor for both acute ischemic and hemorrhagic stroke in Koreans. Nutr Res. 2009 Dec;29(12):825–30.CrossRefGoogle ScholarPubMed
61. Bouzan, C. et al. A quantitative analysis of fish consumption and stroke risk. Am J Prev Med. 2005 Nov;29(4):347–52.CrossRefGoogle ScholarPubMed
62. Mozaffarian, D. et al. Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. Arch Intern Med. 2005 Jan 24;165(2):200–6.CrossRefGoogle ScholarPubMed
63. He, K. et al. Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke. 2004 Jul;35(7):1538–42.CrossRefGoogle ScholarPubMed
64. Yamagishi, K. et al. Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. J Am Coll Cardiol. 2008 Sep 16;52(12):988–96.CrossRefGoogle Scholar
65. Wennberg, M. et al. Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. Br J Nutr. 2007 Nov;98(5):1038–45.CrossRefGoogle ScholarPubMed
66. Bravata, DM. et al. Dietary fish or seafood consumption is not related to cerebrovascular disease risk in twin veterans. Neuroepidemiology. 2007;28(3):186–90.CrossRefGoogle Scholar
67. Iso, H. et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA. 2001 Jan 17;285(3):304–12.CrossRefGoogle ScholarPubMed
68. Tanaka, K. et al. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial. Stroke. 2008 Jul;39(7):2052–8.CrossRefGoogle ScholarPubMed
69. Marchioli, R. et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002 Apr 23;105(16):1897–903.CrossRefGoogle ScholarPubMed
70. Burr, ML. Secondary prevention of CHD in UK men: the Diet and Reinfarction Trial and its sequel. Proc Nutr Soc. 2007 Feb;66(1):9–15.CrossRefGoogle ScholarPubMed
71. He, FJ. et al. Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet. 2006 Jan 28;367(9507):320–6.CrossRefGoogle ScholarPubMed
72. Dauchet, L. et al. Fruit and vegetable consumption and risk of stroke: a meta-analysis of cohort studies. Neurology. 2005 Oct 25;65(8):1193–7.CrossRefGoogle ScholarPubMed
73. Mizrahi, A. et al. Plant foods and the risk of cerebrovascular diseases: a potential protection of fruit consumption. Br J Nutr. 2009 Oct;102(7):1075–83.CrossRefGoogle ScholarPubMed
74. Larsson, SC. et al. Dietary fiber and fiber-rich food intake in relation to risk of stroke in male smokers. Eur J Clin Nutr. 2009 Aug;63(8):1016–24.CrossRefGoogle ScholarPubMed
75. Oh, K. et al. Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in women. Am J Epidemiol. 2005 Jan 15;161(2):161–9.CrossRefGoogle ScholarPubMed
76. Flight, I. et al. Cereal grains and legumes in the prevention of coronary heart disease and stroke: a review of the literature. Eur J Clin Nutr. 2006 Oct;60(10):1145–59.CrossRefGoogle ScholarPubMed
77. Kaushik, S. et al. Glycemic index, retinal vascular caliber, and stroke mortality. Stroke. 2009 Jan;40(1):206–12.CrossRefGoogle ScholarPubMed
78. Fung, TT. et al. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation. 2009 Mar 3;119(8):1093–100.CrossRefGoogle ScholarPubMed
79. Karsito, . et al. Diabetes and stroke. Acta Med Indones. 2008 Jul;40(3):151–8.Google ScholarPubMed
80. Chen, YY. et al. [Impact of metabolic syndrome with hyperglycemia on prevalence of stroke in Chinese] Zhonghua Yi Xue Za Zhi. 2009 Feb 17;89(6):385–8.Google ScholarPubMed
81. Yi, SW. et al. Body mass index and stroke mortality by smoking and age at menopause among Korean postmenopausal women. Stroke. 2009 Nov;40(11):3428–35.CrossRefGoogle ScholarPubMed
82. Towfighi, A. et al. The impact of body mass index on mortality after stroke. Stroke. 2009 Aug;40(8):2704–8.CrossRefGoogle ScholarPubMed
83. de Lorgeril, M. et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999 Feb 16;99(6):779–85.CrossRefGoogle ScholarPubMed
84. Tuttle, KR. et al. Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial). Am J Cardiol. 2008 Jun 1;101(11):1523–30.CrossRefGoogle ScholarPubMed
85. Singh, RB. et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet. 2002 Nov 9;360(9344):1455–61.CrossRefGoogle ScholarPubMed
86. Pineo, CE. et al. Cardiovascular benefits of the Mediterranean diet. Nutr Today 2008 May;43(3):114–20.CrossRefGoogle Scholar
87. Howard, BV. et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006 Feb 8;295(6):655–66.CrossRefGoogle ScholarPubMed
88. Liang, W. et al. Tea consumption and ischemic stroke risk: a case-control study in southern China. Stroke. 2009 Jul;40(7):2480–5.CrossRefGoogle Scholar
89. Lopez-Garcia, E. et al. Coffee consumption and risk of stroke in women. Circulation. 2009 Mar 3;119(8):1116–23.CrossRefGoogle ScholarPubMed
90. Larsson, SC. et al. Coffee and tea consumption and risk of stroke subtypes in male smokers. Stroke. 2008 Jun;39(6):1681–7.CrossRefGoogle ScholarPubMed
91. Liang, W. et al. Tea drinking, diet and ischemic stroke prevention in China: a future perspective. Expert Rev Cardiovasc Ther. 2009 Nov;7(11):1447–54.CrossRefGoogle Scholar
92. Liang, W. et al. Soy consumption reduces risk of ischemic stroke: a case-control study in southern china. Neuroepidemiology. 2009;33(2):111–6.CrossRefGoogle ScholarPubMed
93. Kokubo, Y. et al. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation. 2007 Nov 27;116(22):2553–62.CrossRefGoogle ScholarPubMed
94. Klatsky, AL. Alcohol and cardiovascular health. Physiol Behav. 2010 Apr 26;100(1):76–81.CrossRefGoogle ScholarPubMed
95. Reynolds, K. et al. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003 Feb 5;289(5):579–88.CrossRefGoogle ScholarPubMed
96. Mark, SD. et al. Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: the Linxian Nutrition Intervention Trial. Am J Epidemiol. 1996 Apr 1;143(7):658–64.CrossRefGoogle ScholarPubMed
97. Gariballa, SE. Nutritional factors in stroke. Br J Nutr. 2000 Jul;84(1):5–17.CrossRefGoogle ScholarPubMed
98. Willett, WC. The Mediterranean diet: science and practice. Public Health Nutr. 2006 Feb;9(1A):105–10.CrossRefGoogle ScholarPubMed
99. Campbell, NR. et al. Stroke prevention and sodium restriction. Can J Neurol Sci. 2008 Jul;35(3):278–9.CrossRefGoogle ScholarPubMed
100. Cutler, JA. et al. Randomized trials of sodium reduction: an overview. Am J Clin Nutr. 1997 Feb;65(2 Suppl):643S–651S.CrossRefGoogle ScholarPubMed