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Does calmodulin play a functional role in phototransduction?

Published online by Cambridge University Press:  04 February 2010

Mark P. Gray-Keller and
Peter B. Detwiler
Mark P. Gray-Keller
Affiliation:
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195. mgkeller@u.washington.edu
Peter B. Detwiler
Affiliation:
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195. detwiler@ii.washington.edu
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Abstract

Molday and Hsu review results from in vitro experiments, which indicate that Ca-bound calmodulin reduces the cGMP sensitivity of the cyclic nucleotide-gated channel of photoreceptor cells, and speculate about the role they might play in the recovery of the light response. We discuss results from in vivo experiments that argue against the participation of Ca-calmodulin in photorecovery.

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Article Commentary
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Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995, pp. 475 - 476
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Copyright © Cambridge University Press 1995

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