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Principles of brain tissue engineering

Published online by Cambridge University Press:  04 February 2010

William J. Freed  and
Thressa D. Smith
William J. Freed
Affiliation:
Neuropsychiatry Branch
Thressa D. Smith
Affiliation:
Clinical Brain Disorders Branch, National Institute of Mental Health Neuroscience Center at St. Elizabeths, Washington, DC 20032. freed@am.nlmh.nih.gov
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Abstract

It is often presumed that effects of neural tissue transplants are due to release of neurotransmitter. In many cases, however, effects attributed to transplants may be related to phenomena such as trophic effects mediated by glial cells or even tissue reactions to injury. Any conclusion regarding causation of graft effects must be based on the control groups or other comparisons used. In human clinical studies, for example, comparing the same subject before and after transplantation allows for many interpretations of the causes of clinical changes.

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Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 58 - 60
Copyright
Copyright © Cambridge University Press 1995

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