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Sleep and synaptic homeostasis

Published online by Cambridge University Press:  19 July 2005

Giulio Tononi  and
Chiara Cirelli
Giulio Tononi*
Affiliation:
Department of Psychiatry, University of Wisconsin, Madison, WI 53719
Chiara Cirelli*
Affiliation:
Department of Psychiatry, University of Wisconsin, Madison, WI 53719
*
gtononi@wisc.edu
ccirelli@wisc.edu
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Abstract

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We propose that sleep is linked to synaptic homeostasis. Specifically, we propose that: (1) Wakefulness is associated with synaptic potentiation in cortical circuits; (2) synaptic potentiation is tied to the homeostatic regulation of slow wave activity; (3) slow wave activity is associated with synaptic downscaling; and (4) synaptic downscaling is tied to several beneficial effects of sleep, including performance enhancement.

Information

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 28 , Issue 1 , February 2005 , pp. 85
Copyright
Copyright © Cambridge University Press 2005