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Transplantation, plasticity, and the aging host
Published online by Cambridge University Press: 04 February 2010
Abstract
Neural transplantation as a recovery strategy for neuro-degenerative diseases in humans has used mainly grafting following acute denervation strategies in young adult hosts. Our work in aged mice and rats demonstrates an age-related increase in susceptibility to oxidative damage from neurotoxins, a remarkably poor recovery of C57BL/6 mice from MPTP insult with transplantation and growth factors, even at 12 months of age, and diminished plasticity of host neurons. We believe that extrapolation of data from young adult animal models to aged humans without thorough investigation of transplantation and host response in aged recipients is scientifically and ethically inappropriate.
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