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Which cerebellar cells contribute to extracellular cGMP?

Published online by Cambridge University Press:  19 May 2011

Lech Kiedrowski
Affiliation:
The Psychiatric Institute, the University of Illinois at Chicago, Chicago, IL 60612. kied@iris.rfmh.org

Abstract

Vincent proposes that the extracellular cGMP found in cerebellum after glutamate receptor activation is released mainly from Purkinje cells because in these neurons the presence of guanylate cyclase has been shown using monoclonal antibodies. It is uncertain, however, whether Purkinje cells are the only source of extracellular cGMP in the cerebellum. This commentary examines the possibility that glial and cerebellar granule cells may also participate in cGMP synthesis and release, Moreover, the hypothesis of transcellular metabolism of citrulline and arginine is discussed. [VINCENT]

Information

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 1996

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