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Genetics of Panic Disorder

Published online by Cambridge University Press:  07 November 2014

Donatella Marazziti and
Alessandro Rotondo
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Abstract

Systematic studies on the genetics of panic disorder as a distinct nosologic entity separate from anxiety disorders date back to the 1980s. It is, therefore, a relatively new topic for psychiatric genetic investigation. For this reason, available data are not numerous, but findings ensuing from “classical” methods, such as family and twin studies, suggest the involvement of genetic mechanisms to a broad extent, confirmed by the most recent studies. The approaches of molecular genetics, particularly linkage analyses and association studies exploring candidate genes, have led to inconclusive results but have also provided interesting findings that need to be tested in future research.

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Type
Feature Articles
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CNS Spectrums , Volume 4 , Issue 6: Molecular Genetics: Part Two , June 1999, pp. 62 - 70
Copyright
Copyright © Cambridge University Press 1999

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References

REFERENCES

1.Cohen, ME, Badal, DW, Kilpatrick, A, Reed, EW, White, PD. The high familial prevalence of neurocirculatory asthenia (anxiety neurosis, effort syndrome). Am J Hum Genet. 1951;3:126–158.Google ScholarPubMed
2.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. Washington, DC: American Psychiatric Association; 1980.Google Scholar
3.McInnes, RG. Observations on heredity in neurosis. Proc R Soc Med. 1937;30:895–904.Google ScholarPubMed
4.Wood, P. Aetiology of Da Costa's syndrome. Br Med J. 1941;1:841–845.CrossRefGoogle ScholarPubMed
5.Wheeler, ED, White, PD, Reed, E, Cohen, ME. Familial incidence of neurocirculatory asthenia (anxiety neurosis, effort syndrome). J Clin Invest. 1948;27:562–573.Google ScholarPubMed
6.Pauls, DL, Noyes, R Jr, Crowe, RR. The familial prevalence in second degree relatives of patients with anxiety neurosis (panic disorder). J Affect Disord. 1979;1:279–285.CrossRefGoogle ScholarPubMed
7.Crowe, RR, Noyes, R, Pauls, DL, Slymen, D. A family study of panic disorder. Arch Gen Psychiatry. 1983;40:1065–1069.CrossRefGoogle ScholarPubMed
8.Moran, C, Andrews, G. The familial occurrence of agoraphobia. Br J Psychiatry. 1985;146:262–267.CrossRefGoogle ScholarPubMed
9.Noyes, R Jr, Crowe, RR, Harris, EL, Hamra, B, McChesney, CM, Chaudry, DR. Relationship between panic disorder and agoraphobia: a family study. Arch Gen Psychiatry. 1986;43:227–232.CrossRefGoogle ScholarPubMed
10.Crowe, RR. Panic disorder: genetic consideration. J Psychiatr Res. 1990;24:129–134.CrossRefGoogle Scholar
11.Harris, EL, Noyes, R Jr, Crowe, RR, Chaudhry, DR. Family study of agoraphobia: report of a pilot study. Arch Gen Psychiatry. 1983;40:1061–1064.CrossRefGoogle ScholarPubMed
12.Fyer, AJ, Mannuzza, S, Chapman, TF, Martin, LY, Klein, DF. Specificity in familial aggregation of phobic disorders. Arch Gen Psychiatry. 1995;52:564–573.CrossRefGoogle ScholarPubMed
13.Woodman, CL. The genetics of panic disorder and generalized anxiety disorder. Ann Clin Psychiatry. 1993;5:231–240.CrossRefGoogle ScholarPubMed
14.Robins, LN, Helzer, JE, Weissman, MM, et al.Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry. 1984;41:494–498.CrossRefGoogle ScholarPubMed
15.Weissman, MM. Family genetic studies of panic disorder. J Psychiatr Res. 1993;27:69–78.CrossRefGoogle ScholarPubMed
16.Wickramaratne, P, Weissman, M. Using family studies to understand comorbidity. Eur Arch Psychiatry Clin Neurosci. 1993;243:150–157.CrossRefGoogle ScholarPubMed
17.Biederman, J, Rosenbaum, J, Bolduc, F, Faraone, S, Hirshfeld, D. A high risk study of young children of parents with panic disorder and agoraphobia with and without comorbid major depression. Psychiatry Res. 1991;37:333–348.CrossRefGoogle ScholarPubMed
18.Goldstein, RB, Weissman, MM, Adams, PB, et al.Psychiatric disorders in relatives of probands with panic disorder and/or major depression. Arch Gen Psychiatry. 1994;51:383–394.CrossRefGoogle ScholarPubMed
19.Maier, W, Minges, J, Lichtermann, D. The familial relationship between panic disorder and unipolar depression. J Pychiatr Res. 1995;29:375–388.CrossRefGoogle ScholarPubMed
20.Blacker, D, Lavori, P, Faraone, S, Tsuang, M. Unipolar relatives in bipolar pedigrees: a search for indicators of underlying bipolarity. Am J Med Genet. 1993;48:192–199.CrossRefGoogle ScholarPubMed
21.Torgersen, S. Comorbidity of major depression and anxiety disorders in twin pairs. Am J Psychiatry. 1990;147:1199–1202.Google ScholarPubMed
22.Kendler, KS, Heath, AC, Martin, NG, Eaves, LJ. Symptoms of anxiety and symptoms of depression: same genes, different environments? Arch Gen Psychiatry. 1987;44;451–457.CrossRefGoogle ScholarPubMed
23.Kendler, KS, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJ. Major depression and phobias: the genetic and environmental sources of comorbidity. Psychol Med. 1993;23:361–371.CrossRefGoogle ScholarPubMed
24.Noyes, R Jr, Clarkson, D, Crowe, RR, Yates, WR, McChesney, CM. A family study of generalized anxiety disorder. Am J Psychiatry. 1987;144:1019–1024.Google ScholarPubMed
25.Fyer, A, Mannuzza, S, Chapman, T, Lipsitz, J, Martin, L, Klein, D. Panic disorder and social phobia: effects of comorbidity on familial transmission. Anxiety. 1996;2:173–178.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
26.Horwath, E, Wolk, SI, Goldstein, RB, et al.Is the comorbidity between social phobia and panic disorder due to familial cotransmission or other factors? Arch Gen Psychiatry. 1995;52:574–582.CrossRefGoogle ScholarPubMed
27.Torgersen, S. Genetic factors in anxiety disorders. Arch Gen Psychiatry. 1983;40:1085–1089.CrossRefGoogle ScholarPubMed
28.Skre, I, Onstad, S, Torgersen, S, Lygren, S, Kringlen, E. A twin study of DSM-III-R anxiety disorders. Acta Psychiatr Scand. 1993;88:85–92.CrossRefGoogle ScholarPubMed
29.Perna, G, Caldirola, D, Arancio, D, Bellodi, L. Panic attacks: a twin study. Psychiatry Res. 1997;66:69–71.CrossRefGoogle ScholarPubMed
30.Andrews, G, Stewart, G, Allen, R, Henderson, A. The genetics of six neurotic disorders: a twin study. J Affect Disord. 1990;19:23–29.CrossRefGoogle ScholarPubMed
31.Smoller, JW, Tsuang, MT. Panic and phobic anxiety: defining phenotypes for genetic studies. Am J Psychiatry. 1998;9:1152–1162.CrossRefGoogle Scholar
32.Klein, DF. Panic and phobic anxiety: phenotypes, endophenotypes, and genotypes. Am J Psychiatry. 1998;155:1147–1149.CrossRefGoogle ScholarPubMed
33.Perna, G, Cocchi, S, Bertani, A, Arancio, C, Bellodi, L. Sensitivity to 35% C02 in healthy first-degree relatives of patients with panic disorder. Am J Psychiatry. 1995;152:623–625.Google Scholar
34.Coryell, WH. Hypersensitivity to carbon dioxide as a disease specific trait marker. Biol Psychiatry. 1997;41:259–263.CrossRefGoogle ScholarPubMed
35.Bellodi, L, Perna, G, Cardirola, D, Arancio, C, Bertani, A, Di Bella, D. C02-induced panic attacks: a twin study. Am J Psychiatry. 1998;155:1184–1188.CrossRefGoogle Scholar
36.Crowe, R, Noyes, R Jr, Wilson, A, Elston, R, Ward, L. A linkage study of panic disorder. Arch Gen Psychiatry. 1987;44:933–937.CrossRefGoogle ScholarPubMed
37.Crowe, RR, Noyes, R Jr, Samuelson, S, Wesner, R, Wilson, R. Close linkage between panic disorder and alpha-hap-toglobin excluded in 10 families. Arch Gen Psychiatry. 1990;47:377–380.CrossRefGoogle ScholarPubMed
38.Knowles, JA, Fyer, AJ, Vieland, VJ, et al.Results of a genome-wide genetic screen for panic disorder. Am J Med Genet. 1998;81:139–147.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
39.Mutchler, K, Crowe, RR, Noyes, R Jr, Wesner, RW. Exclusion of the tyrosine hydroxylase gene in 14 panic disorder pedigrees. Am J Psychiatry. 1990;147:1367–1369.Google ScholarPubMed
40.Wang, ZW, Crowe, RR, Noyes, R Jr. Adrenergic receptor genes as candidate genes for panic disorder: a linkage study. Am J Psychiatry. 1992;149:470–474.Google ScholarPubMed
41.Crowe, RR, Wang, Z, Noyes, R, et al.Candidate gene study of eight GABAA receptor subunits in panic disorder. Am J Psychiatry. 1997;154:1096–1100.Google ScholarPubMed
42.Schmidt, SM, Zoega, T, Crowe, RR. Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. Acta Psychiatr Scand. 1993;88:225–228.CrossRefGoogle ScholarPubMed
43.Crowe, RR, Noyes, R Jr, Persico, AM. Pro-opiome-lanocortin (POMC) gene excluded as a cause of panic disorder in a large family. J Affect Disord. 1987; 12:23–27.CrossRefGoogle Scholar
44.Crawford, F, Hoyne, J, Diaz, P, et al.Occurrence of the Cys311 DRD2 variant in a pedigree multiply affected with panic disorder. Am J Med Genet. 1995;60:332–334.CrossRefGoogle Scholar
45.Heils, A, Teufel, A, Petri, S, et al.Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996;66:2621–2624.CrossRefGoogle ScholarPubMed
46.Deckert, J, Catalano, M, Heils, A, et al.Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet. 1997;7:45–47.CrossRefGoogle ScholarPubMed
47.Ishiguro, H, Armami, T, Yamada, K, Otsuka, Y, Toru, M, Shibuya, H. An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population. Psychiatry Clin Neurosci. 1997;51:333–335.CrossRefGoogle Scholar
48.Matsushita, S, Muramatsu, T, Kimura, M, et al.Serotonin transporter gene regulatory region polymorphism and panic disorder. Mol Psychiatry. 1997;2:390–392.CrossRefGoogle ScholarPubMed
49.Rotondo, A, Mezzanti, CM, Michelini, S, et al.Association study of panic, obsessive-compulsive and eating disorders with a functional polymorphism of the serotonin transporter promoter [abstract]. Eur Neuropsychopharmacol. 1997;7:S236.CrossRefGoogle Scholar
50.Ohara, K, Xie, DW, Ishigaki, T, et al.The genes encoding the 5HT1Dα and 5HT1Dβ receptors are unchanged in patients with panic disorder. Biol Psychiatry. 1996;39:5–10.CrossRefGoogle Scholar
51.Steinlein, OK, Deckert, J, Nothen, MM, et al.Neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) and panic disorder: an association study. Am J Med Genet. 1997;74:199–201.3.0.CO;2-D>CrossRefGoogle ScholarPubMed
52.Deckert, J, Nothen, MM, Franke, P, et al.Systematic mutation screening and association study of the A1 and A2α adenosine receptor genes in panic disorder suggest a contribution of the A2α gene to the development of disease. Mol Psychiatry. 1998;3:81–85.CrossRefGoogle Scholar
53.Bradwein, J, Koszycki, D, Meterissian, G. Cholecystokinin-tetrapeptide induced panic attacks in patients with panic disorder. Can J Psychiatry. 1990;35:83–85.CrossRefGoogle Scholar
54.Kato, T, Wang, ZW, Zoega, T, Crowe, RR. Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder. Am J Med Genet. 1996;67:401–405.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
55.Wang, Z, Valdes, J, Noyes, R, Zoega, T, Crowe, RR. Possible association of a cholecystokinin promotor polymorphism (CCK -36CT) with panic disorder. Am J Med Genet. 1998;81:228–234.3.0.CO;2-S>CrossRefGoogle ScholarPubMed