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Brain-Imaging Studies of Posttraumatic Stress Disorder

Published online by Cambridge University Press:  07 November 2014

Israel Liberzon and
K. Luan Phan
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Abstract

Brain-imaging studies of posttraumatic stress disorder (PTSD) have rapidly increased in recent years. Structural studies have identified potential smaller volumes of the hippocampus of traumatized and/or PTSD subjects. Functional activation studies have implicated hyperactive or altered functioning of brain regions, such as the amygdala and the insula, and a failure to engage emotional regulatory structures, such as the medial prefrontal and anterior cingulate cortex. Recent neurochemical investigations have suggested that neuromodulatory systems (eg, γ-aminobutyric acid, μ-opioid) may underlie these aberrant brain activation patterns. This article reviews the literature on structural, functional, and neurochemical brain-imaging studies of PTSD.

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Type
Review Article
Information
CNS Spectrums , Volume 8 , Issue 9: Posttraumatic Stress Disorder , September 2003, pp. 641 - 650
Copyright
Copyright © Cambridge University Press 2003

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