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The Genetics of Obsessive-Compulsive Disorder: An Immunologic Perspective

Published online by Cambridge University Press:  07 November 2014

Mark Hyman Rapaport and
Cathy G. McAllister
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Abstract

This article presents a rationale for the hypothesis that an autoimmune mechanism might be involved in the pathogenesis of some forms of obsessive-compulsive aborder (OCO). Existing clinical studies suggesting that some individuals with OCD may have an autoimmune-mediated disorder are briefly summarized. A case example where intravenous immunoglobulin G has been successfully used to treat an adult with OCD spectrum disorder is presented. Preclinical data demonstrating that fragments from the group Αβ hemolytic streptococcus cell wall M proteins can generate antibodies that bind to rat and human tissue are also presented.

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Type
Feature Articles
Information
CNS Spectrums , Volume 4 , Issue 6: Molecular Genetics: Part Two , June 1999, pp. 71 - 77
Copyright
Copyright © Cambridge University Press 1999

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