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Pain Perception in Irritable Bowel Syndrome

Published online by Cambridge University Press:  07 November 2014

Kirsten Tillisch and
Emeran A. Mayer
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Abstract

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by chronic abdominal discomfort or pain in the absence of detectable organic disease. IBS is common and is associated with a significant impairment in health-related quality of life. Enhanced perception of visceral stimuli (“visceral hypersensitivity”) appears to be an important patho-physiological mechanism. Early IBS studies using functional brain imaging techniques suggest an alteration in central pain modulation circuits, rather than an increased sensitivity of peripheral visceral pain pathways. The frequent comorbidity with psychiatric disorders suggests the possibility of shared pathophysiological mechanisms and etiologic factors.

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Type
Review Articles
Information
CNS Spectrums , Volume 10 , Issue 11 , November 2005, pp. 877 - 882
Copyright
Copyright © Cambridge University Press 2005

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