This special issue is devoted to papers from the meeting on Combinatorics and Probability, held at the Mathematisches Forschungsinstitut in Oberwolfach from the 17th to the 23rd April 2016. The lectures at this meeting focused on the common themes of Combinatorics and Discrete Probability, with many of the problems studied originating in Theoretical Computer Science. The lectures, many of which were given by young participants, stimulated fruitful discussions. The fact that the participants work in different and yet related topics, and the open problems session held during the meeting, encouraged interesting discussions and collaborations.