A p-adically uniformized variety is a smooth projective variety whose associated rigid analytic space admits a uniformization by Drinfeld's p-adic symmetric domain. For such a variety we prove the monodromy-weight conjecture, which asserts that two independently defined filtrations on the log-crystalline cohomology of the special fiber in fact coincide. The proof proceeds by reducing the conjecture to a combinatorial statement about harmonic cochains on the Bruhat–Tits building, which was verified in our previous work.