The focus of this article is on the interface between research on resilience—a constructrepresenting positive adaptation despite adversity —and the applications of this work to thedevelopment of interventions and social policies. Salient defining features of research on resilienceare delineated, as are various advantages, limitations, and precautions linked with the applicationof the resilience framework to developing interventions. For future applied efforts within thistradition, a series of guiding principles are presented along with exemplars of existing programsbased on the resilience paradigm. The article concludes with discussions of directions for futurework in this area, with emphases on an enhanced interface between science and practice, and abroadened scope of resilience-based interventions in terms of the types of populations, and thetypes of adjustment domains, that are encompassed.