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Experimental observations on the pathogenesis of necrobacillosis

Published online by Cambridge University Press:  15 May 2009

G. R. Smith,
L. M. Wallace and
D. E. Noakes
G. R. Smith
Affiliation:
Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY, UK.
L. M. Wallace
Affiliation:
Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY, UK.
D. E. Noakes
Affiliation:
Department of Surgery and Obstetrics, Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, UK.
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Summary

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Earlier studies showed that the minimum infective dose (>106 organisms) of a virulent strain of Fusobacterium necrophorum could be greatly reduced by suspending the fusobacteria in sub-lethal doses of cultures of other bacteria such as Escherichia coli before inoculating mice subcutaneously.

In the present study the infective dose of the same strain of F. necrophorum was reduced by a factor of >103 by suspending the fusobacteria in sub-lethal doses of 5% homogenate of gaur or wallaby faeces. Sterile faecal filtrate had no such effect. The sites of low grade infection produced by the prior subcutaneous injection of E. coli culture or gaur faecal suspension were susceptible to superinfection by doses of F. necrophorum far below those required to infect normal tissue.

This work helps to explain the production of necrobacillosis by the faecal contamination of small wounds. It proved impossible, however, to produce necrobacillosis in mice by the subcutaneous injection of faecal suspensions from 33 farm cattle. This suggests that the proportion of cattle with virulent F. necrophorum in their faeces is low.

Information

Type
Research Article
Information
Epidemiology & Infection , Volume 104 , Issue 1 , February 1990, pp. 73 - 78
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

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