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The status of CMV as a human pathogen

Published online by Cambridge University Press:  19 October 2009

P. D. Griffiths and
J. E. Grundy
P. D. Griffiths
Affiliation:
Department of Virology, Royal Free Hospital School of Medicine, London NW3, England
J. E. Grundy
Affiliation:
Department of Virology, Royal Free Hospital School of Medicine, London NW3, England
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Abstract

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Cytomegalovirus (CMV) is a common infectious agent which is well adapted to its host. Following primary infection, which is almost always asymptomatic in people with normal immunity, the virus establishes latency at sites which are unknown. The virus is probably maintained in this latent state by immune surveillance mechanisms since immunosuppression frequently leads to reactivation of virus.

Cytomegalovirus has been identified in most anatomical areas of the human body. The aim of this article is to define criteria for pathogenicity so that clinical and experimental data can be reviewed to determine if CMV is likely to cause disease at these various clinical sites. Thus, patients have been shown to die frequently with CMV but do they die from it?

Information

Type
Special Article
Information
Epidemiology & Infection , Volume 100 , Issue 1 , February 1988, pp. 1 - 15
Copyright
Copyright © Cambridge University Press 1988

References

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