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Bleeding induced by SSRIs

Published online by Cambridge University Press:  16 April 2020

M.E. Ceylan and
M.H. Alpsan-Omay
M.E. Ceylan*
Affiliation:
Bakirkoy Mental Hospital, Incirli Cad. 88/3 Bakirkoy, Istanbul, Turkey
M.H. Alpsan-Omay
Affiliation:
Psychiatry Department, Clinical Neuroscience Research Unit, Connecticut Mental Health Center, Yale University, New Haven, USA
*
*Corresponding author. E-mail address:meceylan@superonline.com (M.E. Ceylan).
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Abstract

Selective Serotonin Reuptake Inhibitors (SSRIs) have been accused of causing bleeding problems as a side effect. Theories about the mechanism are still being discussed. We report a case, presenting bleeding problems, during sertraline treatment. The SSRIs are widely used to treat depression and many other psychiatric disorders. Their lower severity of side effects and being markedly safer in overdose are some of the reasons of their preference as primary choice in most of the cases. Besides their common side effects like, agitation, headache, insomnia, weight gain or loss, and sexual dysfunction, SSRIs also have been suspected of increasing the risk of bleeding. A population-based cohort study supported the hypothesis of an increased risk of upper gastrointestinal bleeding during the use of SSRIs, and they also indicated that this effect is potentiated with concurrent use of NSAIDs or low-dose aspirin. We would like to report our recent experience with one patient who was on sertraline, 50mg/day.

Keywords

SSRIsBleedingComplications

Information

Type
Case report
Information
European Psychiatry , Volume 20 , Issue 8 , December 2005, pp. 570 - 571
Copyright
Copyright © Elsevier SAS 2005

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References

Aranth, JLindberg, CBleeding, a side effect of fluoxetine. Am J Psychiatry 1992; 149(3):412[letter]Google ScholarPubMed
Calhoun, JWCalhoun, DDProlonged bleeding time in a patient treated with sertraline. Am J Psychiatry 1996;153(3):443[letter]Google Scholar
Dalton, SOJohansen, CMellemkjaer, LNorgard, BSorensen, HTOlsen, JHUse of selective reuptake inhibitors and risk of upper gastrointestinal tract bleeding. Arch Intern Med 2003;163 13:59–64.CrossRefGoogle ScholarPubMed
De Clerk, FFHerman, AG5-hydroxyryptamine and platelet aggregation. Fed Proc 1983;42:228–232.Google Scholar
Li, NWallen, NHLadjevardi, MHjemdahl, PEffects of serotonin on platelet activation in whole blood. Blood Coagul Fibrinolysis 1997;8:517–523.CrossRefGoogle ScholarPubMed
Maurer-Spurej, EPittendreigh, CSolomons, KThe influence of selective serotonin reuptake inhibitors on human platelet serotonin. Thromb Haemost 2004;91:119–128.Google ScholarPubMed
Ottervanger, JPStricker, MBWeeda, JNBleeding attributed to the intake of paroxetine. Am J Psychiatry 1994;151(5)[letter]Google ScholarPubMed
Shen, WWConrad, MSCalhoun, JWIs inhibition of nitric oxide synthase a mechanism for SSRI-induced bleeding?. Psychosomatics 1999;40(3):268–269.CrossRefGoogle ScholarPubMed
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