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Estimation of effective population size from data on linkage disequilibrium1

Published online by Cambridge University Press:  14 April 2009

William G. Hill
William G. Hill
Affiliation:
Department of Statistics, North Carolina State University, Raleigh, North Carolina 27650, U.S.A. and Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN2
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Summary

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A method is proposed for estimating effective population size (N) from data on linkage disequilibrium among neutral genes at several polymorphic loci or restriction sites. The efficiency of the method increases with larger sample size and more tightly linked genes; but for very tightly linked genes estimates of N are more dependent on long-term than on recent population history. Two sets of data are analysed as examples.

Information

Type
Research Article
Information
Genetics Research , Volume 38 , Issue 3 , December 1981, pp. 209 - 216
Copyright
Copyright © Cambridge University Press 1981

References

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