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Genomic imprinting: normal complementation of murine chromosome 16

Published online by Cambridge University Press:  14 April 2009

Christoph N. Berger and
Charles J. Epstein
Christoph N. Berger
Affiliation:
Departments of Pediatrics, Box 0548, University of California, San Francisco, California 94143
Charles J. Epstein
Affiliation:
Departments of Pediatrics, Box 0548, University of California, San Francisco, California 94143Departments of Biochemistry and Biophysics, Box 0548, University of California, San Francisco, California 94143
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Parental imprinting effects for chromosome 16 were investigated using disomic animals which were obtained by mating (Rb32Lub × Rb2H) F1 mice. Two allelic forms of the enzyme CuZn-superoxide dismutase, Sod-1a and Sod-1c, were` used to identify maternally or paternally disomic animals. Both types of disomic animals were found with the expected frequencies and did not visibly differ from one another or from non-disomic animals. These results indicate that the genomic imprinting mechanism either does not act on chromosome 16, or, if it does, does not do so in a manner which affects normal development.

Information

Type
Research Article
Information
Genetics Research , Volume 54 , Issue 3 , December 1989, pp. 227 - 230
Copyright
Copyright © Cambridge University Press 1989

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