Hostname: page-component-74656f9884-2dmjx Total loading time: 0 Render date: 2026-11-09T13:18:31.370Z Has data issue: false hasContentIssue false
  • English
  • Français

Mapping an invisible lethal in the mouse

Published online by Cambridge University Press:  14 April 2009

Margaret E. Wallace
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

An effective breeding policy is described for detecting linkage in the mouse, for an ante-natal lethal from crosses of heterozygotes with stocks homozygous for several linked recessive markers. A method of analysing the ensuing data is described, together with a method of estimating the map distance to close markers. A practical illustration is described, involving an ante-natal lethal obtained from a colony of wild mice and a four fold recessive chromosome 2 marker stock.

Information

Type
Research Article
Information
Genetics Research , Volume 27 , Issue 1 , February 1976 , pp. 3 - 10
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Fisher, R. A. & Landauer, W. (1953). Sex differences of crossing-over in close linkage. American Naturalist 87, 116.CrossRefGoogle Scholar
Green, M. C. (1974). Linkage Map of the Mouse. Mouse News Letter 51, 7.Google Scholar
Gruneberg, H. (1953). Genetical studies on the skeleton of the mouse. VII. Congenital hydrocephalus. Journal of Genetics 51, 327–358.CrossRefGoogle Scholar
Mather, K. (1963). The Measurement of Linkage in Heredity, 2nd edn.London: Methuen.Google Scholar
Meredith, R. (1964 a) Mouse News Letter 31, 25.Google Scholar
Meredith, R. (1964 b). Detection and care of mouse mutants. Journal of Animal Technicians Association 15, 22–27.Google Scholar
Robinson, R. (1972). Gene Mapping in Laboratory Mammals, Part B, pp. 358–359. London and New York: Plenum Press.Google Scholar
Robinson, R. (1972). Gene Mapping in Laboratory Mammals, Part A, p. 14. London and New York: Plenum Press.Google Scholar
Russell, L. B., McDaniel, M. N. C. & Woodiel, F. N. (1963). Crossing-over within the ‘a’ locus of the mouse. Genetics 48, 907.Google Scholar
Wallace, M. E. (1971). An unprecedented number of mutants in a colony of wild mice. Environmental Pollution 1, 175–184.Google Scholar
Wallace, M. E. (1972). Reduction in recombination due to a deletion in a wild colony of mice. Journal of Heredity 63, 297–300.CrossRefGoogle Scholar