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Multiple changes in lens protein composition associated with the CatFr gene in the mouse

Published online by Cambridge University Press:  14 April 2009

T. H. Day and
R. M. Clayton
T. H. Day
Affiliation:
Institute of Animal Genetics, Edinburgh University, and Genetics Laboratory, University of Nottingham
R. M. Clayton
Affiliation:
Institute of Animal Genetics, Edinburgh University
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Summary

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The ocular cataracts produced by the dominant CatFr gene in the mouse, Mus musculus, are associated with quantitative changes in the lens proteins (crystallins). The three classes of crystallin are affected differentially in homozygotes. Heterozygotes show a smaller effect. The quantitative levels of crystallin subunits are also affected and these changes are different for each subunit. The overall loss in protein is not readily explicable hi terms of a generalised leakage or a general tendency to insolubilisation. Possible mechanisms for the action of the gene are suggested.

Information

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 3 , June 1972, pp. 241 - 249
Copyright
Copyright © Cambridge University Press 1972

References

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