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Selection against harmful mutations in large sexual and asexual populations

Published online by Cambridge University Press:  14 April 2009

Alexey S. Kondrashov
Alexey S. Kondrashov
Affiliation:
Research Computer Centre of the Academy of Sciences of the USSR, Pushchino, Moscow Region, 142292, USSR
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Selection against harmful mutations in large populations is studied assuming that the rate of fitness decrease grows with every new mutation added to a genome. Under this reasonable assumption (Mayr, 1970) the average fitness of a sexual population, without linkage between the loci, is higher, and the average equilibrium number of harmful mutations per individual lower, than in an asexual population. If a gamete contains on the average one or more new mutations, the resulting advantage of sexual reproduction and recombination seems to be sufficient to counterbalance the double advantage of parthenogenesis. Moreover, selection against harmful mutations is probably the most powerful factor preventing linkage disequilibrium even with epistatic interaction between the loci.

Information

Type
Short Paper
Information
Genetics Research , Volume 40 , Issue 3 , December 1982, pp. 325 - 332
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Clegg, M. T., Kidwell, J. F. & Horch, C. R. (1980). Dynamics of correlated genetic systems. V. Rates of decay of linkage disequilibria in experimental population of Drosophila melanogaster. Genetics 94, 217–234.CrossRefGoogle ScholarPubMed
Feldman, M. W., Christiansen, F. B. & Brooks, L. D. (1980). Evolution of recombination in constant environment. Proceedings of the National Academy of Sciences of the USA 77, 4838–4841.CrossRefGoogle ScholarPubMed
Kimura, M. & Crow, J. F. (1979). Efficiency of truncation selection. Proceedings of the National Academy of Sciences of the USA 76, 396–399.Google Scholar
Leslie, J. F. & Vrijenhoek, R. C. (1978). Genetic dissection of clonally inherited genomes of Poecilopsis. I. Linkage analysis and preliminary assessment of deleterious gene loads. Genetics 90, 801–811.CrossRefGoogle ScholarPubMed
Li, W.-H., Gojobori, T. & Nei, M. (1981). Pseudogenes as a paradigm of neutral evolution. Nature 292, 8237–8239.CrossRefGoogle ScholarPubMed
Loukas, M., Vegrini, Y. & Krimbas, C. B. (1981). The genetics of Drosophila subobscura populations. XVII. Further genie heterogeneity within electromorphs by urea denaturation and the effect of the increased genie variability on linkage disequilibrium studies. Genetics 97, 429–441.CrossRefGoogle Scholar
Maynard Smith, J. (1978). The Evolution of Sex. Cambridge University Press.Google Scholar
Maynard Smith, J. (1980). Selection for recombination in a polygenic model. Genetical Research 35, 269–278.CrossRefGoogle Scholar
Mayr, E. (1970). Populations, species and evolution. Harvard University Press, Cambridge, Mass.Google Scholar
Mukai, T., Chigusa, S. T., Mettler, L. E. & Crow, J. F. (1972). Mutation rate and dominance of genes affecting viability in Drosophila melanogaster. Genetics 72, 335–355.CrossRefGoogle ScholarPubMed
Muller, H. J. (1964). The relation of recombination to mutational advance. Mutation Research 1, 2–9.CrossRefGoogle Scholar