Hostname: page-component-7b7567c8c-7pwfn Total loading time: 0 Render date: 2026-11-12T10:13:02.545Z Has data issue: false hasContentIssue false
  • English
  • Français

Selection for recombination in a polygenic model – the mechanism

Published online by Cambridge University Press:  14 April 2009

J. Maynard Smith
J. Maynard Smith
Affiliation:
School of Biological Sciences, University of Sussex, Brighton BN1 9QG
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

A polygenic model has been simulated in order to reveal the process whereby selection in an infinite population can lead to an increase in the frequency of alleles causing higher rates of recombination (CH alleles). Directional selection generates repulsion linkage disequilibrium (+ − + −), which is less strong in CH gametes (gametes carrying CH alleles). In consequence, CH gametes contribute greater phenotypic variability, and therefore respond more to directional selection: that is, they accumulate more selectively favoured alleles. CH alleles then increase in frequency by hitch-hiking. In contrast, normalizing selection, or frequent changes in the direction of selection, favour alleles for a low recombination rate.

Information

Type
Research Article
Information
Genetics Research , Volume 51 , Issue 1 , February 1988, pp. 59 - 63
Copyright
Copyright © Cambridge University Press 1988

References

Bell, G. & Maynard Smith, J. (1987). Short-term selection for recombination among mutually antagonistic species. Nature 327, 66–68.CrossRefGoogle Scholar
Bulmer, M. G. (1980). The Mathematical Theory of Quantitative Genetics. Oxford: Clarendon Press.Google Scholar
Burt, A. & Bell, G. (1987). Mammalian chiasma frequencies as a test of two theories of recombination. Nature 326, 803–805.CrossRefGoogle ScholarPubMed
Charlesworth, B. (1976). Recombination modification in a fluctuating environment. Genetics 83, 181–195.CrossRefGoogle Scholar
Felsenstein, J. (1965). The effect of linkage on directional selection. Genetics 52, 349–363.CrossRefGoogle ScholarPubMed
Fraser, A. S. (1957). Simulation of genetic systems by automatic digital computers. II. Effects of linkage on rates of advance under selection. Australian Journal of Biological Science 10, 492–499.CrossRefGoogle Scholar
Maynard Smith, J. (1980). Selection for recombination in a polygenic model. Genetical Research 35, 269–277.CrossRefGoogle Scholar