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Selective fertilization at the T-locus of the mouse

Published online by Cambridge University Press:  14 April 2009

Nigel Bateman
Nigel Bateman
Affiliation:
Agricultural Research Council's Animal Breeding Research Organisation, Edinburgh 9
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Advantage was taken of a unique situation to test, with adequate controls, the assertion that male and female gametes conjugate at random. The data concern the aberrant locus T of the mouse, at which there are a number of t alleles that enter into the majority of effective spermatozoa of males heterozygous for one of them. Segregation in females is normal. Evidence is presented for one of these t alleles, tailless-Edinburgh (te), that conjugation between gametes was not at random when this gene was present in spermatozoa. When a choice of eggs was presented by heterozygous females, tailless-Edinburgh spermatozoa united more frequently with normal than with brachyury eggs and more frequently with brachyury than with tailless-Edinburgh eggs. The relevance of this finding is discussed in relation to expected equilibria of t alleles in closed populations. Other forms of selective fertilization are discussed and their genetic consequences compared.

Information

Type
Research Article
Information
Genetics Research , Volume 1 , Issue 2 , July 1960, pp. 226 - 238
Copyright
Copyright © Cambridge University Press 1960

References

REFERENCES

Bateman, N. (1960). High frequency of a lethal gene (te) in a laboratory stock of mice. Genet. Res. 1, 214–225.CrossRefGoogle Scholar
Beatty, R. A. (1957). Parthenogenesis and polyploidy in mammalian development, p. 2. Cambridge: University Press.Google Scholar
Braden, A. W. H. (1957). Variation between strains of mice in phenomena associated with sperm penetration and fertilization. J. Genet. 56, 1–11.Google Scholar
Braden, A. W. H. (1958). Influence of time of mating on the segregation ratio of alleles at the T locus in the house mouse. Nature Lond. 181, 786–787.CrossRefGoogle Scholar
Braden, A. W. H. & Gluecksohn-Waelsch, S. (1958). Further studies on the effect of the T locus in the house mouse on male fertility. J. exp. Zool. 138, 431–452.CrossRefGoogle Scholar
Bruck, D. (1957). Male segregation ratio advantage as a factor in maintaining lethal alleles in wild populations of house mice. Proc. not. Acad. Sci., Wash. 43, 152–158.CrossRefGoogle ScholarPubMed
Dunn, L. C. (1953). Variations in the segregation ratio as causes of variations in gene frequency. Acta Genet. 4, 148–151.Google Scholar
Dunn, L. C. (1957). Evidence of evolutionary forces leading to the spread of lethal genes in wild populations of house mice. Proc. Nat. Acad. Sci., Wash. 43, 158–163.CrossRefGoogle Scholar
Dunn, L. C., Beasley, A. B. & Tinker, H. (1958). Relative fitness of wild house mice heterozygous for a lethal gene. Amer. Nat. 92, 215–220.CrossRefGoogle Scholar
Dunn, L. C. & Gluecksohn-Waelsch, S. (1953). Genetic analysis of seven newly-discovered mutant alleles at the locus T in the house mouse. Genetics, 38, 261–271.CrossRefGoogle Scholar
Dunn, L. C. & Suckling, J. (1956). Studies of the genetic variability in wild populations of house mice. I. Analysis of seven alleles at locus T. Genetics, 41, 344–352.CrossRefGoogle ScholarPubMed
Grüneberg, H. (1952). The Genetics of the Mouse, 2nd ed., pp. 315–335. The Hague: Martinus Nijhoff.Google Scholar
Lindegren, C. C. & Lindegren, G. (1956). Effect of local chromosome environment upon the genotype. Nature, Land. 178, 796–797.CrossRefGoogle ScholarPubMed
Sandler, I. & Novitski, E. (1957). Meiotic drive as an evolutionary force. Amer. Nat. 91, 105–110.Google Scholar
Sandler, L., Hiraizumi, Y. & Sandler, I. (1959). Meiotic drive in natural populations of Drosophila melanogaster. I. The cytogenetic basis of segregation distortion. Genetics, 44, 233–250.CrossRefGoogle ScholarPubMed
Smith, L. J. (1956). A morphological and histochemical investigation of a preimplantation lethal (t 12) in the house mouse. J. exp. Zool. 132, 51–83.Google Scholar
Wallace, B. (1948). Studies on ‘sex-ratio’ in Drosophila pseudo-obscura. I. Selection and ‘sex-ratio’. Evolution, 2, 189–217.Google Scholar
Weir, J. A. (1958). Sex ratio related to sperm source in mice. J. Hered. 49, 223–227.Google Scholar
White, M. J. D. (1945). Animal Cytology and Evolution, p. 82. Cambridge: University Press.Google Scholar