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XXY Mice

Published online by Cambridge University Press:  14 April 2009

Bruce M. Cattanach
Bruce M. Cattanach
Affiliation:
Medical Research Council Induced Mutagenesis Group, Institute of Animal Genetics, Edinburgh, 9
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Welshons & Russell (1959) have presented data to show that the XO chromosomal constitution in the mouse is female. This conclusion was based on results of genetical tests with sex-linked markers and on chromosome counts. All XO females were matroclinous, that is, they had inherited their X-chromosome from their mother. Females of this type will arise when non-disjunction occurs in the meiotic divisions of the father and results in spermatozoa without a sex-chromosome. Alternatively, the paternal sex-chromosome may be lost from the fertilized ovum if non-disjunction of sister-chromatids occurs during the first cleavage division. This latter explanation has been urged by Ohno, Kaplan & Kinosita (1959), who found no evidence for non-disjunction of the X-and Y-chromosome in an extensive cytolosical examination of the mouse testis.

Information

Type
Short Notes
Information
Genetics Research , Volume 2 , Issue 1 , February 1961 , pp. 156 - 158
Copyright
Copyright © Cambridge University Press 1961

References

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