This article aims to integrate the biblical theological idea of the heart with Alfred North Whitehead's ideas concerning human selfhood. It begins with a biblical theological description of the heart, drawing to a focus upon Ezekiel's idea of God creating in us a new heart. It then interprets these ideas by correlating them with key ideas of Whitehead, such as actual entity, actual occasion, living person, historic route, the four phases of the actual entity, initial aim, and subjective aim. This correlation peaks in the idea that for process anthropology a new heart is created in us every new instant.