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Acyclovir

Published online by Cambridge University Press:  02 January 2015

Cynthia Ann Zabrosky and
Gary Milkovich
Cynthia Ann Zabrosky*
Affiliation:
Department of Pharmacy Services, Alexandria, Virginia
Gary Milkovich
Affiliation:
Department of Pharmacy Services, Alexandria, Virginia
*
Department of Pharmacy Services, 4320 Seminary Road, Alexandria, VA 22304
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Extract

In recent years there have been great advances made in antiviral therapy. One of the most promising of the new agents to be introduced is acyclovir. This antiviral, which selectively inhibits the replication of particular DNA viruses, is being used clinically in the treatment and prevention of viral infections caused by several of the herpes viruses. Though not a cure, acyclovir can be effective for the management of symptoms associated with these infections. Since acyclovir acts only on replicating viral DNA, the drug has no effect on the latent virus which establishes itself in neural tissue. This makes eradication of the virus very difficult.

Information

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 7 , Issue 4 , April 1986, pp. 228 - 229
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1986

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References

1.Balfour, HH Jr: Acyclovir and other chemotherapy for herpes group viral infections. Annu Rev Med 1984;35:279–291.CrossRefGoogle ScholarPubMed
2.Gnann, JW, Barton, NH, Whitley, RJ: Acyclovir: Mechanism of action, pharmacokinetics, safety, and clinical applications. Pharmacotherapy 1983;3:275–283.CrossRefGoogle ScholarPubMed
3.Elion, GB: Mechanism of action and selectivity of acyclovir. Am J Med 1982;73(suppl 1A):7–13.Google Scholar
4.Rosenberry, KR, Bryan, CK, Sohn, CA: Acyclovir: Evaluation of a new antiviral agent. Clin Pharm 1982;1:399–406.Google ScholarPubMed
5.Meguirt, PV, Furman, PA: Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus infected cells. Am J Med 1982;73(suppl 1A):67–71.Google Scholar
6.Hopefl, AW: The clinical use for intravenous acyclovir. Drug Intell Clin Pharm 1983;17:623–628.Google Scholar
7.Brigden, D, Kenney, RE, King, DH: The present and future for acyclovir. J Antimicrob Chemother 1983;12:195–199.Google Scholar
8.Laskin, OL: Clinical pharmacokinetics of acyclovir. Clin Pharmacokinet 1983;8:187–201.Google Scholar
9.de Miranda, P, Blum, MR: Pharmacokinetics of acyclovir after intravenous and oral administration. J Antimicrob Chemother 1983;12:29–36.Google Scholar