Hostname: page-component-7b7567c8c-kwt9d Total loading time: 0 Render date: 2026-11-15T01:18:31.231Z Has data issue: false hasContentIssue false
  • English
  • Français

Nafcillin Resistant Staphylococcus Aureus A Possible Community Origin

Published online by Cambridge University Press:  02 January 2015

Ayser C. Hamoudi,
Robert N. Palmer and
Timothy L King
Ayser C. Hamoudi*
Affiliation:
Departments of Laboratory Medicine and Epidemiology, Children's Hospital, Columbus Ohio
Robert N. Palmer
Affiliation:
Departments of Laboratory Medicine and Epidemiology, Children's Hospital, Columbus Ohio
Timothy L King
Affiliation:
Departments of Laboratory Medicine and Epidemiology, Children's Hospital, Columbus Ohio
*
Children's Hospital, 700 Children's Drive, Columbus, OH 43205
Get accessRights & Permissions [Opens in a new window]

Abstract

An increased incidence in nafcillin (semisynthetic penicillins) resistant Staphylococcus aureus (SR-SA), which peaked in January 1980, was noted in Columbus Children's Hospital (CCH), Columbus, Ohio. To investigate the source of this outbreak, we reviewed the susceptibility patterns of S. aureus strains isolated at CCH for a 12-month period (July 1979 to June 1980). A total of 773 isolates from 706 patients were investigated with a total of 40 patients colonized or infected with SR-SA, approximately 25% of which were diagnosed in the ambulatory clinics. These patients did not have any apparent previous contact with the inpatient unit or inpatient personnel. Eight nosocomial infections were also uncovered. The first appeared in December 1979. Our studies suggested that some SR-SA isolates may have originated in the community and these organisms may not be exclusive to the hospital environment, as was felt to be the case previously. We also determined that the baseline incidence for our hospital of SR-SA was approximately 2% of total S. aureus isolates. Only 35% of the SR-SA demonstrated resistance to multiple antibiotics. This report indicates that community and nosocomial 5. aureus isolates should be monitored for nafcillin resistance. Vancomycin susceptibility should be tested on all isolates and reported for SR-SA in life-threatening infections.

Information

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 4 , Issue 3 , May/June 1983, pp. 153 - 157
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1.National nosocomial infections study report, annual summary, 1974. Atlanta, Center for Disease Control, March 1977.Google Scholar
2.Meakins, JL, Wieklund, B, Forse, RA, et al: The surgical intensive care unit: Current concepts in infection. Surg Clin North Am 1980; 60:117–132.CrossRefGoogle ScholarPubMed
3.Barret, FF, McGehee, RF Jr, Finland, M: Methicillin-resistant Staphylococcus aureus at Boston City Hospital: Bacteriologic and epidemiologic observations. N Engl'J Med 1968; 279:441–448.CrossRefGoogle Scholar
4.O'Toole, RD, Drew, L, Dahlgren, BJ, et al: An outbreak of methicillin-resistant Staphylococcus aureus infection: Observations in hospital and nursing home. JAMA 1970; 213:257–263.CrossRefGoogle ScholarPubMed
5.Klimek, JJ, Marsik, FJ, Bartlett, RC, et al: Clinical, epidemiologic and bacteriologie observations of an outbreak of methicillin-resistant Staphylococcus aureus at a large community hospital. Am J Med 1976; 61:340–345.CrossRefGoogle Scholar
6.Crossley, K, Loesch, D, Landesman, B, et al: An outbreak of infections caused by strains of Staphylococcus aureus resistant to methicillin and aminoglycosides. J Infect Dis 1979; 139:273–287.CrossRefGoogle ScholarPubMed
7.Peacock, JE Jr., Marsik, FJ, Wenzel, RP: Methicillin-resistant Staphyococcus aureus: Introduction and spread within a hospital. Ann Intern Med 1980; 93:526–532.CrossRefGoogle Scholar
8.Boyce, JM, Landry, M, Deetz, TR, et al: Epidemiological studies of an outbreak of nosocomial methicillin-resistant Staphylococcus aureus infections. Infect Control 1981; 2:110–116.CrossRefGoogle ScholarPubMed
9.Thompson, RL, Cabezudo, I, Wenzel, RP: Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. Ann Intern Med 1982; 97:309–317.CrossRefGoogle ScholarPubMed
10.Cetin, ET, Ang, O: Staphylococci resistant to methicillin (“celbenin”). Br Med J 1962; 2:52.CrossRefGoogle Scholar
11.Parker, MT, Jevons, MP: A survey of methicillin-resistance in Staphylococcus aureus. Postgrad Med J 1964; 40(suppl): 170–178.CrossRefGoogle ScholarPubMed
12.Erkinsen, KR, Erichsen, I: Resistance to methicillin, isoxazolyl penicillins and cephalothin in Staphylococcus aureus. Acta Pathol Microbiol Scand 1964; 62:255–275.Google Scholar
13.Benner, EJ, Kayser, FH: Growing clinical significance of methicillin-resistant Staphylococcus aureus. Lancet 1968; 2:741–744.CrossRefGoogle Scholar
14.Wenzel, RP, Donowitz, L, Miller, GB Jr: Methicillin-resistant Staphylococcus aureus— United States. MMWR 1981; 30:140.Google ScholarPubMed
15.Saravolatz, LD, Pholod, DJ, Arking, LM: Community-acquired methicillin-resistant Staphylococcus aureus infections: A new source for nosocomial outbreaks. Ann Intern Med 1982; 97:325–329.CrossRefGoogle ScholarPubMed
16.Outline for surveillance and control of nosocomial injection. US Dept. of Health, Education, and Welfare (PHS). Atlanta, Centers for Disease Control, 1976, pp 1–16.Google Scholar
17.NCCLS Approved Standards: ASM-Performance-Standards for Antimicrobic Disc Susceptibility Tests, ed 2. National Committee for Clinical Laboratory Standards. October 1979.Google Scholar
18.Ward, TT, Winn, RE, Hartstein, AI, et al: Observations relating to an interhospital outbreak of methicillin-resistant S. aureus: Role of antimicrobial therapy in infection control. Infect Control 1981; 2(6):453–459.CrossRefGoogle Scholar
19.Schaefler, S, Perry, JW, Ruvinskaya, L, et al: Emergence of gentamicin and methicillin-resistant Staphylococcus aureus strains in New York City hospitals. J Clin Microbiol 1981; 13:754–759.CrossRefGoogle ScholarPubMed
20.Everett, ED, Rahm, AE, McNitt, TR, et al: Epidemiologic investigation of methicillin-resistant Staphylococcus aureus in a burn unit. Milit Med 1978; 143:165–167.CrossRefGoogle Scholar
21.Cushing, R, Jui, J, Levine, DP, et al: Community-acquired methicillin-resistant Staphylococcus aureus infections—Michigan. MMWR 1981; 30:185–187.Google Scholar
22.Bennet, JV, Brachman, PS: Hospital infections. Boston, Little Brown & Co., 1979; p 197.Google Scholar