White matter microstructural abnormalities in late-life depression

Qiong Yang; Xuebing Huang; Nan Hong; Xin Yu

doi:10.1017/S1041610207004875

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

Objective: To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI).

Methods: Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum.

Results: FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls.

Conclusion: Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Yuan, Yonggui Zhang, Zhijun Bai, Feng Yu, Hui Shi, Yongmei Qian, Yun Zang, Yufeng Zhu, Caozhe Liu, Wen and You, Jiayong 2007. White matter integrity of the whole brain is disrupted in first-episode remitted geriatric depression. NeuroReport, Vol. 18, Issue. 17, p. 1845.

Taylor, Warren D. Kuchibhatla, Maragatha Payne, Martha E. MacFall, James R. Sheline, Yvette I. Krishnan, K. Ranga Doraiswamy, P. Murali and García, Antonio Verdejo 2008. Frontal White Matter Anisotropy and Antidepressant Remission in Late-Life Depression. PLoS ONE, Vol. 3, Issue. 9, p. e3267.

Thomas, P. and Hazif-Thomas, C. 2008. Particularités médicosociales de la dépression du sujet âgé : le point en 2008. NPG Neurologie - Psychiatrie - Gériatrie, Vol. 8, Issue. 48, p. 27.

2008. Current World Literature. Current Opinion in Psychiatry, Vol. 21, Issue. 6, p. 651.

2008. Current awareness in geriatric psychiatry. International Journal of Geriatric Psychiatry, Vol. 23, Issue. 4,

Pfefferbaum, Adolf and Sullivan, Edith V. 2009. Clinical MR Neuroimaging. p. 593.

Shimony, Joshua S. Sheline, Yvette I. D'Angelo, Gina Epstein, Adrian A. Benzinger, Tammie L.S. Mintun, Mark A. McKinstry, Robert C. and Snyder, Abraham Z. 2009. Diffuse Microstructural Abnormalities of Normal-Appearing White Matter in Late Life Depression: A Diffusion Tensor Imaging Study. Biological Psychiatry, Vol. 66, Issue. 3, p. 245.

Koolschijn, P. Cédric M.P. van Haren, Neeltje E.M. Lensvelt‐Mulders, Gerty J.L.M. Hulshoff Pol, Hilleke E. and Kahn, René S. 2009. Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies. Human Brain Mapping, Vol. 30, Issue. 11, p. 3719.

Chiu, Edmond Ames, David Draper, Brian and Snowdon, John 2009. Depressive Disorders. p. 197.

Sexton, Claire E. Mackay, Clare E. and Ebmeier, Klaus P. 2009. A Systematic Review of Diffusion Tensor Imaging Studies in Affective Disorders. Biological Psychiatry, Vol. 66, Issue. 9, p. 814.

Hwang, Jen-Ping Lee, Tien-Wen Tsai, Shi-Jen Chen, Tai-Jui Yang, Chen-Hong Lirng, Jiing-Feng and Tsai, Chia-Fen 2010. Cortical and Subcortical Abnormalities in Late-Onset Depression With History of Suicide Attempts Investigated With MRI and Voxel-Based Morphometry. Journal of Geriatric Psychiatry and Neurology, Vol. 23, Issue. 3, p. 171.

Williamson, John Nyenhuis, David Stebbins, Glenn T. Lamb, Damon Simkus, Vaidas Sripathirathan, Kumar Wang, Changsheng deToledo-Morrell, Leyla and Gorelick, Philip 2010. Regional differences in relationships between apparent white matter integrity, cognition and mood in patients with ischemic stroke. Journal of Clinical and Experimental Neuropsychology, Vol. 32, Issue. 7, p. 673.

Kumar, Anand and Ajilore, Olusola 2010. Understanding Neuropsychiatric Disorders. p. 139.

Maller, Jerome J. Thomson, Richard H.S. Lewis, Philip M. Rose, Stephen E. Pannek, Kerstin and Fitzgerald, Paul B. 2010. Traumatic brain injury, major depression, and diffusion tensor imaging: Making connections. Brain Research Reviews, Vol. 64, Issue. 1, p. 213.

Versace, Amelia Almeida, Jorge R.C. Quevedo, Karina Thompson, Wesley K. Terwilliger, Robert A. Hassel, Stefanie Kupfer, David J. and Phillips, Mary L. 2010. Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression. Biological Psychiatry, Vol. 68, Issue. 6, p. 560.

Kieseppä, Tuula Eerola, Mervi Mäntylä, Riitta Neuvonen, Tuomas Poutanen, Veli-Pekka Luoma, Katariina Tuulio-Henriksson, Annamari Jylhä, Pekka Mantere, Outi Melartin, Tarja Rytsälä, Heikki Vuorilehto, Maria and Isometsä, Erkki 2010. Major depressive disorder and white matter abnormalities: A diffusion tensor imaging study with tract-based spatial statistics. Journal of Affective Disorders, Vol. 120, Issue. 1-3, p. 240.

Dalby, Rikke Beese Frandsen, Jesper Chakravarty, M. Mallar Ahdidan, Jamila Sørensen, Leif Rosenberg, Raben Videbech, Poul and Østergaard, Leif 2010. Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression. Psychiatry Research: Neuroimaging, Vol. 184, Issue. 1, p. 38.

Taylor, Warren D. MacFall, James R. Boyd, Brian Payne, Martha E. Sheline, Yvette I. Krishnan, Ranga R. and Murali Doraiswamy, P. 2011. One-Year Change in Anterior Cingulate Cortex White Matter Microstructure: Relationship With Late-Life Depression Outcomes. The American Journal of Geriatric Psychiatry, Vol. 19, Issue. 1, p. 43.

Wu, Feng Tang, Yanqing Xu, Ke Kong, Lingtao Sun, Wenge Wang, Fei Kong, Dongyan Li, Yanliang and Liu, Ying 2011. Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder. Psychiatry Research: Neuroimaging, Vol. 191, Issue. 1, p. 80.

Korgaonkar, Mayuresh S. Grieve, Stuart M. Koslow, Stephen H. Gabrieli, John D.E. Gordon, Evian and Williams, Leanne M. 2011. Loss of white matter integrity in major depressive disorder: Evidence using tract‐based spatial statistical analysis of diffusion tensor imaging. Human Brain Mapping, Vol. 32, Issue. 12, p. 2161.

Download full list

Article contents

White matter microstructural abnormalities in late-life depression

Abstract

Keywords

Information

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Article contents

White matter microstructural abnormalities in late-life depression

Abstract

Keywords

Information

Save article to Kindle

Save article to Dropbox

Save article to Google Drive

Reply to: Submit a response

Your details

You have entered the maximum number of contributors

Conflicting interests