Hostname: page-component-7b7567c8c-2n9c9 Total loading time: 0 Render date: 2026-11-15T14:41:29.686Z Has data issue: false hasContentIssue false
  • English
  • Français

The ovary learns to ovulate

Published online by Cambridge University Press:  27 September 2011

B. Lunenfeld,
Z. Kraiem,
A. Eshkol and
I. Werner-Zodrow
B. Lunenfeld
Affiliation:
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel and the Department of Social Medicine,University Hospital for Women, Basle, Switzerland
Z. Kraiem
Affiliation:
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel and the Department of Social Medicine,University Hospital for Women, Basle, Switzerland
A. Eshkol
Affiliation:
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel and the Department of Social Medicine,University Hospital for Women, Basle, Switzerland
I. Werner-Zodrow
Affiliation:
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel and the Department of Social Medicine,University Hospital for Women, Basle, Switzerland
Get accessRights & Permissions [Opens in a new window]

Extract

Sensory stimuli from the external environment (e.g. visual and olfactory stimuli, stress) or internal stimuli cause brain nerve fibres to release neurotransmitters (catecholamines, indolamines and cholinergic agents). These neurotransmitters regulate the secretion of gonadotrophin-releasing hormone (GnRH) from neurosecretory cells of the hypothalamus (Kamberi, 1975). It would seem that under the proper steroid environment, catecholamines (dopamine, norepinephrine or epinephrine) and the cholinergic agent acetylcholine exert a stimulatory influence, whereas indolamines (serotonin or its metabolic product, melatonin) have an opposite effect. In turn, GnRH reaches the anterior pituitary via the hypophyseal portal system, and, through the mediation of cAMP [though may be not as an obligatory intermediate (Naor et al., 1975)], controls gonadotrophin secretion (Labrie et al., 1974).

Information

Type
I. Genital maturation
Information
Journal of Biosocial Science , Volume 10 , supplement S5: Fertility in Adolescence , 1978, pp. 27 - 42
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Abraham, G.E., Odell, W.D., Swerdloff, R.S. & Hopper, K. (1972) Simultaneous radioimmunossay of plasma FSH, LH, progesterone, 17-hydroxyprogesterone and estradiol-17β during the menstrual cycle. J. clin. Endocr. Metab. 34, 312.Google Scholar
Aedo, A.R., Landgren, B.M., Cekan, Z. & Diczfalusy, E. (1976) Studies on the pattern of circulating steroids in the normal menstrual cycle. Acta endocr., Copenh. 82, 600.Google Scholar
Armstrong, D.T., Kraemer, M.A. & Hixon, J.E. (1975) Metabolism of progesterone by rat ovarian tissue: influence of pregnant mare serum gonadotrophin and prolactin. Biol. Reprod. 12, 599.Google Scholar
Armstrong, D.T. & Papkoff, H. (1976) Stimulation of aromatization of exogenous and endogenous androgens in ovaries of hypophysectomized rats in vivo by follicle-stimulating hormone. Endocrinology, 99, 1144.Google Scholar
Barraclough, C.A. (1973) Sex steroid regulation of reproductive neuroendocrine processes. In: Handbook of Physiology, Vol. II, Female Reproductive System, p. 29. American Physiological Society, Washington.Google Scholar
Bauminger, S. & Lindner, H.R. (1975) Periovulatory changes in ovarian prostaglandin formation and their hormonal control. Prostaglandins, 9, 737.Google Scholar
Bayard, F., Damilano, S., Robel, P. & Baulieu, E.E. (1975) Recepteurs de l'oestradiol et de la progesterone dans l'endometre humain au cours du cycle menstruel. C.r. Acad. Sci. Paris, 281D, 1341.Google Scholar
Becker, H., Klupp, M., Epstein, Y., Seidl, U. & Lunenfeld, B. (1977) Evidence for an FSH-inhibitory factor derived from follicular fluid. Abstracts of the 59th Annual Meeting of the Endocrine Society, p. 246, The Endocrine Society, Chicago.Google Scholar
Beers, W.H., Strickland, S. & Reich, E. (1975) Ovarian plasminogen activator: relationship to ovulation and hormonal regulation. Cell, 6, 387.CrossRefGoogle ScholarPubMed
Channing, C.P. & Kammerman, S. (1974) Binding of gonadotrophins to ovarian cells. Biol. Reprod. 10, 179.Google Scholar
Channing, C.P. & Tsafriri, A. (1977a) Regulation of ovulatory processes: ovum maturation, follicular rupture and luteinization. In: Advances in Fertility Regulation Through Basic Research. Edited by Sadler, W. A. & Segal, S.. Plenum Press, New York.Google Scholar
Channing, C.P. & Tsafriri, A. (1977b) Mechanism of action of luteinizing hormone and folliclestimulating hormone on the ovary in vitro. Metabolism, 26, 413.Google Scholar
Eckstein, B. & Lerner, N. (1978) Changes in ovarian 5α-steroid reductase and 20α-hydroxysteroid dehydrogenase activity produced by induction of first ovulation with gonadotrophin. Biochimica et Biochimica Acta, Lipid Section, In press.Google Scholar
Eckstein, B. & Ravid, R. (1974) On the mechanism of the onset of puberty: identification and pattern of 5α-androstane-3β, 17β-diol and its 3α-epimer in peripheral blood of immature rats. Endocrinology, 94, 224.CrossRefGoogle Scholar
Eshkol, A. & Lunenfeld, B. (1976) Control of follicular development: induction of FSH and LH receptors. Excerpta med. Int. Congr. Ser. No. 402, 318.Google Scholar
Guerrero, R., Aso, T., Brenner, P.F., Cekan, Z., Landgren, B.M., Hagenfeldt, K. & Diczfalusy, E. (1976) Studies on the pattern of circulating steroids in the normal menstrual cycle. Acta endocr., Copenh. 81, 133.Google Scholar
Hyppä, M.T. (1974) Neuroendocrine control of puberty: role of perinatal neuroamines. In: International Symposium on Sexual Endocrinology of the Perinatal Period, p. 395. INSERM, Lyon.Google Scholar
Job, J.C. (1973) Influence of endocrine equilibrium on the response to LH-RH in normal children. In: Some Aspects of Hypothalamic Regulation of Endocrine Functions. Symposia Medica Hoechst, 7, 121. Schattauer-Verlag, Stuttgart.Google Scholar
Jungmann, R.A., Hiestand, C.P. & Schweppe, J.S. (1974) Mechanism of action of gonadotrophin. Endocrinology, 94, 168.Google Scholar
Kamberi, I.A. (1975) Brain neurotransmitters and their interaction with the hypothalamic-pituitary-gonadal principles. In: Advances in the Biosciences 15, Schering Workshop on Central Actions of Estrogenic Hormones, p. 249. Pergamon Press, Oxford.Google Scholar
Kraiem, Z. & Lunenfeld, B. (1976) cAMP accumulation inhibitor in follicular fluid of human origin. Abstracts of the 58th Annual Meeting of the Endocrine Society, p. 141, The Endocrine Society, San Francisco.Google Scholar
Kuhl, H. & Taubert, H.D. (1975) Inactivation of luteinizing hormone releasing hormone by rat hypothalamic L-cystine arylamidase. Acta endocr., Copenh. 78, 649.Google ScholarPubMed
Kulin, H.E., Grumbach, M.M. & Kaplan, S.L. (1972) Gonadal-hypothalamic interaction in prepubertal and pubertal man: effect of clomiphene citrate on urinary FSH and LH and plasma testosterone. Pediat. Res. 6, 162.Google Scholar
Labrie, F., Pelletier, G., Borgeat, P., Drouin, J., Savary, M., Cote, J. & Ferland, L. (1974) Mechanism of action of luteinizing hormone-releasing hormone. In: Physiology and Genetics of Reproduction, part A, p. 289. Edited by Coutinho, E. M. & Fuchs, F.. Plenum Press, New York.CrossRefGoogle Scholar
Ledwitz-Rigby, F., Rigby, B.W., Gay, V.L., Stetson, M., Young, J. & Channing, C.P. (1977) Inhibitory action of porcine follicular fluid upon granulosa cell luteinization in vitro: assay and influence of follicular maturation. J. Endocr. 74, 175.CrossRefGoogle Scholar
Leleux, P. & Robyn, C. (1971) Immunohistochemistry of individual adenohypophyseal cells. In: Karolinska Symposia on Research Methods in Reproductive Endocrinology, 3rd Symp. 3, 168. Edited by Diczfalusy, E.. Bogytrykkeriet Forum, Copenhagen.Google Scholar
Le Maire, W.J., Leidner, R. & Marsh, J.M. (1975) Pre- and post-ovulatory changes in the concentrations of prostaglandins in rat graafian follicles. Prostaglandins, 9, 221.Google Scholar
Lindner, H.R., Amsterdam, A., Salomon, Y., Tsafriri, A., Nimrod, A., Lamprecht, S.A., Zor, U. & Koch, Y. (1977) Intraovarian factors in ovulation: determinants of follicular response to gonadotrophins. J. Reprod. Fert. 51, 215.CrossRefGoogle Scholar
Louvet, J.P., Harman, S.M., Schreiber, J.R. & Ross, G.T. (1975) Evidence for a role of androgens in follicular maturation. Endocrinology, 97, 366.Google Scholar
Lunenfeld, B., Ben-Aderet, N., Ben-Michael, R., Grünstein, S., Kraiem, Z., Potashnik, G., Rofe, C., Shalit, A. & Tikotsky, D. (1977) Correlation of hormonal profile and ovarian morphological features during the periovulatory period in humans. Revue fr. Endocr. clin. 17, 420.Google Scholar
Lunenfeld, B. & Eshkol, A. (1977) Therapeutically oriented classification of anovulation of neuroendocrine or endocrine origin. In: Human Ovulation. Edited by Hafez, E. S. E.. Elsevier/North-Holland, Amsterdam.Google Scholar
Lunenfeld, B., Insler, V., Eshkol, A. & Birenboim, N. (1974) Pituitary responsiveness to gonadotrophin releasing hormones. Horm. Metab. Res. 5, 184.Google Scholar
Marsh, J.M. (1976) The role of cyclic AMP in gonadal steroidogenesis. Biol. Reprod. 14, 30.CrossRefGoogle ScholarPubMed
Mcnatty, K.P., Mcneilly, A.S. & Sawers, R.S. (1977) Prolactin and progesterone secretion by human granulosa cells in vitro. In: Prolactin and Human Reproduction, p. 109. Edited by Crosignani, P. G. & Robyn, C.. Academic Press, New York.Google Scholar
Nakane, P.K. (1973) Distribution of gonadotrophic cells in the anterior pituitary gland of the rat. In: The Regulation of Mammalian Reproduction. Thomas, Springfield.Google Scholar
Naor, Z., Koch, Y., Chobsieng, P. & Zor, U. (1975) Pituitary cyclic AMP production and mechanism of luteinizing hormone release. FEBS, 58, 318.Google Scholar
Phifer, R.F., Midgley, A.R. & Spicer, S.S. (1973) Immunohistologic and histologic evidence that follicle-stimulating hormone and luteinizing hormone are present in the same cell type in the human pars distalis J. clin. Endocr. Metab. 36, 125.Google Scholar
Richards, J.S. & Midgley, A.R. (1976) Protein hormone action: a key to understanding ovarian follicular and luteal cell development. Biol. Reprod. 14, 82.Google Scholar
Rondell, P. (1974) Role of steroid synthesis in the process of ovulation. Biol. Reprod. 10, 199.CrossRefGoogle ScholarPubMed
Ross, G.T., Cargille, C.M., Lipsett, M.B., Rayford, P.L., Marshall, J.R., Strott, C.A. & Rodbard, D. (1970) Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles. Rec. Prog. Horm. Res. 26, 1.Google ScholarPubMed
Ruf, K.B. (1973) How does the brain control the process of puberty? Z. Neural. 204, 95.Google Scholar
Schwarzel, W.C., Kruggel, W.G. & Brodie, H.J. (1973) Studies on the mechanism of estrogen biosynthesis. VII. The development of inhibitors of the enzyme system in human placenta. Endocrinology, 92, 866.CrossRefGoogle Scholar
Short, R.V. (1974) Rhythms of ovulation. In: Chronobiological Aspects of Endocrinology. Symposia Medica Hoechst, 9, p. 221. Schattauer-Verlag, Stuttgart.Google Scholar
Speroff, L. & Van de Wiele, R.B. (1971) Regulation of the human menstrual cycle. Am. J. Obstet. Gynec. 109, 234.Google Scholar
Steele, R.E. (1977) Role of the ovaries in maturation of the estradiol-luteinizing hormone negative feedback system of the pubertal rat. Endocrinology, 101, 587.Google Scholar
Swerdloff, R.S., Jacors, H.S. & Odell, W.P. (1972) Synergistic role of progesterone in estrogen induction of LH and FSH surge. Endocrinology, 90, 1529.Google Scholar
Tsafriri, A., Lieberman, M.E., Barnea, A., Bauminger, S. & Lindner, H.R. (1973) Induction by luteinizing hormone of ovum maturation and of steroidogenesis in isolated graafian follicles of the rat: role of RNA and protein synthesis. Endocrinology, 93, 1378.Google Scholar
Tsafriri, A., Pomerantz, S.H. & Channing, C.P. (1976) Inhibition of oocyte maturation by porcine follicular fluid: partial characterization of the inhibitor. Biol. Reprod. 14, 511.Google Scholar
Van de Wiele, R.L., Bogumil, J., Dyrenfurth, I., Ferin, M., Jewelewicz, R., Warren, M., Rizkallah, T. & Mikhail, G. (1970) Mechanisms regulating the menstrual cycle in women. Rec. Prog. Horm. Res. 26, 63.Google Scholar
WHO (1977) Health needs of adolescence. Tech. Rep. Ser. Wld Hlth Org. 609.Google Scholar
Yen, S.S.C. (1977) Regulation of the hypothalamic–pituitary–ovarian axis in women. J. Reprod. Fert. 51, 181.CrossRefGoogle ScholarPubMed
Younglai, E. V. (1975) Steroid production by the isolated rabbit ovarian follicle. III. Actinomycin D-insensitive stimulation of steroidogenesis by LH. Endocrinology, 96, 468.Google Scholar