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Functional glucosamine-iron oxide nanocarriers

Published online by Cambridge University Press:  11 June 2020

Luis M. R. Rivera,
Julhyana G. Machado,
Mohan Chandra Mathpal,
Natalia L. Chaves,
Danijela Gregurec,
Sônia N. Báo,
Leonardo G. Paterno,
Sergio E. Moya,
Ricardo B. Azevedo and
Maria A. G. SolerOpen the ORCID record for Maria A. G. Soler[Opens in a new window]
Luis M. R. Rivera
Affiliation:
Instituto de Física, Universidade de Brasilia, Brasilia, DF70910-900, BrazilInstituto de Ciências Biológicas, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Julhyana G. Machado
Affiliation:
Instituto de Física, Universidade de Brasilia, Brasilia, DF70910-900, BrazilInstituto de Ciências Biológicas, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Mohan Chandra Mathpal
Affiliation:
Instituto de Física, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Natalia L. Chaves
Affiliation:
Instituto de Ciências Biológicas, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Danijela Gregurec
Affiliation:
Soft Matter Nanotechnology Laboratory, CIC biomaGUNE, Guipuzkoa20009, Spain
Sônia N. Báo
Affiliation:
Instituto de Ciências Biológicas, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Leonardo G. Paterno
Affiliation:
Instituto de Química, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Sergio E. Moya
Affiliation:
Soft Matter Nanotechnology Laboratory, CIC biomaGUNE, Guipuzkoa20009, Spain
Ricardo B. Azevedo
Affiliation:
Instituto de Ciências Biológicas, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
Maria A. G. Soler*
Affiliation:
Instituto de Física, Universidade de Brasilia, Brasilia, DF70910-900, Brazil
*
a)Address all correspondence to this author. e-mail: soler@unb.br
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Abstract

Herein, we report a synthetic route capable of producing superparamagnetic, stable and biocompatible glucosamine (GLU) nanocarriers, composed by colloidal iron oxide nanoparticles (ION, ~6 nm) surface-functionalized with GLU dispersed in physiological media (pH 7.2). The route consists first of the preparation of ION by aqueous alkaline co-precipitation of 1:2 Fe(II)/Fe(III) followed by surface treatment with citric acid, activation of acidic groups via carbodiimide intermediary and further amidation using GLU as the amine reactant. Results from cell viability tests performed with human dental pulp tissue cells suggest that ION–GLU nanocolloids are biocompatible and non-toxic for two different concentrations and several hours of incubation. Moreover, optical microscopy shows that ION–GLU adsorbs at the cells walls and also transposes them, reaching cytoplasm and nucleus as well. All findings point out the promising use of ION–GLU as biocompatible nanocarriers for GLU delivery such as in articulation diseases.

Keywords

biomaterialsmagneticnanostructureglucosaminefunctional nanomaterialiron oxide nanoparticle

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Article
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Journal of Materials Research , Volume 35 , Issue 13: Focus Section: Interactions of Shear Transformation Bands , 14 July 2020, pp. 1726 - 1737
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Copyright © Materials Research Society 2020

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