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A multifunctional poly(acrylic acid)/gelatin hydrogel

Published online by Cambridge University Press:  31 January 2011

Qunwei Tang,
Jihuai Wu,
Jianming Lin,
Shijun Fan and
De Hu
Jihuai Wu*
Affiliation:
The Key Laboratory for Functional Materials of Fujian Higher Education Institute of Materials Physical Chemistry, Huaqiao University, Quanzhou, 362021, China
De Hu
Affiliation:
The Key Laboratory for Functional Materials of Fujian Higher Education Institute of Materials Physical Chemistry, Huaqiao University, Quanzhou, 362021, China
*
a) Address all correspondence to this author. e-mail: jhwu@hqu.edu.cn
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Abstract

A poly(acrylic acid)/gelatin interpenetrating network hydrogel was synthesized by aqueous solution polymerization. The influences of preparation conditions including cross-linker, initiator, gelatin content, and neutralization degree on the swelling ratios of the hydrogels are investigated. The swelling, mechanical strength, biodegradability, and drug-release properties of poly(acrylic acid)/gelatin hydrogel are evaluated. The hydrogel has excellent mechanical properties; tensile strength is 1500 kPa, and elongation at break is 887%, respectively. The in vitro biodegradation shows that an interpenetrating network structure exists in the poly(acrylic acid)/gelatin hybrid hydrogel. A release study indicates that the theophylline release from the hydrogel depends on the cross-linking density of the hydrogel and pH of the medium, and the drug diffusion obeys an anomalous transport model.

Keywords

AdsorptionBiomaterialPolymerization

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Type
Articles
Information
Journal of Materials Research , Volume 24 , Issue 5 , May 2009, pp. 1653 - 1661
Copyright
Copyright © Materials Research Society 2009

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