Prof. Golla, in introducing the discussion, said: I do not think there is any subject that is of greater importance at the present moment than the physiology and the pathology of the circulation of the central nervous system. I am dealing now with the physiology, with a view to putting a few facts before you which are fairly well authenticated, and pointing out how very little we know at present. I do not intend to speak of the pathological aspect, but I may remind you, in passing, of such things as the therapeutic effects of amytal and of CO2. Again, in the case of epilepsy, whatever one's ultimate view of epilepsy is, we are all agreed that circulatory disturbance plays a very large part.