This paper identifies and considers difficulties that gave rise to successful appeals from prosecutions where expert evidence was relied upon to demonstrate that defendants had killed or caused harm to infants in their care. It evaluates the extent to which these difficulties may be addressed by measures which have been introduced or proposed by way of tackling problems associated with expert evidence. Part of the paper is dedicated to an analysis of the Law Commission's consultation paper on the admissibility of expert evidence in criminal proceedings. The paper argues that trial judges may not be best placed to discharge the Law Commission's proposed gate-keeping test for screening the reliability of expert evidence. Expert evidence will often be ‘outcome determinative’ in prosecutions for infant harm, which is why we argue for the introduction of a specialist gate-keeping panel instead to determine the reliability of new theories and techniques.